NDEL1基因详情-基因数据库-基因云馆

NDEL1 (nudE neurodevelopment protein 1 like 1)

symbol:: NDEL1
locus group:: protein-coding gene
location:: 17p13.1
gene_family:
alias symbol:: NUDEL|MITAP1|NDE1L1|NDE2
alias name:: None
entrez id:: 81565
ensembl gene id:: ENSG00000166579
ucsc gene id:: uc060bbs.1
refseq accession:: NM_030808
hgnc_id:: HGNC:17620
approved reserved:: 2003-04-10

17p13.1

NDEL1（Nuclear Distribution Element-Like 1）是一种在细胞分裂和神经发育中起关键作用的基因，编码的蛋白质参与微管组织、纺锤体形成和神经元迁移。其主要作用位点包括中心体和微管，通过与LIS1和动力蛋白复合物相互作用，调控有丝分裂和神经元的正确定位。NDEL1的突变可能导致细胞分裂异常或神经元迁移障碍，与多种神经系统疾病相关，如小头畸形、精神分裂症和自闭症谱系障碍。该基因属于NDE1/NDEL1基因家族，家族成员均参与微管动力学和细胞分裂调控，共性包括与LIS1蛋白结合并影响神经发育过程。NDEL1过表达可能导致微管过度稳定化，干扰纺锤体功能，引发染色体分离错误或细胞周期停滞；而表达降低则可能破坏神经元迁移，导致大脑皮层结构异常。此外，NDEL1还参与初级纤毛的形成，其功能异常可能影响Hedgehog信号通路。在疾病关联方面，NDEL1表达异常与精神障碍和神经退行性疾病有关，其蛋白水平变化可能通过影响突触可塑性参与认知功能障碍。该基因在胚胎发育中高表达，成年后主要存在于神经系统中，表明其对神经系统的持续重要性。

中文English

这个基因编码，播放在多个过程，包括细胞骨架组织，细胞信号传导和神经元迁移，增生和维护一个角色的卷曲螺旋蛋白质。可变剪接转录物变体编码的多个同种型已经观察到这种基因，并且该基因的假基因位于染色体X的[通过的RefSeq，2012年3月提供]的长臂

OMIM数据库中对NDEL1基因的介绍 Wikipedia数据库中对NDEL1基因的介绍

NDEL1基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MDGEDIPDFS SLKEETAYWK ELSLKYKQSF QEARDELVEF
41QEGSRELEAE LEAQLVQAEQ RNRDLQADNQ RLKYEVEALK
81
EKLEHQYAQ SYKQVSVLED DLSQTRAIKE QLHKYVRELE
121QANDDLERAK RATIVSLEDF EQRLNQAIER NAFLESELDE
161K
ESLLVSVQ RLKDEARDLR QELAVRERQQ EVTRKSAPSS
201PTLDCEKMDS AVQASLSLPA TPVGKGTENT FPSPKAIPNG
241FG
TSPLTPS ARISALNIVG DLLRKVGALE SKLAACRNFA
281KDQASRKSYI SGNVNCGVLN GNGTKFSRSG HTSFFDKGAV
321NGF
DPAPPP PGLGSSRPSS APGMLPLSV

结构预测来自 AlphaFold DB（UniProt: Q9GZM8），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

NDEL1基因的碱基突变：仅显示部分snp

rs8852 rs185604 rs190591 rs903486 rs903487 rs931672 rs1024067 rs1027375 rs1391766 rs1391768 rs1874917 rs2012190 rs2030125 rs2030128 rs2047488 rs2201466 rs2220870

NDEL1基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GATGAAGCAAGAGATTTAAGGC

58

TAGAGTTGGAGAGCTAGGAG

57

TTTCTTCGACAAAGGCAGAG

59

CCATAATTATTGAGGACGGCAG

59

GATGAAGCAAGAGATTTAAGGC

58

TAGAGTTGGAGAGCTAGGAG

57

GTAGTTTCTTAGGTAACATGTGCTC

60

GTCAAAGCCGTTTACTGCC

60

GGCACAATTAGTACAGGCTG

59

CCAGTATTGATATCGCGCAG

59

CACATTGGAGAAGACCACG

59

GATACAAAGCGACAGGAGG

58

TGATCTCATCAGCCAGAGC

59

GACAGAGCAAGCTTCAAGG

59

AAGTATAAGCAAAGCTTCCAGG

59

CCAACTCTGCTTCTAATTCTCTG

59

GAAGTACCCATTCATCACACC

59

CTAAATCCTATCAGTACAGCAGAG

58

CAGGCTGAACAAAGAAATAGAG

57

CTAGCTTCTCCTTTAATGCCT

57

尚未收录相关数据

NDEL1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

NDEL1基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000132

Q9GZM8 (UniProtKB)

IBA

GO:0000776

Q9GZM8 (UniProtKB)

IDA

GO:0000777

Q9GZM8 (UniProtKB)

IEA

GO:0001764

Q9GZM8 (UniProtKB)

IEA

GO:0001833

Q9GZM8 (UniProtKB)

IEA

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005515

Q9GZM8 (UniProtKB)

IPI

GO:0005635

Q9GZM8 (UniProtKB)

IEA

GO:0005813

Q9GZM8 (UniProtKB)

IBA

GO:0005819

Q9GZM8 (UniProtKB)

IEA

GO:0005829

Q9GZM8 (UniProtKB)

TAS

GO:0005829

Q9GZM8 (UniProtKB)

TAS

GO:0005829

Q9GZM8 (UniProtKB)

TAS

GO:0005829

Q9GZM8 (UniProtKB)

TAS

GO:0005829

Q9GZM8 (UniProtKB)

TAS

GO:0005829

Q9GZM8 (UniProtKB)

TAS

GO:0005829

Q9GZM8 (UniProtKB)

TAS

GO:0005829

Q9GZM8 (UniProtKB)

TAS

GO:0005829

Q9GZM8 (UniProtKB)

TAS

GO:0005829

Q9GZM8 (UniProtKB)

TAS

GO:0005871

Q9GZM8 (UniProtKB)

IBA

GO:0005874

Q9GZM8 (UniProtKB)

IEA

GO:0006508

Q9GZM8 (UniProtKB)

IEA

GO:0007020

Q9GZM8 (UniProtKB)

IBA

GO:0007059

Q9GZM8 (UniProtKB)

IMP

GO:0007062

Q9GZM8 (UniProtKB)

TAS

GO:0007100

Q9GZM8 (UniProtKB)

IBA

GO:0008017

Q9GZM8 (UniProtKB)

IBA

GO:0008021

Q9GZM8 (UniProtKB)

IEA

GO:0008090

Q9GZM8 (UniProtKB)

IEA

GO:0010975

Q9GZM8 (UniProtKB)

IBA

GO:0016477

Q9GZM8 (UniProtKB)

IBA

GO:0021799

Q9GZM8 (UniProtKB)

IEA

GO:0021955

Q9GZM8 (UniProtKB)

IEA

GO:0031252

Q9GZM8 (UniProtKB)

IEA

GO:0033157

Q9GZM8 (UniProtKB)

IMP

GO:0043014

Q9GZM8 (UniProtKB)

IEA

GO:0043203

Q9GZM8 (UniProtKB)

IEA

GO:0043547

Q9GZM8 (UniProtKB)

IMP

GO:0045773

Q9GZM8 (UniProtKB)

IEA

GO:0047496

Q9GZM8 (UniProtKB)

IBA

GO:0048487

Q9GZM8 (UniProtKB)

IEA

GO:0048680

Q9GZM8 (UniProtKB)

IEA

GO:0051081

Q9GZM8 (UniProtKB)

IEA

GO:0051303

Q9GZM8 (UniProtKB)

IBA

GO:0051642

Q9GZM8 (UniProtKB)

IBA

GO:0060052

Q9GZM8 (UniProtKB)

IEA

GO:0060053

Q9GZM8 (UniProtKB)

IEA

GO:0070012

Q9GZM8 (UniProtKB)

IEA

GO:0090630

Q9GZM8 (UniProtKB)

IEA

GO:1904115

Q9GZM8 (UniProtKB)

IEA

GO:1990138

Q9GZM8 (UniProtKB)

IEA

可能调控 NDEL1基因的相关microRNA：

hsa-miR-103 hsa-miR-130b hsa-miR-19b hsa-miR-30a hsa-miR-93 hsa-miR-125a-5p

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

Reactomepathway

名称
Cell Cycle
Cell Cycle, Mitotic
M Phase
Mitotic Anaphase
Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Resolution of Sister Chromatid Cohesion
RHO GTPase Effectors
RHO GTPases Activate Formins
Separation of Sister Chromatids
Signaling by Rho GTPases

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Juvenile arthritis	0.120814326	4	0	BeFree_CTD_human
Schizophrenia	0.012539865	11	0	BeFree_GAD_LHGDN
Juvenile rheumatoid arthritis	0.001357209	5	0	BeFree
Iridocyclitis	0.000542884	2	0	BeFree
Arthritis	0.000271442	1	0	BeFree
Iritis	0.000271442	1	0	BeFree
Miller Dieker syndrome	0.000271442	1	0	BeFree
Disorder of eye	0.000271442	1	0	BeFree
Neuroblastoma	0.000271442	1	0	BeFree
Central neuroblastoma	0.000271442	1	0	BeFree

Increased serum neurodevelopmental biomarker Ndel1 activity in medicated patients with depression is associated with reduced neurite density and neuronal viability independently of intracellular Ndel1 activity.

de Farias IS, Oyadomari WY, Parra LR, Ximenes AP, Cordeiro Júnior Q, Fidalgo TM, Hayashi MAF J Affect Disord IF: 5.7 2026-08-01

Nuclear distribution element-like 1 is associated with dentate gyrus remodeling after status epilepticus in a pilocarpine-induced mouse model.

Xu J, Zhu L, Chen L, Du X, Xu Y, Wu Q Neuroscience IF: 3.3 2026-08-13

Chromosomal instability and chromosome 17p loss drive convergent NDE1 synthetic lethality in metastatic cancer cells.

Teddy CM, Hoj JP, Caci J, Lu M, Killarney ST, Ben-Yishay T, Ben-David U, Wood KC bioRxiv 2026-02-12

Protein-Protein and Peptide-Protein Interactions of NudE-Like 1 (Ndel1): A Protein Involved in Schizophrenia.

Hayashi M A F, Felicori L F, Fresqui M A C, Yonamine C M Curr Protein Pept Sci IF: 2.4 2016-05-30

Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein.

Klinman Eva, Holzbaur Erika L F Cell Rep IF: 6.9 2016-05-12

Half-life of DISC1 protein and its pathological significance under hypoxia stress.

Barodia Sandeep Kumar, Park Sang Ki, Ishizuka Koko, Sawa Akira, Kamiya Atsushi Neurosci Res IF: 3.2 2016-03-21

GSK-3β Phosphorylation of Cytoplasmic Dynein Reduces Ndel1 Binding to Intermediate Chains and Alters Dynein Motility.

Gao Feng J, Hebbar Sachin, Gao Xu A, Alexander Michael, Pandey Jai P, Walla Michael D, Cotham William E, King Stephen J, Smith Deanna S Traffic IF: 2.8 2016-06-17

Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis.

Ota Vanessa Kiyomi, Noto Cristiano, Santoro Marcos Leite, Spindola Leticia Maria, Gouvea Eduardo Sauerbronn, Carvalho Carolina Muniz, Santos Camila Maurício, Xavier Gabriela, Higuchi Cinthia Hiroko, Yonamine Camila, Moretti Patricia Natalia, Abílio Vanessa Costhek, Hayashi Mirian Akemi F, Brietzke Elisa, Gadelha Ary, Cordeiro Quirino, Bressan Rodrigo Affonseca, Belangero Sintia Iole Eur Neuropsychopharmacol IF: 8.1 2016-10-05

Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.

Inaba Hironori, Goto Hidemasa, Kasahara Kousuke, Kumamoto Kanako, Yonemura Shigenobu, Inoko Akihito, Yamano Shotaro, Wanibuchi Hideki, He Dongwei, Goshima Naoki, Kiyono Tohru, Hirotsune Shinji, Inagaki Masaki J Cell Biol IF: 6.1 2016-08-01

Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment.

Kuijpers Marijn, van de Willige Dieudonnée, Freal Amélie, Chazeau Anaël, Franker Mariella A, Hofenk Jasper, Rodrigues Ricardo J Cordeiro, Kapitein Lukas C, Akhmanova Anna, Jaarsma Dick, Hoogenraad Casper C Neuron IF: 16.9 2016-06-28

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NDEL1 (nudE neurodevelopment protein 1 like 1)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

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