MOXD1 (monooxygenase DBH like 1)

Gene Basic Information

Gene Basic Information

symbol
MOXD1
locus group
protein-coding gene
location
6q23.2
gene_family
-
alias symbol
DKFZP564G202|MOX|dJ248E1.1
alias name
None
entrez id
26002
ensembl gene id
ENSG00000079931
ucsc gene id
uc003qdf.4
refseq accession
NM_015529
hgnc_id
HGNC:21063
approved reserved
2003-06-20

Chromosome Location

Chromosome Location

6q23.2

Gene Summary

Gene Summary

MOXD1（Monooxygenase DBH-like 1）是一种属于铜离子依赖性单加氧酶家族的基因，与多巴胺β-羟化酶（DBH）基因家族密切相关。该家族成员通常参与儿茶酚胺类神经递质（如多巴胺、去甲肾上腺素）的合成或代谢过程，其共性在于依赖铜离子和抗坏血酸作为辅因子催化底物的羟基化反应。MOXD1主要在肝脏、肾脏和大脑中表达，其编码的蛋白质可能参与脂质代谢或神经活性物质的修饰，但具体生物学功能尚未完全阐明。研究表明，MOXD1可能通过影响神经递质平衡或类固醇代谢参与血压调节，其表达异常可能与心血管疾病或神经系统紊乱相关。当MOXD1发生突变时，可能导致酶活性丧失或降低，进而干扰其参与的代谢通路，但具体病理机制仍需进一步研究。过表达MOXD1可能通过改变特定代谢产物水平影响细胞信号传导，而表达降低则可能导致某些内源性物质积累或缺乏。值得注意的是，MOXD1与DBH具有相似的结构域，但底物特异性可能存在差异。目前关于该基因的研究相对有限，其精确的生理作用、调控网络及疾病关联仍需更多实验证据支持。

OMIM entry for MOXD1     Wikipedia entry for MOXD1

Gene Sequence

Gene Sequence

Nucleotide sequence of MOXD1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MCCWPLLLLW GLLPGTAAGG SGRTYPHRTL LDSEGKYWLG
41WSQRGSQIAF RLQVRTAGYV GFGFSPTGAM ASADIVVGGV
81 AHGRPYLQD YFTNANRELK KDAQQDYHLE YAMENSTHTI
121IEFTRELHTC DINDKSITDS TVRVIWAYHH EDAGEAGPKY
161H DSNRGTKS LRLLNPEKTS VLSTALPYFD LVNQDVPIPN
201KDTTYWCQMF KIPVFQEKHH VIKVEPVIQR GHESLVHHIL
241LY QCSNNFN DSVLESGHEC YHPNMPDAFL TCETVIFAWA
281IGGEGFSYPP HVGLSLGTPL DPHYVLLEVH YDNPTYEEGL
321IDN SGLRLF YTMDIRKYDA GVIEAGLWVS LFHTIPPGMP
361EFQSEGHCTL ECLEEALEAE KPSGIHVFAV LLHAHLAGRG
401IRLR HFRKG KEMKLLAYDD DFDFNFQEFQ YLKEEQTILP
441GDNLITECRY NTKDRAEMTW GGLSTRSEMC LSYLLYYPRI
481NLTRC ASIP DIMEQLQFIG VKEIYRPVTT WPFIIKSPKQ
521YKNLSFMDAM NKFKWTKKEG LSFNKLVLSL PVNVRCSKTD
561NAEWSI QGM TALPPDIERP YKAEPLVCGT SSSSSLHRDF
601SINLLVCLLL LSCTLSTKSL
Structure predicted by AlphaFold DB(UniProt: Q6UVY6). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of MOXD1:           Showing partial SNPs
rs15017       rs584864       rs589756       rs591109       rs598597       rs598762       rs599660       rs604196       rs604350       rs605507       rs607137       rs607625       rs611273       rs626471       rs627460       rs628227       rs636124      

Gene Expression

Gene Expression

Tissue expression of MOXD1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CTGTTAGGGAGGTTGAGAGG
59
CTTCCAGAGCCTCTTCCAG
60
GTGATGCGAAGTGTCTTCAG
59
GTTCCAAGCACTTCCTCAG
59
GTATAACGGATAGCACTGTGAG
59
AGTCATGGTACTTGGGACC
59
CTCTTCCATACCATCCCTCC
59
CTTCCAGAGCCTCTTCCAG
60
GTATAACGGATAGCACTGTGAG
59
AGTCATGGTACTTGGGACC
59
TGATGCGAAGTGTCTTCAG
58
GTTCCAAGCACTTCCTCAG
59
TGTAATAAAGGTTGAGCCAGTG
59
TTGTTGCTGCACTGATAGAG
58
GTTAGGGAGGTTGAGAGGC
60
CTTCCAGAGCCTCTTCCAG
60
TGTAATAAAGGTTGAGCCAGTG
59
TTGTTGCTGCACTGATAGAG
58
TCTTCCATACCATCCCTCCA
60
CTTCCAGAGCCTCTTCCAG
60

Gene Ontology

Subcellular localization of MOXD1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MOXD1:

GO ID
Protein
Source DB
GO:0055114
A6PVS1 (UniProtKB)
IEA
GO:0005507
Q6UVY6 (UniProtKB)
IEA
GO:0005515
Q6UVY6 (UniProtKB)
IPI
GO:0005789
Q6UVY6 (UniProtKB)
IDA
GO:0016021
Q6UVY6 (UniProtKB)
IEA
GO:0016715
Q6UVY6 (UniProtKB)
IEA
GO:0055114
Q6UVY6 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating MOXD1:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Obesity 0.12 1 1 GWASCAT

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Li M, Zhang J, Yang Y, Tian S, Cheng X, Li Q, Li P, Zhou S, Shen H, Liu Z, Mao Y, Liu D, Hu Y, Zhang L, Zeng J, Zhang J, Wan J, Zhou J, Fu J, Hu M, Yang H, Bai L, Zhang X, Cai J, She ZG, Wang Y, Li H, Zhang XJ Gut IF: 24.6 2026-05-21
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Li H, Huang C, Su R, Wang M, Ma Y, Wang Y, Xu B, Liu K Comput Biol Med IF: 6.3 2025-09-00
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