MDK (midkine)

Gene Basic Information

Gene Basic Information

symbol
MDK
locus group
protein-coding gene
location
11p11.2
gene_family
-
alias symbol
MK|FLJ27379
alias name
None
entrez id
4192
ensembl gene id
ENSG00000110492
ucsc gene id
uc031qav.2
refseq accession
NM_001012334
hgnc_id
HGNC:6972
approved reserved
1991-07-10

Chromosome Location

Chromosome Location

11p11.2

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

OMIM entry for MDK     Wikipedia entry for MDK

Gene Sequence

Gene Sequence

Nucleotide sequence of MDK:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW
41AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF
81 GADCKYKFE NWGACDGGTG TKVRQGTLKK ARYNAQCQET
121IRVTKPCTPK TKAKAKAKKG KGKD
Structure predicted by AlphaFold DB(UniProt: P21741). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of MDK:           Showing partial SNPs
rs550703455       rs3832759       rs61882687       rs73466027       rs75505185       rs76185627       rs76583617       rs76614572       rs77301402       rs114912367       rs116789080       rs142962841       rs146351680       rs147877589       rs148565335       rs150701212       rs150701645      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AGATAAGGTGAAGAAGGGCG
60
TCCTTCTTCCAGTTGCAGG
60
CTACAATGCTCAGTGCCAG
59
TTCCCTTTCTTGGCTTTGG
58
CTAGTGTTGGGAGGAGGTC
59
CCTTTCTTGGCTGAGAAGC
59
GATAAGGTGAAGAAGGGCG
58
CTCCTTCTTCCAGTTGCAG
58
TCTAGTGTTGGGAGGAGGT
59
CTTTCTTGGCTGAGAAGCG
59
GGAAGAAGGAGTTTGGAGC
58
TTCCCTTTCTTGGCTTTGG
58
GATAAGGTGAAGAAGGGCG
58
TCCTTCTTCCAGTTGCAGG
60
GAAGAAGGAGTTTGGAGCC
58
TTCCCTTTCTTGGCTTTGG
58
CTAGTGTTGGGAGGAGGTC
59
CTTTCTTGGCTGAGAAGCG
59

Gene Ontology

Subcellular localization of MDK (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MDK:

GO ID
Protein
Source DB
GO:0008083
C9JHA4 (UniProtKB)
IEA
GO:0008083
E9PLM6 (UniProtKB)
IEA
GO:0008083
E9PPJ5 (UniProtKB)
IEA
GO:0001662
P21741 (UniProtKB)
IEA
GO:0005576
P21741 (UniProtKB)
TAS
GO:0005737
P21741 (UniProtKB)
IEA
GO:0007165
P21741 (UniProtKB)
NAS
GO:0007219
P21741 (UniProtKB)
TAS
GO:0007399
P21741 (UniProtKB)
NAS
GO:0007614
P21741 (UniProtKB)
IEA
GO:0008083
P21741 (UniProtKB)
NAS
GO:0008201
P21741 (UniProtKB)
IDA
GO:0009611
P21741 (UniProtKB)
ISS
GO:0016477
P21741 (UniProtKB)
IEA
GO:0021542
P21741 (UniProtKB)
IEA
GO:0021681
P21741 (UniProtKB)
IEA
GO:0021987
P21741 (UniProtKB)
IEA
GO:0030154
P21741 (UniProtKB)
NAS
GO:0030325
P21741 (UniProtKB)
ISS
GO:0030421
P21741 (UniProtKB)
IEA
GO:0042493
P21741 (UniProtKB)
IEA
GO:0042995
P21741 (UniProtKB)
IEA
GO:0043524
P21741 (UniProtKB)
IEA
GO:0045893
P21741 (UniProtKB)
IEA
GO:0050795
P21741 (UniProtKB)
IEA
GO:0051384
P21741 (UniProtKB)
IEA
GO:0051781
P21741 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating MDK:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Glioma 0.123538676 4 0 BeFree_CTD_human_LHGDN
Diabetic Nephropathy 0.12272435 1 0 CTD_human_LHGDN
Anxiety Disorders 0.12 1 0 CTD_human
Memory Disorders 0.12 1 0 CTD_human
Myocardial Infarction 0.082995792 2 0 BeFree_LHGDN_RGD
Schizophrenia 0.080271442 1 0 BeFree_MGD
Coronary Stenosis 0.08 1 0 RGD
Brain Infarction 0.08 1 0 RGD
Squamous cell carcinoma 0.008987376 5 0 BeFree_LHGDN
Liver carcinoma 0.006524536 14 0 BeFree_LHGDN

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