MPI (mannose phosphate isomerase)

Gene Basic Information

Gene Basic Information

symbol
MPI
locus group
protein-coding gene
location
15q24.1
gene_family
-
alias symbol
-
alias name
mannose-6-phosphate isomerase
entrez id
4351
ensembl gene id
ENSG00000178802
ucsc gene id
uc002azc.3
refseq accession
NM_001289155
hgnc_id
HGNC:7216
approved reserved
2001-06-22

Chromosome Location

Chromosome Location

15q24.1

Gene Summary

Gene Summary

ChineseEnglish

Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

OMIM entry for MPI     Wikipedia entry for MPI

Gene Sequence

Gene Sequence

Nucleotide sequence of MPI:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAAPRVFPLS CAVQQYAWGK MGSNSEVARL LASSDPLAQI
41AEDKPYAELW MGTHPRGDAK ILDNRISQKT LSQWIAENQD
81 SLGSKVKDT FNGNLPFLFK VLSVETPLSI QAHPNKELAE
121KLHLQAPQHY PDANHKPEMA IALTPFQGLC GFRPVEEIVT
161F LKKVPEFQ FLIGDEAATH LKQTMSHDSQ AVASSLQSCF
201SHLMKSEKKV VVEQLNLLVK RISQQAAAGN NMEDIFGELL
241LQ LHQQYPG DIGCFAIYFL NLLTLKPGEA MFLEANVPHA
281YLKGDCVECM ACSDNTVRAG LTPKFIDVPT LCEMLSYTPS
321SSK DRLFLP TRSQEDPYLS IYDPPVPDFT IMKTEVPGSV
361TEYKVLALDS ASILLMVQGT VIASTPTTQT PIPLQRGGVL
401FIGA NESVS LKLTEPKDLL IFRACCLL
Structure predicted by AlphaFold DB(UniProt: P34949). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of MPI:           Showing partial SNPs
rs8025447       rs147857784       rs181448611       rs532139611       rs537866261       rs538846150       rs542726314       rs551708687       rs553986550       rs556563850       rs560343872       rs561448906       rs567126023       rs572306796       rs576342258       rs577945806       rs1130741      

Gene Expression

Gene Expression

Tissue expression of MPI:    [UniProt]

Gene expression across tissues

Gene Ontology

Subcellular localization of MPI (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MPI:

GO ID
Protein
Source DB
GO:0004476
B4DYB8 (UniProtKB)
IEA
GO:0005975
B4DYB8 (UniProtKB)
IEA
GO:0008270
B4DYB8 (UniProtKB)
IEA
GO:0009298
B4DYB8 (UniProtKB)
IEA
GO:0004476
F5GX71 (UniProtKB)
IEA
GO:0005975
F5GX71 (UniProtKB)
IEA
GO:0008270
F5GX71 (UniProtKB)
IEA
GO:0009298
F5GX71 (UniProtKB)
IEA
GO:0004476
H3BMZ9 (UniProtKB)
IEA
GO:0005975
H3BMZ9 (UniProtKB)
IEA
GO:0008270
H3BMZ9 (UniProtKB)
IEA
GO:0009298
H3BMZ9 (UniProtKB)
IEA
GO:0004476
H3BN01 (UniProtKB)
IEA
GO:0005975
H3BN01 (UniProtKB)
IEA
GO:0008270
H3BN01 (UniProtKB)
IEA
GO:0009298
H3BN01 (UniProtKB)
IEA
GO:0004476
H3BNY8 (UniProtKB)
IEA
GO:0005975
H3BNY8 (UniProtKB)
IEA
GO:0008270
H3BNY8 (UniProtKB)
IEA
GO:0009298
H3BNY8 (UniProtKB)
IEA
GO:0004476
H3BP57 (UniProtKB)
IEA
GO:0005975
H3BP57 (UniProtKB)
IEA
GO:0008270
H3BP57 (UniProtKB)
IEA
GO:0009298
H3BP57 (UniProtKB)
IEA
GO:0004476
H3BPB8 (UniProtKB)
IEA
GO:0005975
H3BPB8 (UniProtKB)
IEA
GO:0008270
H3BPB8 (UniProtKB)
IEA
GO:0009298
H3BPB8 (UniProtKB)
IEA
GO:0004476
H3BPM5 (UniProtKB)
IEA
GO:0005975
H3BPM5 (UniProtKB)
IEA
GO:0008270
H3BPM5 (UniProtKB)
IEA
GO:0009298
H3BPM5 (UniProtKB)
IEA
GO:0004476
H3BPP3 (UniProtKB)
IEA
GO:0005975
H3BPP3 (UniProtKB)
IEA
GO:0008270
H3BPP3 (UniProtKB)
IEA
GO:0009298
H3BPP3 (UniProtKB)
IEA
GO:0004476
H3BPU7 (UniProtKB)
IEA
GO:0005975
H3BPU7 (UniProtKB)
IEA
GO:0008270
H3BPU7 (UniProtKB)
IEA
GO:0009298
H3BPU7 (UniProtKB)
IEA
GO:0004476
H3BQX0 (UniProtKB)
IEA
GO:0005975
H3BQX0 (UniProtKB)
IEA
GO:0008270
H3BQX0 (UniProtKB)
IEA
GO:0009298
H3BQX0 (UniProtKB)
IEA
GO:0004476
H3BT46 (UniProtKB)
IEA
GO:0005975
H3BT46 (UniProtKB)
IEA
GO:0008270
H3BT46 (UniProtKB)
IEA
GO:0009298
H3BT46 (UniProtKB)
IEA
GO:0004476
H3BT48 (UniProtKB)
IEA
GO:0005975
H3BT48 (UniProtKB)
IEA
GO:0008270
H3BT48 (UniProtKB)
IEA
GO:0009298
H3BT48 (UniProtKB)
IEA
GO:0004476
H3BU66 (UniProtKB)
IEA
GO:0005975
H3BU66 (UniProtKB)
IEA
GO:0008270
H3BU66 (UniProtKB)
IEA
GO:0009298
H3BU66 (UniProtKB)
IEA
GO:0004476
H3BUG1 (UniProtKB)
IEA
GO:0005975
H3BUG1 (UniProtKB)
IEA
GO:0008270
H3BUG1 (UniProtKB)
IEA
GO:0009298
H3BUG1 (UniProtKB)
IEA
GO:0004476
H3BUZ9 (UniProtKB)
IEA
GO:0005975
H3BUZ9 (UniProtKB)
IEA
GO:0008270
H3BUZ9 (UniProtKB)
IEA
GO:0009298
H3BUZ9 (UniProtKB)
IEA
GO:0004476
P34949 (UniProtKB)
TAS
GO:0005829
P34949 (UniProtKB)
TAS
GO:0008270
P34949 (UniProtKB)
IEA
GO:0009298
P34949 (UniProtKB)
IEA
GO:0009298
P34949 (UniProtKB)
TAS
GO:0061611
P34949 (UniProtKB)
IEA
GO:0070062
P34949 (UniProtKB)
IDA
GO:0070062
P34949 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating MPI:     

Gene Interactions

Gene Interactions

String
BioGrid
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Congenital disorder of glycosylation type 1B 0.482442977 13 5 BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT
Congenital Disorders of Glycosylation 0.002714419 10 0 BeFree
Malignant neoplasm of ovary 0.002367032 1 0 GAD
Infection by Cryptococcus neoformans 0.000271442 1 0 BeFree
Hypoglycemia 0.000271442 1 0 BeFree
Pterygium 0.000271442 1 0 BeFree
NEUROTICISM 0.000271442 1 0 BeFree
Oropharynx (excludes nasopharynx) 0.000271442 1 0 BeFree
Recurrent pterygium 0.000271442 1 0 BeFree
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Is 0.000271442 1 0 BeFree

Related Publications

Related Publications

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The Role of the Keratinized Mucosa in Peri-Implant Diseases Onset and Brushing Discomfort: A 10-Year Follow-Up.
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Tailoring inter-core distance of clustered SPIONs using silica spacers for enhanced magnetic particle imaging (MPI).
Horno EU, Mores AJ, Owens LD, Maguire ML, Poptani H, O'Brien L, Giardiello M Nanoscale IF: 5.2 2026-05-21
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