MIRLET7I (microRNA let-7i)

Gene Basic Information

Gene Basic Information

symbol:
MIRLET7I
locus group:
non-coding RNA
location:
12q14.1
gene_family:
MicroRNAs
alias symbol:
hsa-let-7i
alias name:
None
entrez id:
406891
ensembl gene id:
ENSG00000199179
ucsc gene id:
uc001srj.3
refseq accession:
NR_029661
hgnc_id:
HGNC:31486
approved reserved:
2004-04-23

Chromosome Location

Chromosome Location

12q14.1

Gene Summary

Gene Summary

ChineseEnglish

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM entry for MIRLET7I     Wikipedia entry for MIRLET7I

Gene Sequence

Gene Sequence

Nucleotide sequence of MIRLET7I:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of MIRLET7I:           Showing partial SNPs
rs7302456       rs10877885       rs10877886       rs10877887       rs35646256       rs67218157       rs73325235       rs79508661       rs113188524       rs113451066       rs113453964       rs116016365       rs117892642       rs118013734       rs118126121       rs139089485       rs139119750      

Gene Expression

Gene Expression

Tissue expression of MIRLET7I:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TAGTTTGTGCTGTTGGTCG
58
GTAGCTTGCGCAGTTATCTC
59
GTAGTAGTTTGTGCTGTTGGTC
60
CTTGCGCAGTTATCTCCAC
59
GTAGTAGTTTGTGCTGTTGGT
59
CTTGCGCAGTTATCTCCAC
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MIRLET7I (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MIRLET7I:

Related microRNA

Related microRNA

microRNAs potentially regulating MIRLET7I:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Liver Neoplasms, Experimental 0.12 1 0 CTD_human
Cholestasis 0.12 1 0 CTD_human
Myocardial Reperfusion Injury 0.12 1 0 CTD_human

Related Publications

Related Publications

Circulating T cell-specific extracellular vesicles as biomarkers of acute cellular rejection after lung transplantation.
Korutla L, Mineura K, DeMarais N, Liu CR, Burke V, Bai YZ, Habertheuer A, Hameed I, Terada Y, Talapaneni S, Kawana S, Shepherd H, Ritter JH, Kreisel D, Vallabhajosyula P Am J Transplant IF: 8.1 2026-09-00

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