OATGene Detail-Gene Database-Genelibs

OAT (ornithine aminotransferase)

symbol

OAT

locus group

protein-coding gene

location

10q26.13

gene_family

-

alias symbol

HOGA

alias name

Ornithine aminotransferase|ornithi…

entrez id

4942

ensembl gene id

ENSG00000065154

ucsc gene id

uc001lhp.4

refseq accession

NM_000274

hgnc_id

HGNC:8091

approved reserved

2001-06-22

10q26.13

ChineseEnglish

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]

OMIM entry for OAT Wikipedia entry for OAT

Nucleotide sequence of OAT:[NCBI]

Loading Gene Browser...

Protein Sequence

1MFSKLAHLQR FAVLSRGVHS SVASATSVAT KKTVQGPPTS
41DDIFEREYKY GAHNYHPLPV ALERGKGIYL WDVEGRKYFD
81
FLSSYSAVN QGHCHPKIVN ALKSQVDKLT LTSRAFYNNV
121LGEYEEYITK LFNYHKVLPM NTGVEAGETA CKLARKWGYT
161V
KGIQKYKA KIVFAAGNFW GRTLSAISSS TDPTSYDGFG
201PFMPGFDIIP YNDLPALERA LQDPNVAAFM VEPIQGEAGV
241VV
PDPGYLM GVRELCTRHQ VLFIADEIQT GLARTGRWLA
281VDYENVRPDI VLLGKALSGG LYPVSAVLCD DDIMLTIKPG
321EHG
STYGGN PLGCRVAIAA LEVLEEENLA ENADKLGIIL
361RNELMKLPSD VVTAVRGKGL LNAIVIKETK DWDAWKVCLR
401LRDN
GLLAK PTHGDIIRFA PPLVIKEDEL RESIEIINKT
441ILSF

Structure predicted by AlphaFold DB(UniProt: P04181). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

SNP variants of OAT: Showing partial SNPs

rs8182 rs11461 rs1254951 rs1254952 rs1399930 rs1710560 rs1782764 rs1782765 rs1782774 rs1800456 rs1804030 rs2240881 rs2240882 rs2282693 rs2282694 rs2459215 rs2459216

Tissue expression of OAT: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

AGACTGTCCCTAACTCTGG

58

CATCGTAACTGGTTGGGTC

58

CTTCTGATGTTGTAACTGCCG

60

CAAGCATCCCAATCTTTGGT

59

CTTCTGATGTTGTAACTGCCG

60

CAAGCATCCCAATCTTTGGT

59

CCTTTACCTGTAGCCCTGG

60

TTCTGCCTTCTACATCCCA

58

ATACAGACAGGATTGGCCAG

60

TGCAGACACAGGGTATAAGC

60

CCTTTACCTGTAGCCCTGG

60

TTCTGCCTTCTACATCCCA

58

GGATTCGACATCATTCCCT

57

TTTGGATCCTGAAGAGCAC

58

TGAATACAGGAGTGGAGGC

59

ATTTCTGAATGCCCTTCACG

59

GTAACGTGCAGATCTGTGG

59

AAGTACAGCAAACCTCTGC

58

CTCCTAAGTACCAGATACTACAGG

59

CAAGATCCAGGGACAGTCTG

60

Transcription Factors

Target Gene

Interaction Type

PubMed References

SP1

OAT

Unknown

2373169

TFAP2A

OAT

Unknown

2373169

Subcellular localization of OAT (and its protein):

[UniProt] [GenomeNet]

plasma membrane
cytoplasm
extracellular
golgi
vesicle
cytoskeleton
endoplasmic reticulum
nucleus
endosome
lysosome
mitochondrion

Gene Ontology (GO) terms for OAT:

GO ID

Protein

Source DB

GO:0004587

P04181 (UniProtKB)

EXP

GO:0005739

P04181 (UniProtKB)

TAS

GO:0005759

P04181 (UniProtKB)

TAS

GO:0005759

P04181 (UniProtKB)

TAS

GO:0007601

P04181 (UniProtKB)

TAS

GO:0008652

P04181 (UniProtKB)

TAS

GO:0010121

P04181 (UniProtKB)

IBA

GO:0019544

P04181 (UniProtKB)

IBA

GO:0030170

P04181 (UniProtKB)

IBA

GO:0034214

P04181 (UniProtKB)

IDA

GO:0042802

P04181 (UniProtKB)

IBA

GO:0055129

P04181 (UniProtKB)

IEA

microRNAs potentially regulating OAT:

hsa-miR-1 hsa-miR-19a hsa-miR-19a* hsa-miR-27b hsa-miR-27b* hsa-miR-196a hsa-miR-99b

String

BioGrid

IntAct

mentha

MINT

Reactome

Loading…

Interacting Gene	Interaction	Source/Score

KEGG
Reactomepathway

Name
330 Arginine and proline metabolism [PATH:hsa00330]

Name
Amino acid synthesis and interconversion (transamination)
Metabolism of amino acids and derivatives

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
Gyrate Atrophy	0.334039032	44	4	BeFree_CTD_human_GAD_MGD_UNIPROT
Hyperornithinemia	0.242442977	9	60	BeFree_CLINVAR_ORPHANET
Necrotizing Enterocolitis	0.12	1	0	CTD_human
Scotoma	0.002367032	1	0	GAD
Visual field defects	0.002367032	1	0	GAD
Chorioretinal degeneration	0.002171535	8	0	BeFree
Degenerative disorder	0.001628651	6	0	BeFree
Disorder of eye	0.000814326	3	0	BeFree
synovial sarcoma	0.000814326	3	0	BeFree
Unspecified visual loss	0.000814326	3	0	BeFree

Synergistic effects of binary probiotics and oat β-glucan on brown yogurt quality: Physicochemical, flavor, sensory, and metabolomic evaluation.

Wang Z, Zhou X, Wang C, Wang H, Zalán Z, Suo H Food Microbiol IF: 5.4 2027-01-00

Haplotype-Resolved Genomes of Diverse Oat Crown Rust Isolates Reveal Global Dispersion of Long-Lived Clonal Haplotypes with Limited Recombination.

Henningsen EC, Nazareno ES, Spanner R, Lewis D, Lubega J, Moreau EP, Moscou MJ, Boesen B, Stone E, Kanyuka K, Kianian SF, Steffenson BJ, Dodds PN, Sperschneider J, Figueroa M Mol Plant Microbe Interact IF: 3.9 2026-05-00

Insights on the impact of arbuscular mycorrhizal symbiosis on Avena sativa drought tolerance at the early flowering stage.

Tian H, Li J, Liu W, Wang H, Zhang J, Liang X, Liu Y, Hu Y, Yi J, Ji Y, Zhou Q Plant Physiol Biochem IF: 6.2 2026-03-00

Temperature robustness and viscoelasticity of soy protein-stabilized palm oil emulsions containing glycerol monostearate and oat fiber.

Mello NA, Rousseau D J Sci Food Agric IF: 4.0 2026-05-00

Multi-Omics and Molecular Docking Reveal That Oats and Oat Bran Alleviate Chronic Colitis Via IL-17 Pathway Modulation.

Duan W, Li T, Zhang Y, Sun B, Liu RH Nutrients IF: 3.550 2026-01-26

Peer review of the pesticide risk assessment of the active substance cinmethylin.

European Food Safety Authority EFSA, Álvarez F, Arena M, Auteri D, Leite SB, Binaglia M, Castoldi AF, Chiusolo A, Colagiorgi A, Colas M, Crivellente F, De Lentdecker C, De Magistris I, Egsmose M, Fait G, Ferilli F, Santonja GG, Gouliarmou V, Halling K, Ippolito A, Istace F, Kardassi D, Kienzler A, Lanzoni A, Lava R, Leuschner R, Linguadoca A, Romano ML, Louisse J, Lythgo C, Magrans O, Mangas I, Mazzega S, Mioč A, Miron I, Molnar T, Padovani L, Padricello V, Panzarea M, Parra Morte JM, Rizzuto S, Santos M, Serafimova R, Sharp R, Szentes C, Theobald A, Tiramani M, Vianello G, Villamar-Bouza L, Athanasiou D EFSA J 2026-02-00

Exploring allomelanin: A comparative analysis via natural product extraction and synthesis.

Aman S, Irie LM, Su S, Siwicka ZE, La Clair JJ, Kalaj BN, Latawiec EI, Karanjkar P, Wasielewski MR, Dhinojwala A, Burkart MD, Farha OK, Gianneschi NC Sci Adv IF: 12.5 2026-02-13

Impact of Yogurt and Rolled Oats Consumption on the Gut Microbiome: A Randomized Crossover Study Displaying Individual Responses and General Resilience.

Thriene K, Stanislas V, Huang KD, Strowig T, Michels KB J Nutr IF: 4.2 2026-04-00

The dose-response relationship between seminal plasma metal mixtures and oligo-astheno-teratozoospermia: a hospital-based case-control study.

Liu X, Chen C, Chen Y, Xu Y, Qi J, Jiang C, Chen Y J Trace Elem Med Biol IF: 4.1 2026-04-00

Oat grass improves meat tenderness and flavor, reduces fat deposition in small-tailed Han sheep.

Wang LW, Li JQ, An JH, Sun H, Liu F, Zhao MR, Jiang LL, Dong XR, Tao S, Bayaer M, He JF, Liu YB Food Chem (Oxf) IF: 4.8 2026-06-00

View more publications »

Loading comments...

Log in to post comments Log In Sign Up

OAT (ornithine aminotransferase)

Gene Basic Information

Gene Basic Information

Chromosome Location

Chromosome Location

Gene Summary

Gene Summary

Gene Sequence

Gene Sequence

Encoded Protein

Encoded Protein

Gene Variants

Gene Variants

Gene Expression

Gene Expression

Gene Primers

Gene Primers

Transcription Factors

Transcription Factors

Gene Ontology

Related microRNA

Related microRNA

Gene Interactions

Gene Interactions

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Related Publications

Related Publications

Related Services

Related Services

Comments

Comments

Contact

WeChat Official Account