PRYP4 (PTPN13 like Y-linked pseudogene 4)

Gene Basic Information

Gene Basic Information

symbol:
PRYP4
locus group:
pseudogene
location:
Yq11.23
gene_family:
alias symbol:
None
alias name:
None
entrez id:
442866
ensembl gene id:
ENSG00000172283
ucsc gene id:
None
refseq accession:
NG_004755
hgnc_id:
HGNC:34021
approved reserved:
2008-03-14

Chromosome Location

Chromosome Location

Yq11.23

Gene Summary

Gene Summary

PRYP4（也称为PRY domain-containing protein 4）属于PRY/SPRY基因家族，该家族成员通常含有PRY（Poxvirus and Zinc finger）和SPRY（SPla and the RYanodine receptor）结构域，这些结构域参与蛋白质-蛋白质相互作用，并在免疫调节、信号传导和细胞凋亡等过程中发挥重要作用。PRYP4的具体功能尚未完全阐明，但研究表明它可能在精子发生和男性生殖系统中发挥作用，特别是在精子形成和成熟过程中。PRYP4的表达主要局限于睾丸组织，暗示其在生殖生物学中的潜在重要性。PRYP4或其表达产物的突变可能导致男性不育或精子功能异常，但目前相关研究较少，具体机制仍需进一步探索。PRYP4的过表达或降低表达对机体的影响尚不明确，但可能干扰精子发生相关信号通路，从而影响生殖功能。PRYP4所在的PRY/SPRY基因家族成员通常参与免疫应答和细胞间相互作用，部分家族蛋白与自身免疫疾病或癌症相关，但PRYP4在这些疾病中的具体作用尚未明确。由于研究有限，PRYP4的详细生物学功能、突变效应及疾病关联仍需更多实验验证。

OMIM entry for PRYP4     Wikipedia entry for PRYP4

Gene Sequence

Gene Sequence

Nucleotide sequence of PRYP4:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE
41LSLNRGLEAR RKKDLKDSFL WRYGKVGCIS LPLREMTAWI
81 NPPQISEIF QGYHQRVHGA DALSLQTNSL RSRLSSQCLG
121QSFLLRTLER GRGFRALGDI CGHVHEED
结构预测来自 AlphaFold DB（UniProt: O14603），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of PRYP4:           Showing partial SNPs

Gene Expression

Gene Expression

Tissue expression of PRYP4:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GAACTTTCCTTGAACAGAGGT
58
AACCTTCCCATATCTCCAGAG
59
ACTTTCCTTGAACAGAGGTC
58
CCAACCTTCCCATATCTCC
57
AACTTTCCTTGAACAGAGGTC
58
CAACCTTCCCATATCTCCAG
58

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of PRYP4 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PRYP4:

Related microRNA

Related microRNA

microRNAs potentially regulating PRYP4:     

Gene Interactions

Gene Interactions

Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Male infertility 0.000271442 1 0 BeFree

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