PPP1R26-AS1 (PPP1R26 antisense RNA 1)

Gene Basic Information

Gene Basic Information

symbol:
PPP1R26-AS1
locus group:
non-coding RNA
location:
9q34.3
gene_family:
alias symbol:
None
alias name:
None
entrez id:
100506599
ensembl gene id:
ENSG00000225361
ucsc gene id:
None
refseq accession:
NR_038969
hgnc_id:
HGNC:48717
approved reserved:
2013-06-07

Chromosome Location

Chromosome Location

9q34.3

Gene Summary

Gene Summary

PPP1R26-AS1是一个长链非编码RNA（lncRNA）基因，位于人类染色体9q34.3区域，与蛋白磷酸酶1调节亚基26（PPP1R26）基因的反义链重叠。作为非编码RNA，它不编码蛋白质，但通过调控其他基因的表达参与多种生物学过程。研究表明，PPP1R26-AS1在细胞周期调控、增殖和分化中可能发挥作用，尤其与癌症发展相关。它在多种肿瘤中异常表达，例如在肝细胞癌中高表达可能促进肿瘤生长和转移，而在某些其他癌症中低表达可能与不良预后相关。PPP1R26-AS1的突变或表达异常可能通过影响关键信号通路（如Wnt/β-catenin或PI3K/AKT）导致疾病发生。它属于长链非编码RNA基因家族，这类RNA通常通过表观遗传调控、转录干扰或作为竞争性内源RNA（ceRNA）发挥作用。PPP1R26-AS1的过表达可能通过吸附miRNA（如miR-211-5p）解除对下游原癌基因的抑制，促进肿瘤进展；而低表达则可能影响细胞周期相关蛋白（如CDK4/6）的调控。目前对其功能机制的研究仍在深入，尤其在癌症诊断和治疗潜力方面备受关注。

ChineseEnglish

None

OMIM entry for PPP1R26-AS1     Wikipedia entry for PPP1R26-AS1

Gene Sequence

Gene Sequence

Nucleotide sequence of PPP1R26-AS1:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of PPP1R26-AS1:           Showing partial SNPs
rs731267       rs731268       rs881016       rs2384796       rs2590504       rs2777323       rs3748191       rs4841875       rs4841876       rs4841877       rs7019459       rs7033707       rs7044167       rs7849441       rs7873744       rs10718387       rs10745363      

Gene Expression

Gene Expression

Tissue expression of PPP1R26-AS1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TCATTATCTAGAGACAGACAGAGG
59
ATCTCTTGAACCCAGGAGG
58
ACAACCTCACTACAAGCGT
59
CTGGGTGTAGGCTGAACTC
60
GAACTGAAGGCAAGCTACC
59
AAACTTACTCCCGAATGCC
58
GAACTGAAGGCAAGGTGAG
59
TCCCAGAAACATAACTCCGG
60
TATCTAGAGACAGACAGAGGC
58
AAGAATCTCTTGAACCCAGG
57
GAACTGAAGGCAAGCTACC
59
AACTTACTCCCGAATGCCT
59
CAACCTCACTACAAGCGTC
59
CTGGGTGTAGGCTGAACTC
60
GAACTGAAGGCAAGGTGAG
59
CCCAGAAACATAACTCCGG
58
TCTAGAGACAGACAGAGGC
58
ACAAGAATCTCTTGAACCCAG
58
GAACTGAAGGCAAGCTACC
59
TACTCCCGAATGCCTTCAC
60

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of PPP1R26-AS1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PPP1R26-AS1:

Related microRNA

Related microRNA

microRNAs potentially regulating PPP1R26-AS1:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

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Related Publications

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