NECAB2 (N-terminal EF-hand calcium binding protein 2)

基因基本信息

基因基本信息

symbol:
NECAB2
locus group:
protein-coding gene
location:
16q23.3
gene_family:
N-terminal EF-hand calcium binding proteins|EF-hand domain containing
alias symbol:
None
alias name:
None
entrez id:
54550
ensembl gene id:
ENSG00000103154
ucsc gene id:
uc002fhd.4
refseq accession:
NM_019065
hgnc_id:
HGNC:23746
approved reserved:
2004-01-27

基因染色体位置

基因染色体位置

16q23.3

基因简述

基因简述

NECAB2（N-terminal EF-hand calcium-binding protein 2）是一种钙结合蛋白，属于NECAB基因家族，该家族还包括NECAB1和NECAB3。NECAB家族成员共同特点是含有N端的EF-hand结构域，能够结合钙离子，参与细胞内钙信号传导。NECAB2主要在中枢神经系统表达，特别是在大脑的神经元中，其表达产物通过与钙离子结合调节突触可塑性和神经递质释放，影响神经元之间的信号传递。NECAB2还参与调控突触后密度蛋白的组装，对维持突触结构和功能稳定性具有重要作用。突变或表达异常可能导致钙信号紊乱，进而影响神经元的正常活动，与某些神经系统疾病如精神分裂症、自闭症谱系障碍和阿尔茨海默病等存在潜在关联。研究表明，NECAB2过表达可能增强突触可塑性，但过度激活钙信号通路可能导致神经元过度兴奋甚至凋亡；而降低表达则可能损害突触功能，影响学习和记忆等认知能力。此外，NECAB2与其他钙调蛋白如钙调素（calmodulin）存在相互作用，共同调节下游信号通路。NECAB2的表达水平还可能影响神经发育相关基因的转录，如BDNF（脑源性神经营养因子）。总体而言，NECAB2通过钙离子依赖的机制在神经系统中发挥关键作用，其表达失衡可能对神经功能产生广泛影响。

中文English

无

OMIM数据库中对NECAB2基因的介绍     Wikipedia数据库中对NECAB2基因的介绍

基因序列

基因序列

NECAB2基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MCERAARLCR AGAHRLLREP PQQGRALGGL LRWVGARMGE
41PRESLAPAAP ADPGPASPRG GTAVILDIFR RADKNDDGKL
81 SLEEFQLFF ADGVLNEKEL EDLFHTIDSD NTNHVDTKEL
121CDYFVDHMGD YEDVLASLET LNHSVLKAMG YTKKVYEGGS
161N VDQFVTRF LLKETANQIQ SLLSSVESAV EAIEEQTSQL
201RQNHIKPSHS AAQTWCGSPT PASAPNHKLM AMEQGKTLPS
241AT EDAKEEG LEAQISRLAE LIGRLESKAL WFDLQQRLSD
281EDGTNMHLQL VRQEMAVCPE QLSEFLDSLR QYLRGTTGVR
321NCF HITAVR LSDGFTFVIY EFWETEEAWK RHLQSPLCKA
361FRHVKVDTLS QPEALSRILV PAAWCTVGRD
结构预测来自 AlphaFold DB（UniProt: Q7Z6G3），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

NECAB2基因的碱基突变：           仅显示部分snp
rs3880       rs3881       rs13299       rs173776       rs173777       rs185226       rs253139       rs253140       rs253141       rs253142       rs253143       rs253144       rs733728       rs733729       rs748059       rs889631       rs889632      

基因表达

基因表达

NECAB2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ACTATGAGGATGTCCTGGC
58
CTCATATACCTTCTTGGTATAACCC
58
CTCTCCAGGATCTTGGTGC
59
CTGCACCAAAGTGTCTGTC
59
AGCGAGTTTCTGGACTCTC
59
GCACCAAGATCCTGGAGAG
59
CTATGAGGATGTCCTGGCC
59
CTCATATACCTTCTTGGTATAACCC
58
TGCAAAGGAAGAGGGTCTG
59
GAACCACAGTGCTTTGCTC
59
AGCGAGTTTCTGGACTCTC
59
CACCAAGATCCTGGAGAGG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

NECAB2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

NECAB2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005515
H3BTW2 (UniProtKB)
IPI
GO:0005509
Q7Z6G3 (UniProtKB)
IEA
GO:0005515
Q7Z6G3 (UniProtKB)
IPI
GO:0005737
Q7Z6G3 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 NECAB2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Tobacco Use Disorder 0.004734064 2 0 GAD

基因相关文献

基因相关文献

Protein Predictors of Worsening Cerebral Edema in Traumatic Brain Injury in Critically Ill Patients.
Radabaugh HL, Abdelhak A, Ning K, Jha RM, Rowell SE, Pollock JM, Mendoza E, Rojas Valencia LM, Ferguson AR, Hinson HE bioRxiv 2026-05-26
iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.
Schöndorf David C, Aureli Massimo, McAllister Fiona E, Hindley Christopher J, Mayer Florian, Schmid Benjamin, Sardi S Pablo, Valsecchi Manuela, Hoffmann Susanna, Schwarz Lukas Kristoffer, Hedrich Ulrike, Berg Daniela, Shihabuddin Lamya S, Hu Jing, Pruszak Jan, Gygi Steven P, Sonnino Sandro, Gasser Thomas, Deleidi Michela Nat Commun IF: 12.124 2015-12-03
Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury.
Zhang Ming-Dong, Tortoriello Giuseppe, Hsueh Brian, Tomer Raju, Ye Li, Mitsios Nicholas, Borgius Lotta, Grant Gunnar, Kiehn Ole, Watanabe Masahiko, Uhlén Mathias, Mulder Jan, Deisseroth Karl, Harkany Tibor, Hökfelt Tomas G M Proc Natl Acad Sci U S A IF: 9.5 2014-06-17
Protein interactome reveals converging molecular pathways among autism disorders.
Sakai Yasunari, Shaw Chad A, Dawson Brian C, Dugas Diana V, Al-Mohtaseb Zaina, Hill David E, Zoghbi Huda Y Sci Transl Med IF: 15.6 2011-09-28
From cradle to twilight: the carboxyl terminus directs the fate of the A(2A)-adenosine receptor.
Keuerleber Simon, Gsandtner Ingrid, Freissmuth Michael Biochim Biophys Acta 2011-05-19
The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function.
Canela Laia, Fernández-Dueñas Víctor, Albergaria Catarina, Watanabe Masahiko, Lluís Carme, Mallol Josefa, Canela Enric I, Franco Rafael, Luján Rafael, Ciruela Francisco J Neurochem IF: 4.6 2009-10-22
The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor.
Canela Laia, Luján Rafael, Lluís Carme, Burgueño Javier, Mallol Josefa, Canela Enric I, Franco Rafael, Ciruela Francisco Mol Cell Neurosci IF: 3.4 2007-12-06
Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord.
Zhang Ming-Dong, Barde Swapnali, Szodorai Edit, Josephson Anna, Mitsios Nicholas, Watanabe Masahiko, Attems Johannes, Lubec Gert, Kovács Gábor G, Uhlén Mathias, Mulder Jan, Harkany Tibor, Hökfelt Tomas Brain Struct Funct IF: 3.0 0000-00-00
Identification of p53-target genes in Danio rerio.
Mandriani Barbara, Castellana Stefano, Rinaldi Carmela, Manzoni Marta, Venuto Santina, Rodriguez-Aznar Eva, Galceran Juan, Nieto M Angela, Borsani Giuseppe, Monti Eugenio, Mazza Tommaso, Merla Giuseppe, Micale Lucia Sci Rep IF: 4.9 0000-00-00

基因相关服务

基因相关服务

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基因相关评论

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