PRY2 (PTPN13 like Y-linked 2)

Gene Basic Information

Gene Basic Information

symbol
PRY2
locus group
protein-coding gene
location
Yq11.223
gene_family
-
alias symbol
PTPN13LY2
alias name
None
entrez id
442862
ensembl gene id
ENSG00000169807
ucsc gene id
uc004fuy.1
refseq accession
NM_001002758
hgnc_id
HGNC:21504
approved reserved
2004-08-25

Chromosome Location

Chromosome Location

Yq11.223

Gene Summary

Gene Summary

ChineseEnglish

This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. It encodes a protein which has a low degree of similarity to protein tyrosine phosphatase, non-receptor type 13. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more centromeric copy. [provided by RefSeq, Jul 2008]

OMIM entry for PRY2     Wikipedia entry for PRY2

Gene Sequence

Gene Sequence

Nucleotide sequence of PRY2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE
41LSLNRGLEAR RKKDLKDSFL WRYGKVGCIS LPLREMTAWI
81 NPPQISEIF QGYHQRVHGA DALSLQTNSL RSRLSSQCLG
121QSFLLRTLER GRGFRALGDI CGHVHEED
Structure predicted by AlphaFold DB(UniProt: O14603). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Expression

Gene Expression

Tissue expression of PRY2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TGGCTTTCTACTTTCCTGGA
59
TATTGCATCCCTGGCAGTC
60
GAACTTTCCTTGAACAGAGGT
58
AACCTTCCCATATCTCCAGAG
59
ACTTTCCTTGAACAGAGGTC
58
CCAACCTTCCCATATCTCC
57
TGGCTTTCTACTTTCCTGGAG
60
TATTGCATCCCTGGCAGTC
60
GGCTTTCTACTTTCCTGGAG
58
TATTGCATCCCTGGCAGTC
60
AACTTTCCTTGAACAGAGGTC
58
CAACCTTCCCATATCTCCAG
58

Related microRNA

Related microRNA

microRNAs potentially regulating PRY2:     

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Male infertility 0.000271442 1 0 BeFree

Related Publications

Related Publications

Expression pattern of the Y-linked PRY gene suggests a function in apoptosis but not in spermatogenesis.
Stouffs Katrien, Lissens Willy, Verheyen Greta, Van Landuyt Lisbet, Goossens Annieta, Tournaye Herman, Van Steirteghem André, Liebaers Inge Mol Hum Reprod IF: 4.2 2016-04-23
Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins.
Choudhary Vineet, Schneiter Roger Proc Natl Acad Sci U S A IF: 9.5 2012-12-31
Screening of genes involved in isooctane tolerance in Saccharomyces cerevisiae by using mRNA differential display.
Miura S, Zou W, Ueda M, Tanaka A Appl Environ Microbiol IF: 4.2 2001-01-04
Characterization of the genomic organization, localization and expression of four PRY genes (PRY1, PRY2, PRY3 and PRY4).
Stouffs K, Lissens W, Van Landuyt L, Tournaye H, Van Steirteghem A, Liebaers I Mol Hum Reprod IF: 4.2 2001-10-18
Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein.
Darwiche Rabih, Kelleher Alan, Hudspeth Elissa M, Schneiter Roger, Asojo Oluwatoyin A Sci Rep IF: 4.9 0000-00-00

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