NOS2 (nitric oxide synthase 2)

Gene Basic Information

Gene Basic Information

symbol
NOS2
locus group
protein-coding gene
location
17q11.2
gene_family
-
alias symbol
iNOS|NOS|HEP-NOS
alias name
None
entrez id
4843
ensembl gene id
ENSG00000007171
ucsc gene id
uc002gzu.4
refseq accession
NM_000625
hgnc_id
HGNC:7873
approved reserved
1993-06-15

Chromosome Location

Chromosome Location

17q11.2

Gene Summary

Gene Summary

ChineseEnglish

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

OMIM entry for NOS2     Wikipedia entry for NOS2

Gene Sequence

Gene Sequence

Nucleotide sequence of NOS2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MACPWKFLFK TKFHQYAMNG EKDINNNVEK APCATSSPVT
41QDDLQYHNLS KQQNESPQPL VETGKKSPES LVKLDATPLS
81 SPRHVRIKN WGSGMTFQDT LHHKAKGILT CRSKSCLGSI
121MTPKSLTRGP RDKPTPPDEL LPQAIEFVNQ YYGSFKEAKI
161E EHLARVEA VTKEIETTGT YQLTGDELIF ATKQAWRNAP
201RCIGRIQWSN LQVFDARSCS TAREMFEHIC RHVRYSTNNG
241NI RSAITVF PQRSDGKHDF RVWNAQLIRY AGYQMPDGSI
281RGDPANVEFT QLCIDLGWKP KYGRFDVVPL VLQANGRDPE
321LFE IPPDLV LEVAMEHPKY EWFRELELKW YALPAVANML
361LEVGGLEFPG CPFNGWYMGT EIGVRDFCDV QRYNILEEVG
401RRMG LETHK LASLWKDQAV VEINIAVLHS FQKQNVTIMD
441HHSAAESFMK YMQNEYRSRG GCPADWIWLV PPMSGSITPV
481FHQEM LNYV LSPFYYYQVE AWKTHVWQDE KRRPKRREIP
521LKVLVKAVLF ACMLMRKTMA SRVRVTILFA TETGKSEALA
561WDLGAL FSC AFNPKVVCMD KYRLSCLEEE RLLLVVTSTF
601GNGDCPGNGE KLKKSLFMLK ELNNKFRYAV FGLGSSMYPR
641FCAFAHD ID QKLSHLGASQ LTPMGEGDEL SGQEDAFRSW
681AVQTFKAACE TFDVRGKQHI QIPKLYTSNV TWDPHHYRLV
721QDSQPLDL S KALSSMHAKN VFTMRLKSRQ NLQSPTSSRA
761TILVELSCED GQGLNYLPGE HLGVCPGNQP ALVQGILERV
801VDGPTPHQT VRLEALDESG SYWVSDKRLP PCSLSQALTY
841FLDITTPPTQ LLLQKLAQVA TEEPERQRLE ALCQPSEYSK
881WKFTNSPTFL EVLEEFPSL RVSAGFLLSQ LPILKPRFYS
921ISSSRDHTPT EIHLTVAVVT YHTRDGQGPL HHGVCSTWLN
961SLKPQDPVPC F VRNASGFH LPEDPSHPCI LIGPGTGIAP
1001FRSFWQQRLH DSQHKGVRGG RMTLVFGCRR PDEDHIYQEE
1041MLEMAQKGVL HA VHTAYSR LPGKPKVYVQ DILRQQLASE
1081VLRVLHKEPG HLYVCGDVRM ARDVAHTLKQ LVAAKLKLNE
1121EQVEDYFFQL KSQ KRYHED IFGAVFPYEA KKDRVAVQPS
1161SLEMSAL
Structure predicted by AlphaFold DB(UniProt: P35228). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of NOS2:           Showing partial SNPs
rs15782       rs16949       rs944722       rs944723       rs944724       rs944725       rs1060822       rs1060826       rs1060828       rs1113283       rs1137933       rs1137949       rs1799765       rs1800482       rs1962380       rs2072324       rs2248814      

Gene Expression

Gene Expression

Tissue expression of NOS2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TTGAAAGTCTTGGTCAAAGCTG
60
GATGGTGACTCTGACTCGG
60
GAATTCACTCAGCTGTGCA
59
ATTTCGAAGAGCTCAGGGT
59
GGAATTCACTCAGCTGTGC
59
TTTCGAAGAGCTCAGGGTC
59
CCTTCAGTATCACAACCTCAG
58
GATTCTGGAGACTTCTTTCCC
58
ATGACCTTCAGTATCACAACCT
59
CTGGAGACTTCTTTCCCGT
59
GAATTCACTCAGCTGTGCA
59
TTTCGAAGAGCTCAGGGTC
59

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
APC
NOS2
Activation
11935128
FOS
NOS2
Activation
12788789
FOS
NOS2
Repression
9776360
FOSL2
NOS2
Activation
12788789
IKBKB
NOS2
Repression
17478759
JUN
NOS2
Activation
12788789
JUN
NOS2
Repression
9776360
JUN
NOS2
Unknown
14962367
JUND
NOS2
Activation
12788789
KLF6
NOS2
Activation
12590140

Gene Ontology

Subcellular localization of NOS2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for NOS2:

GO ID
Protein
Source DB
GO:0001666
P35228 (UniProtKB)
IEA
GO:0001912
P35228 (UniProtKB)
TAS
GO:0002227
P35228 (UniProtKB)
NAS
GO:0004517
P35228 (UniProtKB)
IDA
GO:0004517
P35228 (UniProtKB)
IDA
GO:0004517
P35228 (UniProtKB)
TAS
GO:0005102
P35228 (UniProtKB)
IPI
GO:0005515
P35228 (UniProtKB)
IPI
GO:0005515
P35228 (UniProtKB)
IPI
GO:0005516
P35228 (UniProtKB)
IEA
GO:0005622
P35228 (UniProtKB)
IDA
GO:0005634
P35228 (UniProtKB)
ISS
GO:0005737
P35228 (UniProtKB)
IDA
GO:0005737
P35228 (UniProtKB)
IDA
GO:0005777
P35228 (UniProtKB)
IDA
GO:0005829
P35228 (UniProtKB)
IMP
GO:0005829
P35228 (UniProtKB)
TAS
GO:0006527
P35228 (UniProtKB)
IDA
GO:0006801
P35228 (UniProtKB)
ISS
GO:0006809
P35228 (UniProtKB)
IDA
GO:0006809
P35228 (UniProtKB)
IDA
GO:0007263
P35228 (UniProtKB)
IBA
GO:0007623
P35228 (UniProtKB)
IEA
GO:0009617
P35228 (UniProtKB)
NAS
GO:0010181
P35228 (UniProtKB)
ISS
GO:0010629
P35228 (UniProtKB)
IGI
GO:0018119
P35228 (UniProtKB)
ISS
GO:0020037
P35228 (UniProtKB)
ISS
GO:0030863
P35228 (UniProtKB)
IEA
GO:0031284
P35228 (UniProtKB)
IBA
GO:0032310
P35228 (UniProtKB)
IDA
GO:0034617
P35228 (UniProtKB)
ISS
GO:0034618
P35228 (UniProtKB)
ISS
GO:0035690
P35228 (UniProtKB)
IEA
GO:0042127
P35228 (UniProtKB)
IEA
GO:0042177
P35228 (UniProtKB)
IEA
GO:0042742
P35228 (UniProtKB)
ISS
GO:0042742
P35228 (UniProtKB)
IMP
GO:0042803
P35228 (UniProtKB)
ISS
GO:0043457
P35228 (UniProtKB)
TAS
GO:0045454
P35228 (UniProtKB)
TAS
GO:0045776
P35228 (UniProtKB)
IBA
GO:0045909
P35228 (UniProtKB)
IBA
GO:0046872
P35228 (UniProtKB)
IEA
GO:0048471
P35228 (UniProtKB)
IEA
GO:0050660
P35228 (UniProtKB)
ISS
GO:0050661
P35228 (UniProtKB)
TAS
GO:0050796
P35228 (UniProtKB)
IMP
GO:0050829
P35228 (UniProtKB)
NAS
GO:0051712
P35228 (UniProtKB)
IMP
GO:0055114
P35228 (UniProtKB)
IEA
GO:0071222
P35228 (UniProtKB)
IEA
GO:0071346
P35228 (UniProtKB)
IEA
GO:0072604
P35228 (UniProtKB)
IDA
GO:0072606
P35228 (UniProtKB)
IDA
GO:1900015
P35228 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating NOS2:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Psoriasis 0.243452799 5 1 BeFree_CTD_human_GAD_GWASCAT
Asthma 0.232723709 31 2 BeFree_CTD_human_GAD_LHGDN_RGD
Diabetes Mellitus, Non-Insulin-Dependent 0.214745076 8 0 BeFree_CTD_human_GAD_RGD
Hypertensive disease 0.209087065 11 0 BeFree_CTD_human_GAD_LHGDN_RGD
Cerebrovascular accident 0.208544182 8 0 BeFree_CTD_human_GAD_LHGDN_RGD
Sepsis 0.201357209 8 1 BeFree_CTD_human_RGD
Colitis 0.200542884 5 0 BeFree_CTD_human_RGD
Asbestosis 0.2 2 0 CTD_human_RGD
Diabetes Mellitus, Experimental 0.2 3 0 CTD_human_RGD
Septic Shock 0.2 2 0 CTD_human_RGD

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