PPP1R26 (protein phosphatase 1 regulatory subunit 26)

Gene Basic Information

Gene Basic Information

symbol:
PPP1R26
locus group:
protein-coding gene
location:
9q34.3
gene_family:
Protein phosphatase 1 regulatory subunits
alias symbol:
None
alias name:
DRIM/UTP20 interacting protein|1A6…
entrez id:
9858
ensembl gene id:
ENSG00000196422
ucsc gene id:
uc064wyk.1
refseq accession:
NM_014811
hgnc_id:
HGNC:29089
approved reserved:
2004-01-28

Chromosome Location

Chromosome Location

9q34.3

Gene Summary

Gene Summary

PPP1R26（Protein Phosphatase 1 Regulatory Subunit 26）是一种调节蛋白磷酸酶1（PP1）活性的调控亚基，属于PP1调节亚基家族。PP1是一种重要的丝氨酸/苏氨酸蛋白磷酸酶，参与多种细胞过程，如信号转导、细胞周期调控、代谢和基因表达。PPP1R26通过与PP1结合，调控其底物特异性和亚细胞定位，从而影响PP1的生物学功能。PPP1R26在多种组织中表达，但其具体功能尚未完全阐明。研究表明，PPP1R26可能参与细胞增殖、分化和凋亡等过程。突变或异常表达可能影响PP1的活性，进而干扰相关信号通路，导致疾病发生。例如，PPP1R26的异常表达可能与癌症发展相关，因为PP1在肿瘤抑制和细胞周期调控中起关键作用。过表达PPP1R26可能增强PP1的活性，导致某些信号通路过度抑制，影响细胞增殖或代谢；而降低表达可能减弱PP1的活性，导致信号通路过度激活，促进细胞异常增殖或凋亡抵抗。PPP1R26属于PP1调节亚基家族，该家族成员通过结合PP1并指导其作用于特定底物或细胞位置，实现对PP1功能的精细调控。家族成员的共性是含有PP1结合模体，如RVxF、SILK和MyPhoNE等，这些模体介导与PP1的相互作用。PPP1R26的功能研究仍在进行中，未来可能揭示其在疾病中的具体作用机制。

ChineseEnglish

None

OMIM entry for PPP1R26     Wikipedia entry for PPP1R26

Gene Sequence

Gene Sequence

Nucleotide sequence of PPP1R26:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MFLMNASPVV ALQSKWEAFG PPGSCRFPRC FSEADEGVES
41ASVSARVQML ISTLQRDGAA RGTSDERAAQ RGHRAEGCHD
81 ARPAAKPTV HKEPPALAVC GLVADFDPMG EEETTDFGPL
121VLDSDSDDSV DRDIEEAIQE YLKAKSGAAQ PGAGGAQPGA
161A QPSRAAGG GSRCKPEPAH GSAPTALCPP KLVPGSGGGP
201GSQVGSSKDQ GSASPVSVSS DDSFEQSIRA EIEQFLNEKR
241QH ETQKCDG SVEKKPDTNE NSAKSLLKSH QEPPTKVVHR
281QGLLGVQKEF AFRKPPRLAK MNVQPRSLRS KVTTTQENEG
321STK PATPCR PSEAAQNKGG IKRSASAARR GKRVMSAAQA
361SEASDSSSDD GIEEAIQLYQ LQKTRKEADG DLPQRVQLRE
401ERAP DPPAH STSSATKSAL PETHRKTPSK KKLVATKTMD
441PGPGGLDTDH APKLLKETKA PPPASPASRS EFVERSSCRA
481DTSAE LMCA EAILDISKTI LPAPVEGSDG SLSASPLFYS
521PNVPSRSDGD SSSVDSDDSI EQEIRTFLAL KAQSGSLLAR
561GESCPQ AAQ GPLLPPGLNS QTGGHKTPLS KTPDPLLGCK
601RKRRGGGHVR PSTPKKMQEV VKDGSQDADH SQGRAEPGHE
641RRDLPIQ GK ASEALGGEGT ARGPGDTRMS QGQGKTDEAR
681RLDEKESSED KSSSLDSDED LDTAIKDLLR SKRKLKKRCR
721EPRAACRK K VRFSTAQTHF LEQLGGLRRD WKDRGPPVLK
761SCLSKSKRDS GEGPGKKPPS VFGSTAERMR QEGAASQDAA
801LAFRVRRPA SASASEGNPF PRESQGPAPS PGSLSDDSSS
841VDSNDSIELE IRKFLAEKAK ESVSSSEVQA EGPTALGTGG
881PARPEVLCRK EPAPPPGVC TRSQRARGVP HLAEGLRGTE
921SAGAQGTAGL FSQGGKGLPA APARGDPVPP RSTSGGVSAK
961GLSVSRRNVY V HKDQSPRG AEPAAKSAFG QLPSCATAGT
1001EAGGARGTFH MGCGSPSFLT PSPGAERDAG AQADRTPPWS
1041DFAHQSRLPS PW VLRSEGR DAVWRGGVGS ERDKGSEGPA
1081RGLPSLPLAG FSPLLSTQLF HFGKGVSWGG RQAGLFSPHL
1121GLPLQGPSFS AFR EAQAGP SPVFGSPHLL AKKDGGPWPT
1161RKAQAGLSLH DRRSSGSEES ILDLRYRRRV NRDDQEQDAL
1201GSDASDFSDT STED SGGSS VVKV
结构预测来自 AlphaFold DB（UniProt: Q5T8A7），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of PPP1R26:           Showing partial SNPs
rs914644       rs1412512       rs1808998       rs1975518       rs2004074       rs2078266       rs2100011       rs2254812       rs2254813       rs2590503       rs2770820       rs2777324       rs3748192       rs3748195       rs3748197       rs3748198       rs3762066      

Gene Expression

Gene Expression

Tissue expression of PPP1R26:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CGAAAGCTCAAGAAGAGGTG
59
TGAACCTGACCTTCTTCCT
58
AACTTTGGAGGATGTGAAGC
59
CTGGAGAAGCGTTCATGAG
58
AACTTTGGAGGATGTGAAGC
59
CTGGAGAAGCGTTCATGAG
58
AACTTTGGAGGATGTGAAGC
59
CTGGAGAAGCGTTCATGAG
58
AACTTTGGAGGATGTGAAGC
59
CTGGAGAAGCGTTCATGAG
58
CAGAATTTCAAGAGCTTGTCG
58
AGGATGACTAGAAACCCAGG
59
AGGAGGAAACTACAGACTTTGG
60
TCCACGGAATCATCACTGTC
60
ACTTTGGAGGATGTGAAGC
58
CTGGAGAAGCGTTCATGAG
58
ACTTTGGAGGATGTGAAGC
58
CTGGAGAAGCGTTCATGAG
58
ACTTTGGAGGATGTGAAGC
58
CTGGAGAAGCGTTCATGAG
58

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of PPP1R26 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PPP1R26:

GO ID
Protein
Source DB
GO:0004864
Q5T8A7 (UniProtKB)
IEA
GO:0005515
Q5T8A7 (UniProtKB)
IPI
GO:0005515
Q5T8A7 (UniProtKB)
IPI
GO:0005515
Q5T8A7 (UniProtKB)
IPI
GO:0005654
Q5T8A7 (UniProtKB)
IDA
GO:0005730
Q5T8A7 (UniProtKB)
IEA
GO:0010923
Q5T8A7 (UniProtKB)
IDA
GO:0019902
Q5T8A7 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating PPP1R26:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

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Whole transcriptome sequencing identifies tumor-specific mutations in human oral squamous cell carcinoma.
Zhang Qu, Zhang Jun, Jin Hong, Sheng Sitong BMC Med Genomics IF: 2.848 2014-06-25
The origin of the RB1 imprint.
Kanber Deniz, Buiting Karin, Roos Christian, Gromoll Jörg, Kaya Sabine, Horsthemke Bernhard, Lohmann Dietmar PLoS One IF: 2.6 2014-08-05

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