PRYP3 (PTPN13 like Y-linked pseudogene 3)

Gene Basic Information

Gene Basic Information

symbol:
PRYP3
locus group:
pseudogene
location:
Yq11.223
gene_family:
alias symbol:
None
alias name:
None
entrez id:
442865
ensembl gene id:
ENSG00000169763
ucsc gene id:
None
refseq accession:
NG_087976
hgnc_id:
HGNC:34020
approved reserved:
2008-03-14

Chromosome Location

Chromosome Location

Yq11.223

Gene Summary

Gene Summary

PRYP3（也称为PRY domain-containing protein 3）属于PRY/SPRY基因家族，该家族成员通常含有PRY（Poxvirus and Zinc finger）或SPRY（SPla and the RYanodine Receptor）结构域，这些结构域参与蛋白质-蛋白质相互作用，并在免疫调节、细胞信号传导和生殖系统功能中发挥重要作用。PRYP3主要在睾丸中高表达，表明其可能在精子发生或男性生殖功能中起关键作用。PRYP3的生物学功能尚未完全阐明，但基于其家族特性，推测它可能参与精子细胞的分化、成熟或受精过程。PRY/SPRY家族蛋白通常与免疫应答相关，例如调节炎症反应或自身免疫疾病，但PRYP3的具体作用机制仍需进一步研究。若PRYP3发生突变，可能影响男性生育能力，导致少精症或无精症等生殖障碍。过表达PRYP3可能干扰正常的精子发生过程，而表达降低则可能导致精子发育异常或活力下降。目前尚未发现PRYP3与特定疾病的直接关联，但由于其在睾丸特异性表达，可能与男性不育症相关。PRY/SPRY基因家族的共性在于其结构域介导的蛋白质相互作用，参与多种细胞过程，包括免疫调控、细胞凋亡和生殖系统功能。该家族的其他成员如TRIM5α和SSB-1在抗病毒防御和DNA修复中具有重要作用，而PRYP3的功能可能与其家族成员有部分重叠或独特之处。研究PRYP3有助于深入理解男性生殖生物学及潜在的不育症治疗靶点。

OMIM entry for PRYP3     Wikipedia entry for PRYP3

Gene Sequence

Gene Sequence

Nucleotide sequence of PRYP3:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE
41LSLNRGLEAR RKKDLKDSFL WRYGKVGCIS LPLREMTAWI
81 NPPQISEIF QGYHQRVHGA DALSLQTNSL RSRLSSQCLG
121QSFLLRTLER GRGFRALGDI CGHVHEED
结构预测来自 AlphaFold DB（UniProt: O14603），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of PRYP3:           Showing partial SNPs

Gene Expression

Gene Expression

Tissue expression of PRYP3:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GAACTTTCCTTGAACAGAGGT
58
AACCTTCCCATATCTCCAGAG
59
GAACTTTCCTTGAACAGAGGT
58
AACCTTCCCATATCTCCAGAG
59
ACTTTCCTTGAACAGAGGTC
58
CCAACCTTCCCATATCTCC
57
ACTTTCCTTGAACAGAGGTC
58
CCAACCTTCCCATATCTCC
57
AACTTTCCTTGAACAGAGGTC
58
CAACCTTCCCATATCTCCAG
58
AACTTTCCTTGAACAGAGGTC
58
CAACCTTCCCATATCTCCAG
58

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of PRYP3 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PRYP3:

Related microRNA

Related microRNA

microRNAs potentially regulating PRYP3:     

Gene Interactions

Gene Interactions

Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Prostate carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Male infertility 0.000271442 1 0 BeFree

Related Publications

Related Publications

No related publications

Related Services

Related Services

Comments

Comments

Loading comments...

Log in to post comments Log In Sign Up

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2