PBX3-DT (PBX3 divergent transcript)

Gene Basic Information

Gene Basic Information

symbol:
PBX3-DT
locus group:
non-coding RNA
location:
9q33.3
gene_family:
None
alias symbol:
None
alias name:
None
entrez id:
51145
ensembl gene id:
ENSG00000229582
ucsc gene id:
None
refseq accession:
NR_122032
hgnc_id:
HGNC:24638
approved reserved:
2021-07-28

Chromosome Location

Chromosome Location

9q33.3

Gene Summary

Gene Summary

PBX3-DT是一个长链非编码RNA（lncRNA）基因，位于人类基因组19号染色体上，与PBX3基因相邻。PBX3-DT本身不编码蛋白质，但作为调控分子在基因表达中发挥作用。研究表明PBX3-DT可能通过表观遗传调控或作为竞争性内源RNA（ceRNA）影响邻近PBX3基因的表达。PBX3属于PBX（Pre-B-cell leukemia homeobox）基因家族，该家族包含PBX1、PBX2、PBX3和PBX4四个成员，编码同源域转录因子，在胚胎发育、器官形成和细胞分化中起关键作用。PBX家族蛋白通常与HOX蛋白形成复合物调控下游靶基因表达。PBX3-DT的异常表达与多种癌症相关，包括胃癌、肝癌和白血病。在胃癌中PBX3-DT过表达可能通过上调PBX3促进肿瘤细胞增殖和转移，而降低其表达可抑制这些恶性表型。PBX3-DT的突变或表达异常可能破坏其对PBX3的正常调控，进而影响PBX3参与的发育和分化过程。由于PBX3在造血系统和神经系统发育中的重要作用，PBX3-DT的失调可能与这些系统的发育异常或疾病相关。目前对PBX3-DT的具体作用机制仍在研究中，但作为lncRNA它可能通过染色质重塑、转录调控或miRNA海绵等多种方式影响细胞功能。

ChineseEnglish

None

OMIM entry for PBX3-DT     Wikipedia entry for PBX3-DT

Gene Sequence

Gene Sequence

Nucleotide sequence of PBX3-DT:[NCBI]
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Gene Variants

Gene Variants

SNP variants of PBX3-DT:           Showing partial SNPs

Gene Expression

Gene Expression

Tissue expression of PBX3-DT:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of PBX3-DT (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PBX3-DT:

Related microRNA

Related microRNA

microRNAs potentially regulating PBX3-DT:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

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