MRPS27 (mitochondrial ribosomal protein S27)

Gene Basic Information

Gene Basic Information

symbol:
MRPS27
locus group:
protein-coding gene
location:
5q13.2
gene_family:
Mitochondrial ribosomal proteins
alias symbol:
KIAA0264
alias name:
None
entrez id:
23107
ensembl gene id:
ENSG00000113048
ucsc gene id:
uc003kbz.5
refseq accession:
NM_015084
hgnc_id:
HGNC:14512
approved reserved:
2001-01-26

Chromosome Location

Chromosome Location

5q13.2

Gene Summary

Gene Summary

ChineseEnglish

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and assist in protein synthesis within the mitochondria. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Unlike prokaryotic ribosomes, which are RNA-rich, mitoribosomes have a protein-to-rRNA ratio of approximately 75%, and they lack 5S rRNA. Due to significant sequence divergence across species, these proteins often share biochemical properties but exhibit low sequence homology, making identification difficult. This gene encodes a protein component of the 28S subunit that likely functions as a partner to death-associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [Provided by RefSeq, Nov 2013]

OMIM entry for MRPS27     Wikipedia entry for MRPS27

Gene Sequence

Gene Sequence

Nucleotide sequence of MRPS27:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAASIVRRGM LLARQVVLPQ LSPAGKRYLL SSAYVDSHKW
41EAREKEHYCL ADLASLMDKT FERKLPVSSL TISRLIDNIS
81 SREEIDHAE YYLYKFRHSP NCWYLRNWTI HTWIRQCLKY
121DAQDKALYTL VNKVQYGIFP DNFTFNLLMD SFIKKENYKD
161A LSVVFEVM MQEAFEVPST QLLSLYVLFH CLAKKTDFSW
201EEERNFGASL LLPGLKQKNS VGFSSQLYGY ALLGKVELQQ
241GL RAVYHNM PLIWKPGYLD RALQVMEKVA ASPEDIKLCR
281EALDVLGAVL KALTSADGAS EEQSQNDEDN QGSEKLVEQL
321DIE ETEQSK LPQYLERFKA LHSKLQALGK IESEGLLSLT
361TQLVKEKLST CEAEDIATYE QNLQQWHLDL VQLIQREQQQ
401REQA KQEYQ AQKAAKASA
结构预测来自 AlphaFold DB（UniProt: Q92552），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of MRPS27:           Showing partial SNPs
rs6831       rs893534       rs904719       rs961466       rs961468       rs1025728       rs1258827       rs1353945       rs1982192       rs1982193       rs1988045       rs2008561       rs2047587       rs2047588       rs2289279       rs2289280       rs2289281      

Gene Expression

Gene Expression

Tissue expression of MRPS27:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TAGAGAAGCGCTCGATGTG
59
GATGTCTAACTGCTCCACCA
59
CCACAAATGGGAAGCAAGAG
59
GAGGAAATGTTGTCTATAAGCCG
59
GAAACAGAGCAGTCCAAGC
59
AGGCACAGGTTTCTATTCTC
57
ACCAAGGCTGAAGAGTCAG
59
ATCACTTGAGGTCAGGAGG
58
TCTACCATAGGATCTTCCGC
58
GAAATGTTGTCTATAAGCCGTG
57
CTTTGAAGTGCCTTCCACC
59
TCCTCTTCCCAACTGAAGTC
59
CTCAATACCTGGAACGATTTAAGAG
59
GAGGGCTGAGAACTTAATGC
58
TACCATAGGATCTTCCGCC
58
GGAAATGTTGTCTATAAGCCGT
58
ACTTCAGTTGGGAAGAGGAG
59
GGAACTGAAACCCACTGAG
58
TAGAGAAGCGCTCGATGTG
59
ATGTCTAACTGCTCCACCAG
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of MRPS27 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MRPS27:

GO ID
Protein
Source DB
GO:0005840
G5EA06 (UniProtKB)
IEA
GO:0005515
Q92552 (UniProtKB)
IPI
GO:0005515
Q92552 (UniProtKB)
IPI
GO:0005739
Q92552 (UniProtKB)
IBA
GO:0005743
Q92552 (UniProtKB)
TAS
GO:0005743
Q92552 (UniProtKB)
TAS
GO:0005743
Q92552 (UniProtKB)
TAS
GO:0005743
Q92552 (UniProtKB)
TAS
GO:0005743
Q92552 (UniProtKB)
TAS
GO:0005743
Q92552 (UniProtKB)
TAS
GO:0005840
Q92552 (UniProtKB)
IEA
GO:0070125
Q92552 (UniProtKB)
TAS
GO:0070126
Q92552 (UniProtKB)
TAS

Related microRNA

Related microRNA

microRNAs potentially regulating MRPS27:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

Association of post-transcriptional regulatory gene single nucleotide polymorphisms with Alzheimer's disease.
Bissar N, Kassir R, Missilmani F, Salem-Sokhn E, El Shamieh S J Alzheimers Dis IF: 3.4 2026-04-00
Anti-MRPS27 Antibody: A Novel Diagnostic Biomarker for Autoimmune Hepatitis Identified via a Human Proteome Microarray.
Wada J, Abe K, Abe N, Sugaya T, Takahata Y, Fujita M, Hayashi M, Nozawa Y, Ohira H Hepatol Res IF: 3.7 2026-07-00
MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins.
Davies Stefan M K, Lopez Sanchez Maria I G, Narsai Reena, Shearwood Anne-Marie J, Razif Muhammad F M, Small Ian D, Whelan James, Rackham Oliver, Filipovska Aleksandra FEBS Lett IF: 3.1 2012-12-28
PPR (pentatricopeptide repeat) proteins in mammals: important aids to mitochondrial gene expression.
Lightowlers Robert N, Chrzanowska-Lightowlers Zofia M A Biochem J IF: 3.9 2008-11-17
Establishment and gene analysis of a cisplatin-resistant cell line, Sa-3R, derived from oral squamous cell carcinoma.
Nakatani Ken, Nakamura Megumi, Uzawa Katsuhiro, Wada Takeshi, Seki Naohiko, Tanzawa Hideki, Fujita Shigeyuki Oncol Rep IF: 4.7 2005-08-26

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