PAPPA (pappalysin 1)

Gene Basic Information

Gene Basic Information

symbol
PAPPA
locus group
protein-coding gene
location
9q33.1
gene_family
Pappalysins
alias symbol
PAPP-A|PAPPA1|IGFBP-4ase|PAPA|ASBABP2|DIPLA1
alias name
insulin-like growth factor-depende…
entrez id
5069
ensembl gene id
ENSG00000182752
ucsc gene id
uc004bjn.4
refseq accession
NM_002581
hgnc_id
HGNC:8602
approved reserved
1992-09-25

Chromosome Location

Chromosome Location

9q33.1

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]

OMIM entry for PAPPA     Wikipedia entry for PAPPA

Gene Sequence

Gene Sequence

Nucleotide sequence of PAPPA:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MRLWSWVLHL GLLSAALGCG LAERPRRARR DPRAGRPPRP
41AAGPATCATR AARGRRASPP PPPPPGGAWE AVRVPRRRQQ
81 REARGATEE PSPPSRALYF SGRGEQLRLR ADLELPRDAF
121TLQVWLRAEG GQRSPAVITG LYDKCSYISR DRGWVVGIHT
161I SDQDNKDP RYFFSLKTDR ARQVTTINAH RSYLPGQWVY
201LAATYDGQFM KLYVNGAQVA TSGEQVGGIF SPLTQKCKVL
241ML GGSALNH NYRGYIEHFS LWKVARTQRE ILSDMETHGA
281HTALPQLLLQ ENWDNVKHAW SPMKDGSSPK VEFSNAHGFL
321LDT SLEPPL CGQTLCDNTE VIASYNQLSS FRQPKVVRYR
361VVNLYEDDHK NPTVTREQVD FQHHQLAEAF KQYNISWELD
401VLEV SNSSL RRRLILANCD ISKIGDENCD PECNHTLTGH
441DGGDCRHLRH PAFVKKQHNG VCDMDCNYER FNFDGGECCD
481PEITN VTQT CFDPDSPHRA YLDVNELKNI LKLDGSTHLN
521IFFAKSSEEE LAGVATWPWD KEALMHLGGI VLNPSFYGMP
561GHTHTM IHE IGHSLGLYHV FRGISEIQSC SDPCMETEPS
601FETGDLCNDT NPAPKHKSCG DPGPGNDTCG FHSFFNTPYN
641NFMSYAD DD CTDSFTPNQV ARMHCYLDLV YQGWQPSRKP
681APVALAPQVL GHTTDSVTLE WFPPIDGHFF ERELGSACHL
721CLEGRILV Q YASNASSPMP CSPSGHWSPR EAEGHPDVEQ
761PCKSSVRTWS PNSAVNPHTV PPACPEPQGC YLELEFLYPL
801VPESLTIWV TFVSTDWDSS GAVNDIKLLA VSGKNISLGP
841QNVFCDVPLT IRLWDVGEEV YGIQIYTLDE HLEIDAAMLT
881STADTPLCLQ CKPLKYKVV RDPPLQMDVA SILHLNRKFV
921DMDLNLGSVY QYWVITISGT EESEPSPAVT YIHGSGYCGD
961GIIQKDQGEQ C DDMNKING DGCSLFCRQE VSFNCIDEPS
1001RCYFHDGDGV CEEFEQKTSI KDCGVYTPQG FLDQWASNAS
1041VSHQDQQCPG WV IIGQPAA SQVCRTKVID LSEGISQHAW
1081YPCTISYPYS QLAQTTFWLR AYFSQPMVAA AVIVHLVTDG
1121TYYGDQKQET ISV QLLDTK DQSHDLGLHV LSCRNNPLII
1161PVVHDLSQPF YHSQAVRVSF SSPLVAISGV ALRSFDNFDP
1201VTLSSCQRGE TYSP AEQSC VHFACEKTDC PELAVENASL
1241NCSSSDRYHG AQCTVSCRTG YVLQIRRDDE LIKSQTGPSV
1281TVTCTEGKWN KQVAC EPVD CSIPDHHQVY AASFSCPEGT
1321TFGSQCSFQC RHPAQLKGNN SLLTCMEDGL WSFPEALCEL
1361MCLAPPPVPN ADLQTA RCR ENKHKVGSFC KYKCKPGYHV
1401PGSSRKSKKR AFKTQCTQDG SWQEGACVPV TCDPPPPKFH
1441GLYQCTNGFQ FNSECRI KC EDSDASQGLG SNVIHCRKDG
1481TWNGSFHVCQ EMQGQCSVPN ELNSNLKLQC PDGYAIGSEC
1521ATSCLDHNSE SIILPMNV T VRDIPHWLNP TRVERVVCTA
1561GLKWYPHPAL IHCVKGCEPF MGDNYCDAIN NRAFCNYDGG
1601DCCTSTVKTK KVTPFPMSC DLQGDCACRD PQAQEHSRKD
1641LRGYSHG
Structure predicted by AlphaFold DB(UniProt: Q13219). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of PAPPA:           Showing partial SNPs
rs1072500       rs1323439       rs1323440       rs1323441       rs1323442       rs1407879       rs1475217       rs1570516       rs1570517       rs1570518       rs1885981       rs1885982       rs1885983       rs1885984       rs1924033       rs1998499       rs2418439      

Gene Expression

Gene Expression

Tissue expression of PAPPA:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TGCTCTGATTCACTGTGTC
58
GGCATCACAATAATTGTCTCC
57
ATACCAAAGATCAGAGCCAC
57
AAATGGCTCTTACTCAGTCTC
58
CAAGTGGTATCCTCACCCT
58
ATTGTCTCCCATGAAGGGC
59
TGAAGCAGAAGGTCATCCTG
60
GGGTTGACAGCTGAATTTGG
60
CAGAGCCACGATCTAGACC
59
GATGGTGACATGTACAACGG
59
TCAGAGCCACGATCTAGAC
58
ATGGTGACATGTACAACGG
57
CCAAAGATCAGAGCCACGA
60
GGAAATGGCTCTTACTCAGTC
59
ATGAGCTATGCAGATGACGA
59
GACCAGGTCCAGGTAACAG
59
AAGTGGTATCCTCACCCTG
58
ATTGTCTCCCATGAAGGGC
59
CTGCTCTGATTCACTGTGTC
59
GCATCACAATAATTGTCTCCCA
59

Gene Ontology

Subcellular localization of PAPPA (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PAPPA:

GO ID
Protein
Source DB
GO:0004222
Q13219 (UniProtKB)
EXP
GO:0004222
Q13219 (UniProtKB)
TAS
GO:0005576
Q13219 (UniProtKB)
IDA
GO:0005576
Q13219 (UniProtKB)
NAS
GO:0005576
Q13219 (UniProtKB)
TAS
GO:0005576
Q13219 (UniProtKB)
TAS
GO:0006508
Q13219 (UniProtKB)
IEA
GO:0007565
Q13219 (UniProtKB)
NAS
GO:0007565
Q13219 (UniProtKB)
NAS
GO:0008237
Q13219 (UniProtKB)
IDA
GO:0008237
Q13219 (UniProtKB)
NAS
GO:0008270
Q13219 (UniProtKB)
NAS
GO:0008270
Q13219 (UniProtKB)
NAS
GO:0044267
Q13219 (UniProtKB)
TAS

Related microRNA

Related microRNA

microRNAs potentially regulating PAPPA:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Acute Coronary Syndrome 0.128987376 7 0 BeFree_CTD_human_LHGDN
Myocardial Infarction 0.1254487 3 0 CTD_human_LHGDN
Female infertility 0.122367032 2 0 CTD_human_GAD
Angina, Unstable 0.120271442 2 0 BeFree_CTD_human
Endometriosis 0.120271442 2 0 BeFree_CTD_human
Coronary Artery Disease 0.12 1 0 CTD_human
Down Syndrome 0.007610304 19 0 BeFree_LHGDN
Lupus Erythematosus, Systemic 0.00272435 1 0 LHGDN
Spontaneous abortion 0.00272435 1 0 LHGDN
Hyperplasia 0.00272435 1 0 LHGDN

Related Publications

Related Publications

Pan-Cancer Analysis of PAPPA Gene Reveals Tumor-Specific Prognostic Effects.
Alfadul SM, Omama K, Potapova AY, Ivanov-Rostovtsev PA, Fanian M, Mubarak R, Gasimelseed HA, Balla MM, Bakhiet AMA, Berma K, Alfaki M, Babak MV Biology (Basel) 2026-03-12
From a Multi-Omics Signature to a Therapeutic Candidate: Computational Prediction and Experimental Validation in Liver Fibrosis.
Qin Y, Ma S, Hong H, Zhong D, Liang Y, Su Y, Chen Y, Chen X, Zhu Y, Huang X Pharmaceuticals (Basel) 2026-03-17
Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals.
Wang H, Nagarajan P, Miller CL, Bentley AR, Noordam R, Westerman KE, Brown MR, Kraja AT, O'Connell JR, Schwander K, Li C, Sanghvi MM, Song Y, Bartz TM, Braunack-Mayer V, Chen L, Du J, Dunca D, Feitosa MF, Gudmundsdottir V, Guo X, Harris SE, Highland HM, Huang Z, Kang C, Lakka TA, Lefevre C, Luan J, Lyytikäinen LP, Missikpode C, Morrison JL, Palmer ND, Richmond A, Shahisavandi M, Tang J, van der Most PJ, Weiss S, Yu C, Zhu W, Ansari MAY, Anugu P, Aschard H, Ashok K, Attia JR, Bazzano LA, Cade BE, Campbell A, Dimitrov LM, Do A, Faquih T, FinesilverSmith SL, Fisher-Hoch SP, Fretts AM, Gharib SA, Goodarzi MO, Graff M, Gu C, Hanson P, He J, Heikkinen S, Hixson J, Hsu S, Kähönen M, Kho M, Kim H, Komulainen P, Launer LJ, Lemaitre RN, Lifelines Cohort Study, McNeil JJ, McCormick JB, Nolte IM, Raffield LM, Raitakari OT, Ramírez J, Riha RL, Risch M, Risch L, Russ TC, Sarnowski C, Schram MT, Scott RJ, Sofer T, Sun Q, Völker U, Völzke H, Wang Y, van Dijk KW, Wood AC, Young KL, Zhang R, Zhu X, Below JE, Conen D, Cox SR, Fox ER, Franceschini N, Ghanbari M, Grabe HJ, Gudnason V, Hayward C, Holliday EG, Jaquish CE, Lacaze P, Lee S, Lehtimäki T, Liu CT, Morrison AC, North KE, Peyser PA, Province MA, Psaty BM, Rauramaa R, Rosendaal FR, Rotter JI, Snieder H, Wagenknecht LE, Wareham NJ, Giri A, Kelly TN, Munroe PB, Gauderman J, Winkler TW, de Vries PS, Rao DC, Manning AK, Chen H, de Las Fuentes L, Redline S, Meigs JB medRxiv 2026-03-03
A Cross-Language Comparison of Length Perception in Italian-Learning Adults.
Pešková A, Chládková K Lang Speech IF: 1.1 2026-05-28
Population-Level Lambing Interval Patterns and Evaluation of Three Previously Reported Candidate SNPs in Hu and Tan Sheep.
Gou Y, Yin Y, Hao J, Zhao Q, Zhou H, Yuan Z, Yang H, Shalike K, Wang S, Sun W Animals (Basel) IF: 3.2 2026-08-13
Plasma proteomic markers predict risk for bowel resection in inflammatory bowel disease: a retrospective cohort study.
Xu X, Xu C, Zeng N, Sun Q, Xu F, Ma J, Huang X, Zhou M, Sun J, Zhu S, Li P, Zhang S, Lv H, Shi H Int J Surg IF: 9.0 2026-01-12
Circulating monocytes pre-disposed to form atherogenic foam cells are characterised by distinct transcriptional changes in people with HIV.
Hearps AC, Boer J, Brunton-O'Sullivan M, Angelovich TA, Plebanski M, Trevillyan J, Hoy JF, Jaworowski A Atherosclerosis IF: 7.1 2026-03-00
Gallic acid chemoprevention of oral carcinogenesis is associated with HSD11β2 upregulation and immune remodeling.
Upadhaya P, Lamenza FF, Ramalingam R, Nyati KK, Jagadeesha S, Shrestha S, Kehres R, Kazmierowicz N, Dasari S, Masood S, Roth P, Pracha H, Oghumu S Sci Rep IF: 4.9 2026-04-27
ChREBP-mediated regulation of lipid metabolism in liver and brown adipose tissue of long-lived mice.
Hager M, Adam C, Mercier L, Voorhees A, Lee M, Ball L, Yang J, Bartke A, Miller RA, Li X Geroscience IF: 6.0 2026-04-23

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