PGP (phosphoglycolate phosphatase)

Gene Basic Information

Gene Basic Information

symbol
PGP
locus group
protein-coding gene
location
16p13.3
gene_family
-
alias symbol
-
alias name
None
entrez id
283871
ensembl gene id
ENSG00000184207
ucsc gene id
uc002cpk.2
refseq accession
NM_024118
hgnc_id
HGNC:8909
approved reserved
2001-06-22

Chromosome Location

Chromosome Location

16p13.3

Gene Summary

Gene Summary

PGP（P-糖蛋白，也称为ABCB1或MDR1）是一种重要的膜转运蛋白，属于ATP结合盒（ABC）转运蛋白超家族。它主要分布在肠道、肝脏、肾脏和血脑屏障等组织的上皮细胞膜上，负责将外源性物质（如药物、毒素）从细胞内泵出，从而保护机体免受有害物质的侵害。PGP的生物学功能特点是其依赖ATP水解提供能量，主动转运多种结构不同的底物，包括化疗药物、抗生素和类固醇等。它的主要作用位点是细胞膜，通过外排机制减少细胞内药物积累，影响药物的吸收、分布和排泄。PGP基因突变可能导致功能异常，例如某些突变会降低其转运能力，使药物在细胞内积累，增加毒性或降低疗效；而另一些突变可能导致过度活跃，引起药物抵抗，尤其在癌症化疗中常见多药耐药现象。PGP与多种疾病相关，如炎症性肠病、癫痫和癌症，其高表达常导致化疗失败。如果PGP过表达，会增强药物外排，降低药物疗效，并可能影响其他ABC转运蛋白的功能；反之，若PGP表达降低，药物在体内的浓度可能升高，增加副作用风险。PGP属于ABC转运蛋白家族，该家族成员均具有保守的ATP结合域和跨膜结构域，负责跨膜转运多种分子。这一家族的共性包括利用ATP能量进行底物转运、广泛的底物特异性以及在多种生理和病理过程中起关键作用。PGP的研究对理解药物代谢、耐药机制及开发靶向抑制剂具有重要意义。

OMIM entry for PGP     Wikipedia entry for PGP

Gene Sequence

Gene Sequence

Nucleotide sequence of PGP:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAAAEAGGDD ARCVRLSAER AQALLADVDT LLFDCDGVLW
41RGETAVPGAP EALRALRARG KRLGFITNNS SKTRAAYAEK
81 LRRLGFGGP AGPGASLEVF GTAYCTALYL RQRLAGAPAP
121KAYVLGSPAL AAELEAVGVA SVGVGPEPLQ GEGPGDWLHA
161P LEPDVRAV VVGFDPHFSY MKLTKALRYL QQPGCLLVGT
201NMDNRLPLEN GRFIAGTGCL VRAVEMAAQR QADIIGKPSR
241FI FDCVSQE YGINPERTVM VGDRLDTDIL LGATCGLKTI
281LTLTGVSTLG DVKNNQESDC VSKKKMVPDF YVDSIADLLP
321ALQ G
Structure predicted by AlphaFold DB(UniProt: A6NDG6). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of PGP:           Showing partial SNPs
rs1126       rs11403       rs25849       rs25850       rs25851       rs26848       rs26849       rs26850       rs26851       rs26852       rs26853       rs26854       rs160545       rs160546       rs1610874       rs9930496       rs11546821      

Gene Expression

Gene Expression

Tissue expression of PGP:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TACATGAAGCTCACCAAGG
57
GGTTGATGCCGTATTCCTG
59
TATGTTGACAGCATAGCCGA
59
GCAAGGTTAACAATGAATGCC
58
TATGTTGACAGCATAGCCGA
59
GATGACAGGCATTCCTTGG
59
TATGTTGACAGCATAGCCG
57
GCAAGGTTAACAATGAATGCC
58
TACATGAAGCTCACCAAGG
57
GTTGATGCCGTATTCCTGG
59
TATGTTGACAGCATAGCCG
58
GATGACAGGCATTCCTTGG
59
CTACATGAAGCTCACCAAGG
58
TTGATGCCGTATTCCTGGG
60
ATGTTGACAGCATAGCCGA
60
GATGACAGGCATTCCTTGG
59
ATGTTGACAGCATAGCCGA
59
GCAAGGTTAACAATGAATGCC
58

Gene Ontology

Subcellular localization of PGP (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PGP:

GO ID
Protein
Source DB
GO:0000121
A6NDG6 (UniProtKB)
IEA
GO:0000287
A6NDG6 (UniProtKB)
ISS
GO:0004721
A6NDG6 (UniProtKB)
IBA
GO:0004725
A6NDG6 (UniProtKB)
ISS
GO:0005829
A6NDG6 (UniProtKB)
IBA
GO:0006114
A6NDG6 (UniProtKB)
IDA
GO:0006650
A6NDG6 (UniProtKB)
IDA
GO:0008967
A6NDG6 (UniProtKB)
IDA
GO:0016311
A6NDG6 (UniProtKB)
ISS
GO:0035335
A6NDG6 (UniProtKB)
ISS
GO:0043136
A6NDG6 (UniProtKB)
IDA
GO:0045721
A6NDG6 (UniProtKB)
IMP
GO:0098519
A6NDG6 (UniProtKB)
ISS
GO:0098519
A6NDG6 (UniProtKB)
IBA

Related microRNA

Related microRNA

microRNAs potentially regulating PGP:     

Gene Interactions

Gene Interactions

String
BioGrid
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Polycystic Kidney, Autosomal Dominant 0.001085767 4 0 BeFree
Bipolar Disorder 0.000542884 2 0 BeFree
MAJOR AFFECTIVE DISORDER 2 0.000542884 2 0 BeFree
Myeloid Leukemia 0.000271442 1 0 BeFree
Lymphoid leukemia 0.000271442 1 0 BeFree
Malignant neoplasm of gallbladder 0.000271442 1 0 BeFree
Inflammatory Bowel Diseases 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Polycystic Kidney Diseases 0.000271442 1 0 BeFree

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