MZF1 (myeloid zinc finger 1)

Gene Basic Information

Gene Basic Information

symbol
MZF1
locus group
protein-coding gene
location
19q13.43
gene_family
Zinc fingers, C2H2-type
alias symbol
ZSCAN6|MZF1B|MZF-1|Zfp98
alias name
None
entrez id
7593
ensembl gene id
ENSG00000099326
ucsc gene id
uc002qtn.4
refseq accession
NM_198055
hgnc_id
HGNC:13108
approved reserved
1990-11-05

Chromosome Location

Chromosome Location

19q13.43

Gene Summary

Gene Summary

ChineseEnglish

MZF1 (Myeloid Zinc Finger 1) is a nuclear-localized transcription factor belonging to the SCAN domain-containing zinc finger protein family, a lineage of regulatory proteins characterized by the presence of a SCAN domain that mediates protein-protein interactions and tandem zinc finger motifs that facilitate sequence-specific DNA binding. Structurally, the MZF1 protein consists of an N-terminal domain responsible for transcriptional activation and a C-terminal region containing multiple zinc finger domains that recognize specific DNA sequences to modulate the transcription of downstream target genes. This gene is predominantly expressed in myeloid lineages, including granulocytes and macrophages, where it plays a critical role in maintaining normal hematopoiesis, cell proliferation, and differentiation. Dysregulation of MZF1 function, whether through mutations that impair DNA binding or transcriptional activity, or through aberrant expression levels, is strongly implicated in the pathogenesis of hematologic malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Specifically, MZF1 overexpression can drive uncontrolled cell proliferation and inhibit differentiation, thereby increasing tumor risk, whereas reduced expression may lead to hematopoietic dysfunction and impaired immune cell development. Beyond hematopoietic disorders, MZF1 is involved in tumor progression in solid cancers, including breast and liver cancer, by regulating key effectors such as the cell cycle regulator Cyclin D1 and apoptosis-related genes, highlighting its broader significance in cellular homeostasis and oncogenesis.

OMIM entry for MZF1     Wikipedia entry for MZF1

Gene Sequence

Gene Sequence

Nucleotide sequence of MZF1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MRPAVLGSPD RAPPEDEGPV MVKLEDSEEE GEAALWDPGP
41EAARLRFRCF RYEEATGPQE ALAQLRELCR QWLRPEVRSK
81 EQMLELLVL EQFLGALPPE IQARVQGQRP GSPEEAAALV
121DGLRREPGGP RRWVTVQVQG QEVLSEKMEP SSFQPLPETE
161P PTPEPGPK TPPRTMQESP LGLQVKEESE VTEDSDFLES
201GPLAATQESV PTLLPEEAQR CGTVLDQIFP HSKTGPEGPS
241WR EHPRALW HEEAGGIFSP GFALQLGSIS AGPGSVSPHL
281HVPWDLGMAG LSGQIQSPSR EGGFAHALLL PSDLRSEQDP
321TDE DPCRGV GPALITTRWR SPRGRSRGRP STGGGVVRGG
361RCDVCGKVFS QRSNLLRHQK IHTGERPFVC SECGRSFSRS
401SHLL RHQLT HTEERPFVCG DCGQGFVRSA RLEEHRRVHT
441GEQPFRCAEC GQSFRQRSNL LQHQRIHGDP PGPGAKPPAP
481PGAPE PPGP FPCSECRESF ARRAVLLEHQ AVHTGDKSFG
521CVECGERFGR RSVLLQHRRV HSGERPFACA ECGQSFRQRS
561NLTQHR RIH TGERPFACAE CGKAFRQRPT LTQHLRVHTG
601EKPFACPECG QRFSQRLKLT RHQRTHTGEK PYHCGECGLG
641FTQVSRL TE HQRIHTGERP FACPECGQSF RQHANLTQHR
681RIHTGERPYA CPECGKAFRQ RPTLTQHLRT HRREKPFACQ
721DCGRRFHQ S TKLIQHQRVH SAE
Structure predicted by AlphaFold DB(UniProt: P28698). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of MZF1:           Showing partial SNPs
rs4801609       rs7256188       rs8100253       rs9677034       rs10402077       rs13344155       rs55800631       rs55987239       rs61012884       rs73068333       rs76582686       rs78318296       rs112048129       rs112495529       rs112663252       rs118127667       rs141066445      

Gene Expression

Gene Expression

Tissue expression of MZF1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AGGACTATGCAGGAATCACC
59
AGACTCCAGGAAATCTGAGTC
59
CATCCTGGGAGACGTAGTC
59
CAAGTCAACCTGAAACCCTC
59
CTAGGACTATGCAGGAATCAC
58
GACTCCAGGAAATCTGAGTC
57
AGATTTCCTGGAGTCTGGG
58
GGAAAGATCTGGTCCAGCA
59
GGTCAGAACACCTACCTCC
59
CCTGCTTATACTTATGTAATCGCC
60
CTAGGACTATGCAGGAATCAC
58
GACTCCAGGAAATCTGAGTC
57
AGGACTATGCAGGAATCACC
59
AGACTCCAGGAAATCTGAGTC
59
AGGACTATGCAGGAATCACC
59
AGACTCCAGGAAATCTGAGTC
59
AGGACTATGCAGGAATCACC
59
AGACTCCAGGAAATCTGAGTC
59
AGGACTATGCAGGAATCACC
59
AGACTCCAGGAAATCTGAGTC
59

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
MZF1
PADI1
Activation
17851584
MYB
MZF1
Unknown
7565760
MZF1
BLMH
Activation
21190945
MZF1
CD34
Unknown
8585946
MZF1
CDH2
Unknown
15541732
MZF1
MMP2
Repression
22846578
MZF1
PIK3R3
Unknown
23509792
MZF1
TERT
Repression
10871406

Gene Ontology

Subcellular localization of MZF1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MZF1:

GO ID
Protein
Source DB
GO:0003700
M0R1U5 (UniProtKB)
IEA
GO:0006355
M0R1U5 (UniProtKB)
IEA
GO:0003700
M0R2C0 (UniProtKB)
IEA
GO:0006355
M0R2C0 (UniProtKB)
IEA
GO:0000122
P28698 (UniProtKB)
IDA
GO:0000978
P28698 (UniProtKB)
IDA
GO:0001077
P28698 (UniProtKB)
IDA
GO:0001078
P28698 (UniProtKB)
IDA
GO:0003700
P28698 (UniProtKB)
NAS
GO:0005515
P28698 (UniProtKB)
IPI
GO:0005634
P28698 (UniProtKB)
IBA
GO:0005634
P28698 (UniProtKB)
IDA
GO:0006355
P28698 (UniProtKB)
IDA
GO:0006366
P28698 (UniProtKB)
IEA
GO:0042803
P28698 (UniProtKB)
IPI
GO:0044212
P28698 (UniProtKB)
IDA
GO:0045944
P28698 (UniProtKB)
IDA
GO:0046872
P28698 (UniProtKB)
IEA

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Loading…
Interacting Gene Interaction Source/Score

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Carcinogenesis 0.001085767 4 0 BeFree
Neoplasm Metastasis 0.000814326 3 0 BeFree
Liver carcinoma 0.000814326 3 0 BeFree
Cervix carcinoma 0.000542884 2 0 BeFree
Malignant tumor of cervix 0.000542884 2 0 BeFree
T-Cell Lymphoma 0.000271442 1 0 BeFree
Mammary Neoplasms 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Colorectal Neoplasms 0.000271442 1 0 BeFree
Secondary malignant neoplasm of liver 0.000271442 1 0 BeFree

Related Publications

Related Publications

ALYREF stabilizes MZF1 via m5C modification to exacerbate cardiac remodeling and atrial fibrillation in heart failure.
Nian S, Zhao L, He X, Xia P, Liu Y, Hua B, Li J, Zhang H Cell Mol Life Sci IF: 6.5 2026-06-06
MZF1-mediated GAPDH overexpression drives glycolytic reprogramming and neuroendocrine progression in advanced prostate cancer.
Liu W, He L, Zhong C, Wang Y, Zhang D, Mirza M, Li B Drug Resist Updat IF: 22.0 2026-08-01
Genetic Variant at 6p21.1 Impairs APOBEC2 in Hypoxic Mitophagy via HIF-1α/BNIP3 in Gastric Cancer.
Zheng Z, Li Q, Gu Y, Gao X, Wang X, Zhang Y, An F, Zhan Q, Yin S, Gao Y, Peng R, Liu L, Zhang E, Zhu M, Chen X, Li G, Xu H, Jin G, Yan C Cancer Res Treat IF: 4.2 2026-05-12
UDP-glucuronate decarboxylase 1 promotes tumor immune evasion by accelerating KMT2D loss in hepatocellular carcinoma.
Zhang J, Li Y, Chen J, Ma F, Feng B, Zhou S, Cai Y, Sun Y, Gao Z, Dong E, Fan J, Fu X, Li Z, Ding Z J Immunother Cancer 2026-07-08
Dual Regulatory Functions of Classical Zinc Finger Clusters from Myeloid Zinc Finger-1.
Hwang Y, Park Y, Park N, Noh H, Kang HG, Lee SJ Chemistry IF: 3.6 2026-07-03
MZF1-AS1/NSUN2 promotes the peritoneal metastasis of gastric cancer by enhancing the stability of RAB13 mRNA.
Zhang Q, Zhang R, Liu L, Shen Y, Huo X, Nan Y, Zhang X, Chai J, Hao J Gastric Cancer IF: 6.1 2026-01-00
Correction: MZF1 mediates oncogene-induced senescence by promoting the transcription of p16INK4A.
Wu D, Tan H, Su W, Cheng D, Wang G, Wang J, Ma DA, Dong GM, Sun P Oncogene IF: 9.1 2025-02-00
Myeloid Zinc Finger 1: insights into its oncogenic potential, prognostic value, and impact on immune microenvironment across cancers.
Tian W, Yu C, Xu X, Li J, Peng S, Sun A, Zhang S, Jiang C Front Immunol IF: 7.0 2025-00-00

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