PGD (phosphogluconate dehydrogenase)

Gene Basic Information

Gene Basic Information

symbol
PGD
locus group
protein-coding gene
location
1p36.22
gene_family
-
alias symbol
-
alias name
None
entrez id
5226
ensembl gene id
ENSG00000142657
ucsc gene id
uc001arc.4
refseq accession
NM_002631
hgnc_id
HGNC:8891
approved reserved
2001-06-22

Chromosome Location

Chromosome Location

1p36.22

Gene Summary

Gene Summary

ChineseEnglish

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

OMIM entry for PGD     Wikipedia entry for PGD

Gene Sequence

Gene Sequence

Nucleotide sequence of PGD:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD
41DFLANEAKGT KVVGAQSLKE MVSKLKKPRR IILLVKAGQA
81 VDDFIEKLV PLLDTGDIII DGGNSEYRDT TRRCRDLKAK
121GILFVGSGVS GGEEGARYGP SLMPGGNKEA WPHIKTIFQG
161I AAKVGTGE PCCDWVGDEG AGHFVKMVHN GIEYGDMQLI
201CEAYHLMKDV LGMAQDEMAQ AFEDWNKTEL DSFLIEITAN
241IL KFQDTDG KHLLPKIRDS AGQKGTGKWT AISALEYGVP
281VTLIGEAVFA RCLSSLKDER IQASKKLKGP QKFQFDGDKK
321SFL EDIRKA LYASKIISYA QGFMLLRQAA TEFGWTLNYG
361GIALMWRGGC IIRSVFLGKI KDAFDRNPEL QNLLLDDFFK
401SAVE NCQDS WRRAVSTGVQ AGIPMPCFTT ALSFYDGYRH
441EMLPASLIQA QRDYFGAHTY ELLAKPGQFI HTNWTGHGGT
481VSSSS YNA
Structure predicted by AlphaFold DB(UniProt: P52209). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of PGD:           Showing partial SNPs
rs505445       rs1049887       rs1134026       rs1140438       rs1140439       rs1140440       rs1140441       rs1140442       rs1140445       rs1140446       rs1300646       rs1307461       rs1889309       rs2229687       rs2229688       rs2236677       rs2236678      

Gene Expression

Gene Expression

Tissue expression of PGD:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CTGATCTGTGAGGCATACCA
59
TCCAATCCTCAAAGGCCTG
60
GCATCATTAGAAGTGTATTCCTAGG
59
GAAGTCGTCCAGTAGGAGG
59
AGCCATAACATAGGTGAGGAG
59
CAGCTTCTCACATATACTTGAGTC
59
ATATAGGGACACCACAAGACG
59
CTTCCTCTCCACCACTGAC
59
ATTCGGAAGGCACTCTACG
60
GATGCCACCATAATTGAGAGTC
59
TTCATCGAGAAATTGAGACGG
59
CTTCCTCTCCACCACTGAC
59
ATGCAGCTGATCTGTGAGG
60
TCCAATCCTCAAAGGCCTG
60
TGCCAAAGATCAGGGACAG
60
AGACAGCTTCTCCAATGAGG
60
TCTTCGGTTCTGCTCTGTC
60
AATTAAGTTCTGGCCCATGAC
59
GACGACTTCTTTAAGTCAGCTG
60
ATAGAAGGAGAGGGCAGTG
58

Gene Ontology

Subcellular localization of PGD (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PGD:

GO ID
Protein
Source DB
GO:0004616
K7EJT3 (UniProtKB)
IEA
GO:0055114
K7EJT3 (UniProtKB)
IEA
GO:0004616
K7ELN9 (UniProtKB)
IEA
GO:0006098
K7ELN9 (UniProtKB)
IEA
GO:0055114
K7ELN9 (UniProtKB)
IEA
GO:0004616
K7EM49 (UniProtKB)
IEA
GO:0006098
K7EM49 (UniProtKB)
IEA
GO:0055114
K7EM49 (UniProtKB)
IEA
GO:0004616
K7EMN2 (UniProtKB)
IEA
GO:0055114
K7EMN2 (UniProtKB)
IEA
GO:0004616
K7EPF6 (UniProtKB)
IEA
GO:0006098
K7EPF6 (UniProtKB)
IEA
GO:0055114
K7EPF6 (UniProtKB)
IEA
GO:0004616
P52209 (UniProtKB)
ISS
GO:0004616
P52209 (UniProtKB)
EXP
GO:0005634
P52209 (UniProtKB)
IDA
GO:0005829
P52209 (UniProtKB)
TAS
GO:0006098
P52209 (UniProtKB)
ISS
GO:0006098
P52209 (UniProtKB)
TAS
GO:0009051
P52209 (UniProtKB)
IDA
GO:0019322
P52209 (UniProtKB)
IEA
GO:0019521
P52209 (UniProtKB)
IEA
GO:0055114
P52209 (UniProtKB)
IDA
GO:0070062
P52209 (UniProtKB)
IDA
GO:0070062
P52209 (UniProtKB)
IDA
GO:0070062
P52209 (UniProtKB)
IDA
GO:0070062
P52209 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating PGD:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Liver carcinoma 0.122367032 2 0 CTD_human_GAD
Hepatitis B, Chronic 0.002367032 1 0 GAD
Liver neoplasms 0.002367032 1 0 GAD
Fragile X Syndrome 0.000814326 3 0 BeFree
Streak gonad 0.000542884 2 0 BeFree
Myotonic Dystrophy 0.000542884 2 0 BeFree
Congenital chromosomal disease 0.000542884 2 0 BeFree
Cooley's anemia 0.000542884 2 0 BeFree
Asthma 0.000542884 2 0 BeFree
Congenital Myotonic Dystrophy 0.000542884 2 0 BeFree

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