PBX2 (PBX homeobox 2)

Gene Basic Information

Gene Basic Information

symbol
PBX2
locus group
protein-coding gene
location
6p21.32
gene_family
TALE class homeboxes and pseudogenes
alias symbol
G17|HOX12|PBX2MHC
alias name
None
entrez id
5089
ensembl gene id
ENSG00000204304
ucsc gene id
uc003oav.2
refseq accession
NM_002586
hgnc_id
HGNC:8633
approved reserved
1994-12-13

Chromosome Location

Chromosome Location

6p21.32

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]

OMIM entry for PBX2     Wikipedia entry for PBX2

Gene Sequence

Gene Sequence

Nucleotide sequence of PBX2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MDERLLGPPP PGGGRGGLGL VSGEPGGPGE PPGGGDPGGG
41SGGVPGGRGK QDIGDILQQI MTITDQSLDE AQAKKHALNC
81 HRMKPALFS VLCEIKEKTG LSIRSSQEEE PVDPQLMRLD
121NMLLAEGVAG PEKGGGSAAA AAAAAASGGG VSPDNSIEHS
161D YRSKLAQI RHIYHSELEK YEQACNEFTT HVMNLLREQS
201RTRPVAPKEM ERMVSIIHRK FSAIQMQLKQ STCEAVMILR
241SR FLDARRK RRNFSKQATE VLNEYFYSHL SNPYPSEEAK
281EELAKKCGIT VSQVSNWFGN KRIRYKKNIG KFQEEANIYA
321VKT AVSVTQ GGHSRTSSPT PPSSAGSGGS FNLSGSGDMF
361LGMPGLNGDS YSASQVESLR HSMGPGGYGD NLGGGQMYSP
401REMR ANGSW QEAVTPSSVT SPTEGPGSVH SDTSN
Structure predicted by AlphaFold DB(UniProt: P40425). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of PBX2:           Showing partial SNPs
rs995       rs995       rs995       rs995       rs995       rs995       rs995       rs996       rs996       rs996       rs996       rs996       rs996       rs996       rs997       rs997       rs997      

Gene Expression

Gene Expression

Tissue expression of PBX2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ACCCATATCCTAGTGAGGAG
57
CAAACCAGTTGGAGACCTG
58
GAAACACGCCCTAAACTGC
60
CTGCCAGAAGCATGTTGTC
60
CATCTATGCTGTCAAGACCG
59
TGTCTCCAGATCCTGAGAG
58
AAATGAGGGCAAATGGCAG
59
CAGAGTGAACACTCCCTGG
60
ACCCATATCCTAGTGAGGAG
57
CAAACCAGTTGGAGACCTG
58
ACCCATATCCTAGTGAGGAG
57
CAAACCAGTTGGAGACCTG
58
TAACCCATATCCTAGTGAGGAG
58
AACCAGTTGGAGACCTGAG
59
TAACCCATATCCTAGTGAGGAG
58
AACCAGTTGGAGACCTGAG
59
TAACCCATATCCTAGTGAGGAG
58
AACCAGTTGGAGACCTGAG
59
GGAAACACGCCCTAAACTG
59
AGAAGCATGTTGTCCAAGC
59

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
PBX2
EMX2
Activation
15494461
PBX2
FMO3
Unknown
17786630
PBX2
MEIS1
Unknown
24617557
PBX2
PF4
Activation
12609849
PBX2
UGT2B17
Unknown
12065766
PBX2
VCP
Unknown
19356220

Gene Ontology

Subcellular localization of PBX2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PBX2:

GO ID
Protein
Source DB
GO:0003682
P40425 (UniProtKB)
IEA
GO:0003700
P40425 (UniProtKB)
IEA
GO:0005515
P40425 (UniProtKB)
IPI
GO:0005515
P40425 (UniProtKB)
IPI
GO:0005634
P40425 (UniProtKB)
IDA
GO:0005667
P40425 (UniProtKB)
IEA
GO:0006351
P40425 (UniProtKB)
IEA
GO:0008134
P40425 (UniProtKB)
IPI
GO:0009954
P40425 (UniProtKB)
IEA
GO:0030326
P40425 (UniProtKB)
IEA
GO:0043565
P40425 (UniProtKB)
IEA
GO:0045944
P40425 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating PBX2:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Asthma 0.122367032 1 1 GAD_GWASCAT
Dermatitis, Atopic 0.12 2 1 GWASCAT
Teratocarcinoma 0.00272435 1 0 LHGDN
Diabetes Mellitus, Non-Insulin-Dependent 0.002367032 1 0 GAD
Lupus Erythematosus, Systemic 0.002367032 1 0 GAD
Ulcerative Colitis 0.002367032 1 0 GAD
Spontaneous abortion 0.002367032 1 0 GAD
melanoma 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Congenital Abnormality 0.000271442 1 0 BeFree

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