PRKCD基因详情-基因数据库-基因云馆

PRKCD (protein kinase C delta)

symbol:: PRKCD
locus group:: protein-coding gene
location:: 3p21.1
gene_family:: C2 domain containing protein kinases
alias symbol:: None
alias name:: None
entrez id:: 5580
ensembl gene id:: ENSG00000163932
ucsc gene id:: uc003dgm.4
refseq accession:: NM_001316327
hgnc_id:: HGNC:9399
approved reserved:: 1991-08-06

3p21.1

PRKCD（蛋白激酶C delta型）属于蛋白激酶C（PKC）家族，这是一个丝氨酸/苏氨酸激酶家族，参与多种细胞信号传导过程。PKC家族成员通常通过磷脂酰肌醇信号通路被激活，并在细胞增殖、分化、凋亡和迁移等过程中发挥关键作用。PRKCD作为PKC家族的一员，主要分布在多种组织中，尤其在免疫细胞和神经系统中表达较高。它的生物学功能包括调控细胞凋亡、炎症反应、氧化应激反应以及免疫细胞的活化。PRKCD通过磷酸化下游靶蛋白来传递信号，影响细胞的命运和功能。PRKCD的突变或异常表达与多种疾病相关，包括癌症、自身免疫性疾病和神经退行性疾病。例如，PRKCD的过度激活可能导致细胞凋亡异常，促进肿瘤发展；而在某些自身免疫疾病中，PRKCD的活性增强可能加剧炎症反应。相反，PRKCD表达降低可能导致免疫细胞功能缺陷，增加感染风险。PRKCD还参与调控其他基因的表达或活性，例如通过影响NF-κB等转录因子的活性来调节炎症相关基因的表达。在基因家族方面，PKC家族根据其结构和激活机制分为三类：经典PKC（cPKC，如PKCα、PKCβ）、新型PKC（nPKC，如PKCδ、PKCε）和非典型PKC（aPKC，如PKCζ）。PRKCD属于新型PKC，这类成员不依赖钙离子但需要二酰基甘油（DAG）激活。PKC家族的共性包括参与细胞信号传导、依赖第二信使激活以及通过磷酸化底物蛋白调控细胞功能。PRKCD的过表达可能增强细胞对凋亡信号的敏感性，而表达降低则可能削弱免疫应答或导致细胞存活异常。这些特性使PRKCD成为多种疾病治疗的潜在靶点。

中文English

蛋白激酶C（PKC）是可以通过钙和第二信使甘油二酯被激活丝氨酸和苏氨酸特异性蛋白激酶家族。 PKC家族成员磷酸化多种蛋白靶和已知参与不同的细胞信号传导途径。 PKC家族成员还作为主要受体佛波醇酯，一类促癌物。在PKC家族的每个成员都有一个特定的表达谱，被认为在细胞中发挥不同作用。由该基因编码的蛋白质是蛋白激酶C家族成员之一。无论是在人类和小鼠的研究表明，该激酶是参与B细胞信号传导和生长，细胞凋亡，和各种细胞类型的分化的调节。编码相同蛋白质可变剪接转录物变体已观察到。 [由RefSeq的，2008年7月提供]

OMIM数据库中对PRKCD基因的介绍 Wikipedia数据库中对PRKCD基因的介绍

PRKCD基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MAPFLRIAFN SYELGSLQAE DEANQPFCAV KMKEALSTER
41GKTLVQKKPT MYPEWKSTFD AHIYEGRVIQ IVLMRAAEEP
81
VSEVTVGVS VLAERCKKNN GKAEFWLDLQ PQAKVLMSVQ
121YFLEDVDCKQ SMRSEDEAKF PTMNRRGAIK QAKIHYIKNH
161E
FIATFFGQ PTFCSVCKDF VWGLNKQGYK CRQCNAAIHK
201KCIDKIIGRC TGTAANSRDT IFQKERFNID MPHRFKVHNY
241MS
PTFCDHC GSLLWGLVKQ GLKCEDCGMN VHHKCREKVA
281NLCGINQKLL AEALNQVTQR ASRRSDSASS EPVGIYQGFE
321KKT
GVAGED MQDNSGTYGK IWEGSSKCNI NNFIFHKVLG
361KGSFGKVLLG ELKGRGEYFA IKALKKDVVL IDDDVECTMV
401EKRV
LTLAA ENPFLTHLIC TFQTKDHLFF VMEFLNGGDL
441MYHIQDKGRF ELYRATFYAA EIMCGLQFLH SKGIIYRDLK
481LDNVL
LDRD GHIKIADFGM CKENIFGESR ASTFCGTPDY
521IAPEILQGLK YTFSVDWWSF GVLLYEMLIG QSPFHGDDED
561ELFESI
RVD TPHYPRWITK ESKDILEKLF EREPTKRLGV
601TGNIKIHPFF KTINWTLLEK RRLEPPFRPK VKSPRDYSNF
641DQEFLNE
KA RLSYSDKNLI DSMDQSAFAG FSFVNPKFEH
681LLED

结构预测来自 AlphaFold DB（UniProt: Q05655），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

PRKCD基因的碱基突变：仅显示部分snp

rs750170 rs750527 rs750528 rs900495 rs1056998 rs1075865 rs1483184 rs1483185 rs1483186 rs1483187 rs1872035 rs2035451 rs2128709 rs2230493 rs2230494 rs2230497 rs2242305

PRKCD基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

CCTTCTTCAAGACCATAAACTGG

TGGGTGACTTCACTTTGGG

TGATTCTTCTGCCTCAGCC

TAGGAGTTGAAGGCGATGC

GAACAATGGCAAGGCTGAG

GTTTGCAATCCACGTCCTC

CCTTCTTCAAGACCATAAACTGG

TGGGTGACTTCACTTTGGG

GAACAATGGCAAGGCTGAG

CTGTTTGCAATCCACGTCC

TGCCGTGAAGATGAAGGAG

TCCACTCAGGATACATGGTC

AAGAACAATGGCAAGGCTG

CAGACATCAACACCTTGGC

TCCACAAGAAATGCATCGAC

CTTTCTGGAATATAGTGTCCCG

GAACAATGGCAAGGCTGAG

ACAGACATCAACACCTTGG

AAGAACAATGGCAAGGCTG

GTTTGCAATCCACGTCCTC

尚未收录相关数据

PRKCD基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

PRKCD基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005737

C9J9P1 (UniProtKB)

IDA

GO:0005737

C9K0E3 (UniProtKB)

IDA

GO:0035556

C9K0E3 (UniProtKB)

IEA

GO:0046872

C9K0E3 (UniProtKB)

IEA

GO:0002223

Q05655 (UniProtKB)

TAS

GO:0004672

Q05655 (UniProtKB)

IDA

GO:0004674

Q05655 (UniProtKB)

IDA

GO:0004674

Q05655 (UniProtKB)

EXP

GO:0004674

Q05655 (UniProtKB)

EXP

GO:0004674

Q05655 (UniProtKB)

IDA

GO:0004674

Q05655 (UniProtKB)

IDA

GO:0004674

Q05655 (UniProtKB)

TAS

GO:0004697

Q05655 (UniProtKB)

ISS

GO:0004697

Q05655 (UniProtKB)

TAS

GO:0004697

Q05655 (UniProtKB)

TAS

GO:0004699

Q05655 (UniProtKB)

TAS

GO:0004699

Q05655 (UniProtKB)

EXP

GO:0004715

Q05655 (UniProtKB)

IEA

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005515

Q05655 (UniProtKB)

IPI

GO:0005524

Q05655 (UniProtKB)

IEA

GO:0005634

Q05655 (UniProtKB)

IDA

GO:0005634

Q05655 (UniProtKB)

IDA

GO:0005634

Q05655 (UniProtKB)

IDA

GO:0005634

Q05655 (UniProtKB)

IDA

GO:0005654

Q05655 (UniProtKB)

TAS

GO:0005737

Q05655 (UniProtKB)

IDA

GO:0005737

Q05655 (UniProtKB)

IDA

GO:0005737

Q05655 (UniProtKB)

IDA

GO:0005737

Q05655 (UniProtKB)

IDA

GO:0005783

Q05655 (UniProtKB)

IDA

GO:0005783

Q05655 (UniProtKB)

IDA

GO:0005829

Q05655 (UniProtKB)

IDA

GO:0005829

Q05655 (UniProtKB)

IDA

GO:0005829

Q05655 (UniProtKB)

TAS

GO:0005829

Q05655 (UniProtKB)

TAS

GO:0005829

Q05655 (UniProtKB)

TAS

GO:0005829

Q05655 (UniProtKB)

TAS

GO:0005829

Q05655 (UniProtKB)

TAS

GO:0005829

Q05655 (UniProtKB)

TAS

GO:0005829

Q05655 (UniProtKB)

TAS

GO:0005829

Q05655 (UniProtKB)

TAS

GO:0005829

Q05655 (UniProtKB)

TAS

GO:0005829

Q05655 (UniProtKB)

TAS

GO:0005829

Q05655 (UniProtKB)

TAS

GO:0005886

Q05655 (UniProtKB)

IDA

GO:0005886

Q05655 (UniProtKB)

IDA

GO:0005886

Q05655 (UniProtKB)

TAS

GO:0005886

Q05655 (UniProtKB)

TAS

GO:0005886

Q05655 (UniProtKB)

TAS

GO:0005911

Q05655 (UniProtKB)

IEA

GO:0006468

Q05655 (UniProtKB)

IDA

GO:0006468

Q05655 (UniProtKB)

IDA

GO:0006915

Q05655 (UniProtKB)

IDA

GO:0006921

Q05655 (UniProtKB)

TAS

GO:0007049

Q05655 (UniProtKB)

IEA

GO:0007165

Q05655 (UniProtKB)

TAS

GO:0007202

Q05655 (UniProtKB)

TAS

GO:0008047

Q05655 (UniProtKB)

IDA

GO:0008631

Q05655 (UniProtKB)

TAS

GO:0010469

Q05655 (UniProtKB)

TAS

GO:0016064

Q05655 (UniProtKB)

IEA

GO:0016363

Q05655 (UniProtKB)

IEA

GO:0016572

Q05655 (UniProtKB)

IDA

GO:0018105

Q05655 (UniProtKB)

IDA

GO:0018107

Q05655 (UniProtKB)

IDA

GO:0018108

Q05655 (UniProtKB)

IEA

GO:0019899

Q05655 (UniProtKB)

IPI

GO:0019899

Q05655 (UniProtKB)

IDA

GO:0019899

Q05655 (UniProtKB)

IPI

GO:0019900

Q05655 (UniProtKB)

IPI

GO:0019901

Q05655 (UniProtKB)

IPI

GO:0023021

Q05655 (UniProtKB)

IMP

GO:0030168

Q05655 (UniProtKB)

TAS

GO:0030837

Q05655 (UniProtKB)

ISS

GO:0032079

Q05655 (UniProtKB)

IMP

GO:0032091

Q05655 (UniProtKB)

TAS

GO:0032147

Q05655 (UniProtKB)

IDA

GO:0032613

Q05655 (UniProtKB)

IEA

GO:0032615

Q05655 (UniProtKB)

IEA

GO:0032930

Q05655 (UniProtKB)

IMP

GO:0032956

Q05655 (UniProtKB)

IMP

GO:0034351

Q05655 (UniProtKB)

IMP

GO:0035307

Q05655 (UniProtKB)

IMP

GO:0038096

Q05655 (UniProtKB)

TAS

GO:0042100

Q05655 (UniProtKB)

IEA

GO:0042119

Q05655 (UniProtKB)

IDA

GO:0042307

Q05655 (UniProtKB)

IMP

GO:0042742

Q05655 (UniProtKB)

ISS

GO:0043407

Q05655 (UniProtKB)

IMP

GO:0043488

Q05655 (UniProtKB)

TAS

GO:0043560

Q05655 (UniProtKB)

ISS

GO:0046627

Q05655 (UniProtKB)

ISS

GO:0046627

Q05655 (UniProtKB)

TAS

GO:0046872

Q05655 (UniProtKB)

IEA

GO:0048471

Q05655 (UniProtKB)

IEA

GO:0050728

Q05655 (UniProtKB)

GO:0050732

Q05655 (UniProtKB)

ISS

GO:0050821

Q05655 (UniProtKB)

NAS

GO:0051490

Q05655 (UniProtKB)

ISS

GO:0060326

Q05655 (UniProtKB)

IMP

GO:0060333

Q05655 (UniProtKB)

TAS

GO:0070062

Q05655 (UniProtKB)

IDA

GO:0070062

Q05655 (UniProtKB)

IDA

GO:0070301

Q05655 (UniProtKB)

IDA

GO:0071447

Q05655 (UniProtKB)

IDA

GO:0090331

Q05655 (UniProtKB)

ISS

GO:0090398

Q05655 (UniProtKB)

IMP

GO:1900163

Q05655 (UniProtKB)

IMP

GO:1904385

Q05655 (UniProtKB)

IDA

GO:2000304

Q05655 (UniProtKB)

IMP

GO:2000753

Q05655 (UniProtKB)

IMP

GO:2000755

Q05655 (UniProtKB)

IMP

GO:2001022

Q05655 (UniProtKB)

IMP

GO:2001235

Q05655 (UniProtKB)

IEA

可能调控 PRKCD基因的相关microRNA：

hsa-miR-484 hsa-miR-615-3p

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
4530 Tight junction [PATH:hsa04530]
4664 Fc epsilon RI signaling pathway [PATH:hsa04664]
4666 Fc gamma R-mediated phagocytosis [PATH:hsa04666]
4062 Chemokine signaling pathway [PATH:hsa04062]
4912 GnRH signaling pathway [PATH:hsa04912]
4915 Estrogen signaling pathway [PATH:hsa04915]
4270 Vascular smooth muscle contraction [PATH:hsa04270]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750]
4930 Type II diabetes mellitus [PATH:hsa04930]

名称
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
C-type lectin receptors (CLRs)
Ca-dependent events
Calmodulin induced events
CaM pathway
CLEC7A (Dectin-1) signaling
Cytokine Signaling in Immune system
DAG and IP3 signaling
DAP12 interactions
DAP12 signaling
Downstream signal transduction
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
Effects of PIP2 hydrolysis
EGFR interacts with phospholipase C-gamma
Fcgamma receptor (FCGR) dependent phagocytosis
G alpha (q) signalling events
G alpha (z) signalling events
G-protein mediated events
Gastrin-CREB signalling pathway via PKC and MAPK
Gene Expression
GPCR downstream signaling
Hemostasis
HuR stabilizes mRNA
Immune System
Innate Immune System
Interferon gamma signaling
Interferon Signaling
NGF signalling via TRKA from the plasma membrane
Opioid Signalling
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Phospholipase C-mediated cascade: FGFR1
Platelet activation, signaling and aggregation
PLC beta mediated events
PLC-gamma1 signalling
PLCG1 events in ERBB2 signaling
Programmed Cell Death
Regulation of mRNA stability by proteins that bind AU-rich elements
Role of phospholipids in phagocytosis
Signaling by EGFR
Signaling by ERBB2
Signaling by FGFR
Signaling by FGFR1
Signaling by FGFR2
Signaling by FGFR3
Signaling by FGFR4
Signaling by GPCR
Signaling by PDGF
Signaling by VEGF
Signalling by NGF
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Diabetes Mellitus, Experimental	0.2	2	0	CTD_human_RGD
Hypertensive disease	0.2	3	0	CTD_human_RGD
AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III	0.12	0	3	CLINVAR
Neurotoxicity Syndromes	0.12	1	0	CTD_human
Common Variable Immunodeficiency	0.12	0	0	ORPHANET
Parkinsonian Disorders	0.12	1	0	CTD_human
SYSTEMIC LUPUS ERYTHEMATOSUS 16	0.12	0	0	ORPHANET
Seizures	0.12	1	0	CTD_human
Autoimmune Lymphoproliferative Syndrome	0.12	0	0	ORPHANET
Intestinal Neoplasms	0.12	1	0	CTD_human

Dong Z, Wang L, Lang Y, Zhang R, Wang Y, Zhao C, Chen Q, Zheng Y Front Cardiovasc Med IF: 3.0 None

Sevoflurane activates ATF4/NSUN7/PRKCD axis to induce neurotoxicity and cognitive impairment by promoting neuron mitochondrial fission.

Fu Q, Chen L, Zeng X, Lan C, Wang G, Li S, Lv T, Chen H Chem Biol Interact IF: 5.2 2026-06-01

SUMOylation-Driven Subtype Heterogeneity and Prognostic Biomarkers in Renal Cell Carcinoma.

Zhang X, Li Z, Lin R, Yang S, Sun X, Chen S Curr Issues Mol Biol IF: 4.1 2026-07-23

A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator.

Zaalberg A, Lacoste A, Minnee E, Mayayo-Peralta I, Schuurman K, Gregoricchio S, van Schaik TA, Hoekman L, Li D, Corey E, Janssen H, Lieftink C, Prekovic S, Proost N, van de Ven M, Zander S, Altelaar M, Nelson PS, Beijersbergen RL, Zwart W, Bergman AM Oncogene IF: 9.1 2026-07-28

PRKCD Orchestrates Sevoflurane-Induced Cognitive Dysfunction in Aged Rats by Regulating PINK1/PRKN Mitophagy Pathway.

Yu Y, Zhang W, Zhao Y, Zhang Y, Li P, He Z J Cell Mol Med IF: 4.499 2026-08-00

CASP1 as a key autophagy-related gene in atherosclerosis: Identification by bioinformatics analysis and experimental validation.

Gao H, Guo Y, Wang L, Shen Y, Liu W PLoS One IF: 2.6 None

Multi-Omics and Machine Learning Analyses Reveal PIK3CG, PRKCD, and TRIM22 as Potential Markers of Poor Prognosis and Immune Activation in Glioblastoma.

Han MH, Noh YK, Kim H, Kim KS, Kim DH, Jung US, Lee KS, Kwon MJ, Chae SW, Min KW J Korean Med Sci IF: 3.2 2026-04-27

Predicting Pain Using a Data-Driven Agent-Based Model of the Bilateral Central Amygdala.

Paul BK, Kwiatkowski M, Zhantibiyeva F, Singh S, Nguyen C, Singari SVD, Perumal CD, Anandan I, Adke AP, Sadler KE, Carrasquillo Y, Neilan RM, Kolber BJ bioRxiv 2026-04-28

Clinical Response to Baricitinib in Monogenic Lupus: Real-World Evidence from a Case Series of Seven Patients.

Al-Mayouf SM, AlAsmari A, Al-Saleem A Mediterr J Rheumatol IF: 2.1 2026-03-00

Research on the correlation and potential mechanism of PKCδ expression with efficacy and prognosis in diffuse large B-cell lymphoma.

Zhao X, Li S, Zhu L, Wu M, Hu X, Liang X, Wang S, Maihemaiti A, Adili A, Wen S Front Oncol IF: 3.4 None

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PRKCD (protein kinase C delta)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

基因相关评论

联系地址

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