NDUFB2-AS1 (NDUFB2 antisense RNA 1)

symbol
NDUFB2-AS1
locus group
non-coding RNA
location
7q34
gene_family
-
alias symbol
-
alias name
None
entrez id
100134713
ensembl gene id
ENSG00000240889
ucsc gene id
uc011krf.1
refseq accession
NR_024454
hgnc_id
HGNC:40396
approved reserved
2012-06-30
7q34

NDUFB2-AS1是一个长链非编码RNA(lncRNA)基因,位于人类染色体7q32.1区域,与NDUFB2基因的反义链重叠。NDUFB2-AS1本身不编码蛋白质,但可能通过调控邻近基因NDUFB2的表达或其他机制发挥生物学功能。NDUFB2是线粒体复合物I(NADH脱氢酶复合物)的一个亚基,参与细胞能量代谢中的氧化磷酸化过程。NDUFB2-AS1可能通过顺式或反式作用影响NDUFB2的表达或稳定性,从而间接调控线粒体功能。研究表明,NDUFB2-AS1在多种癌症中异常表达,例如在肝癌中高表达可能促进肿瘤细胞增殖和转移,而在某些其他癌症中低表达可能与不良预后相关。其具体作用机制可能涉及与microRNA或蛋白质的相互作用,调控下游信号通路如Wnt/β-catenin或PI3K/AKT。NDUFB2-AS1属于非编码RNA基因家族,这类RNA通常不编码蛋白质但可通过表观遗传、转录或转录后调控影响基因表达。NDUFB2-AS1过表达可能破坏线粒体功能平衡导致细胞代谢异常,而低表达可能影响NDUFB2的正常调控,进而干扰能量代谢。目前关于NDUFB2-AS1的研究仍在探索阶段,其精确功能和临床意义需要进一步验证。

Nucleotide sequence of NDUFB2-AS1:[NCBI]
Loading Gene Browser...
SNP variants of NDUFB2-AS1:           Showing partial SNPs
rs73736521       rs150643841       rs184023766       rs185593500       rs188625215       rs190518693       rs192998320       rs202005282       rs531026330       rs533358625       rs535125820       rs539388898       rs541146384       rs557628532       rs563929094       rs567390267       rs568111033      

Tissue expression of NDUFB2-AS1:    [UniProt]

Gene expression across tissues
Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AATCTCTGTCCACCTAAACCA
58
CAGGATAAAGTTCCTCATTCCTG
59
GAATCTCTGTCCACCTAAACC
58
AGGATAAAGTTCCTCATTCCTG
57
CAGAGTCGCTCATCTCCAG
59
ACAGCTAATCTGGGTCAGG
58

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