NDUFB2 (NADH:ubiquinone oxidoreductase subunit B2)

Gene Basic Information

Gene Basic Information

symbol
NDUFB2
locus group
protein-coding gene
location
7q34
gene_family
Mitochondrial complex I: NADH dehydrogenase (ubiquinone) subunits
alias symbol
AGGG|CI-AGGG
alias name
NADH-ubiquinone oxidoreductase AGG…
entrez id
4708
ensembl gene id
ENSG00000090266
ucsc gene id
uc064ipf.1
refseq accession
NM_004546
hgnc_id
HGNC:7697
approved reserved
1996-11-15

Chromosome Location

Chromosome Location

7q34

Gene Summary

Gene Summary

ChineseEnglish

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]

OMIM entry for NDUFB2     Wikipedia entry for NDUFB2

Gene Sequence

Gene Sequence

Nucleotide sequence of NDUFB2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MSALTRLASF ARVGGRLFRS GCARTAGDGG VRHAGGGVHI
41EPRYRQFPQL TRSQVFQSEF FSGLMWFWIL WRFWHDSEEV
81 LGHFPYPDP SQWTDEELGI PPDDED
Structure predicted by AlphaFold DB(UniProt: O95178). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of NDUFB2:           Showing partial SNPs
rs1046515       rs55922126       rs73736521       rs76105862       rs141845048       rs147782813       rs149060142       rs150643841       rs184023766       rs185593500       rs186742053       rs188625215       rs190518693       rs191492791       rs192998320       rs199846947       rs200625749      

Gene Expression

Gene Expression

Tissue expression of NDUFB2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GATCCCAGGTGTTCCAGAG
60
ATACGGAAAGTGACCCAGC
60
AGTATGTCCGCTCTGACTC
59
CATGTTGCTAGCTTGACGG
59
TGTGGTTCTGGATTCTCTGG
60
ATACGGAAAGTGACCCAGC
60
GATCCCAGGTGTTCCAGAG
60
ATACGGAAAGTGACCCAGC
60
GATCCCAGGTGTTCCAGAG
60
ATACGGAAAGTGACCCAGC
60
TGTGGTTCTGGATTCTCTGG
60
ATACGGAAAGTGACCCAGC
60
TGTGGTTCTGGATTCTCTGG
60
ATACGGAAAGTGACCCAGC
60
GGACAGATGAAGAATTAGGTATCC
59
ACCTGGCTCTTGTACAGAG
59
GATCCCAGGTGTTCCAGAG
60
ATACGGAAAGTGACCCAGC
60
TGTGGTTCTGGATTCTCTGG
60
ATACGGAAAGTGACCCAGC
60

Gene Ontology

Subcellular localization of NDUFB2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for NDUFB2:

GO ID
Protein
Source DB
GO:0005747
C9IZW8 (UniProtKB)
IEA
GO:0005747
C9IZZ2 (UniProtKB)
IEA
GO:0005747
C9JXM4 (UniProtKB)
IEA
GO:0005747
H7C5B8 (UniProtKB)
IEA
GO:0005743
O95178 (UniProtKB)
TAS
GO:0005743
O95178 (UniProtKB)
TAS
GO:0005743
O95178 (UniProtKB)
TAS
GO:0005743
O95178 (UniProtKB)
TAS
GO:0005743
O95178 (UniProtKB)
TAS
GO:0005743
O95178 (UniProtKB)
TAS
GO:0005743
O95178 (UniProtKB)
TAS
GO:0005747
O95178 (UniProtKB)
IDA
GO:0005747
O95178 (UniProtKB)
NAS
GO:0006120
O95178 (UniProtKB)
NAS
GO:0006120
O95178 (UniProtKB)
TAS
GO:0008137
O95178 (UniProtKB)
NAS
GO:0032981
O95178 (UniProtKB)
TAS

Related microRNA

Related microRNA

microRNAs potentially regulating NDUFB2:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Ischemia 0.00272435 1 0 LHGDN
Reperfusion Injury 0.00272435 1 0 LHGDN
Malignant neoplasm of prostate 0.002638474 2 0 BeFree_GAD
Prostate carcinoma 0.000271442 1 0 BeFree
Hepatitis B 0.000271442 1 0 BeFree
Precocious pubarche 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
Graves Disease 0.000271442 1 0 BeFree
Carpal Tunnel Syndrome 0.000271442 1 5 BeFree
Schistosomiasis 0.000271442 1 0 BeFree

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