PAEP (progestagen associated endometrial protein)

Gene Basic Information

Gene Basic Information

symbol
PAEP
locus group
protein-coding gene
location
9q34.3
gene_family
Lipocalins
alias symbol
PEP|PP14|GdA|GdS|GdF|PAEG|GD|MGC138509|MGC142288
alias name
glycodelin-A|glycodelin-S|glycodel…
entrez id
5047
ensembl gene id
ENSG00000122133
ucsc gene id
uc004cgd.2
refseq accession
NM_001018049
hgnc_id
HGNC:8573
approved reserved
1991-07-25

Chromosome Location

Chromosome Location

9q34.3

Gene Summary

Gene Summary

ChineseEnglish

This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. A number of alternatively spliced transcript variants have been observed at this locus, but the full-length nature of only two, each encoding the same protein, has been determined. [provided by RefSeq, Jul 2008]

OMIM entry for PAEP     Wikipedia entry for PAEP

Gene Sequence

Gene Sequence

Nucleotide sequence of PAEP:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MLCLLLTLGV ALVCGVPAMD IPQTKQDLEL PKLAGTWHSM
41AMATNNISLM ATLKAPLRVH ITSLLPTPED NLEIVLHRWE
81 NNSCVEKKV LGEKTENPKK FKINYTVANE ATLLDTDYDN
121FLFLCLQDTT TPIQSMMCQY LARVLVEDDE IMQGFIRAFR
161P LPRHLWYL LDLKQMEEPC RF
Structure predicted by AlphaFold DB(UniProt: P09466). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of PAEP:           Showing partial SNPs
rs697448       rs705661       rs783487       rs783488       rs783772       rs783773       rs783774       rs783776       rs2070909       rs2770826       rs2780283       rs3119934       rs3748202       rs3748203       rs3748204       rs3748205       rs3748206      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TCAAGATCAACTATACGGTGG
57
CCTGTAGGCAGAGAAACAG
58
TCAAGATCAACTATACGGTGG
57
CCTGTAGGCAGAGAAACAG
58
ACAACATCTCCCTCATGGC
59
TTGTTCTCCCATCTGTGCA
59
ATTCATCAGGGCTTTCAGG
58
CGAGACTCCATCTAGAAACG
58
TTCAAGATCAACTGCAAGGC
59
GACTCTGGCTGTGGAAGAG
60
TCAAGATCAACTATACGGTGG
57
CCTGTAGGCAGAGAAACAG
58
AGATCAACTCCAGAGTCCTG
59
CAAGTACCATAGGTGCCTG
58
TCAAGATCAACTATACGGTGG
57
CCTGTAGGCAGAGAAACAG
58
TCAAGATCAACTATACGGTGG
57
CCTGTAGGCAGAGAAACAG
58
TCAAGATCAACTATACGGTGG
57
CCTGTAGGCAGAGAAACAG
58

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
GATA3
PAEP
Activation
19483726

Gene Ontology

Subcellular localization of PAEP (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PAEP:

GO ID
Protein
Source DB
GO:0006810
A6XNE0 (UniProtKB)
IEA
GO:0006810
F2Z349 (UniProtKB)
IEA
GO:0006810
H0Y4U4 (UniProtKB)
IEA
GO:0006810
H0Y6A4 (UniProtKB)
IEA
GO:0005515
P09466 (UniProtKB)
IPI
GO:0005576
P09466 (UniProtKB)
IEA
GO:0006810
P09466 (UniProtKB)
IEA
GO:0006915
P09466 (UniProtKB)
IDA
GO:0007275
P09466 (UniProtKB)
TAS
GO:0032725
P09466 (UniProtKB)
IDA
GO:0036094
P09466 (UniProtKB)
IEA
GO:2000667
P09466 (UniProtKB)
IDA
GO:2000778
P09466 (UniProtKB)
IDA
GO:0006810
Q5T6T6 (UniProtKB)
IEA

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Mammary Neoplasms 0.122995792 3 0 BeFree_CTD_human_LHGDN
Spontaneous abortion 0.12 1 0 CTD_human
Hepatitis C 0.030672932 113 4 BeFree
Hepatitis C, Chronic 0.027687071 102 2 BeFree
Hepatitis B 0.009771907 36 0 BeFree
Hepatitis B, Chronic 0.007057489 26 0 BeFree
HIV Infections 0.004885954 18 0 BeFree
Endometriosis 0.003810118 5 0 BeFree_LHGDN
Fibroid Tumor 0.002995792 2 0 BeFree_LHGDN
Malignant neoplasm of breast 0.002985861 11 0 BeFree

Related Publications

Related Publications

Establishment of a Novel Human Endometrial Organoid.
Yoneda T, Tamura I, Yoshimura A, Ito M, Shiroshita A, Fujimura T, Shirafuta Y, Sato S, Sugino N Reprod Med Biol IF: 4.3 None
Comparative transcriptomic analysis of endometrial tissue associated with uterine fibroids and endometrial polyps.
Korczyńska L, Dąbrowska M, Kulecka M, Hennig EE, Ali M, Bałabas A, Czarnowski P, Olcha P, Łoziński T, Laganà AS, Ostrowski J, Ciebiera M, Zeber-Lubecka N Sci Rep IF: 4.9 2026-06-08
Hybrid transcriptome sequencing uncovers widespread shifts in transcript usage between mid-lactation and dry-off in goats.
Cardoso TF, Wang M, Noce A, Luigi-Sierra M, Martínez A, Delgado-Bermejo JV, Salama AAK, Such FX, Jordana J, Amills M J Dairy Sci IF: 4.7 2026-07-27
A non-invasive, patient-derived organoid platform from uterine lavage fluid for modeling endometrial implantation and disease.
Qiu H, Fan Z, Liu D, Deng L, Wang X, Yang Y, Yang T, Tian F, Hao J, Zhang Q, Xu B, Fu J, Ni H, Li Y, Su H, Xiao F, Sun Y, Chen J, Duan Z, Zhao J, Li H, Li Y Stem Cell Res Ther IF: 4.211 2026-07-14
Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis.
Sousa MJ, Vriendt S, Liu L, Ruiz TFR, Vankelecom H, Amorim CA Adv Sci (Weinh) IF: 9.034 2026-07-09
Learning Work Function via Implicit Reasoning on Electrostatic Potential Landscapes.
Wan H, Wu Y, Su T, Pan D Adv Sci (Weinh) IF: 9.034 2026-08-18
Spatial transcriptomics and histopathological analyses reveal potential biomarkers and immune features linked to recurrence in head and neck cancer.
Weeramange CE, Chen Y, Nguyen KM, Zhang X, Hartel G, Causer A, Mulay O, Pavithra P, Lam PY, Gonzalez Cruz J, Vasani S, Kenny L, Taheri T, Breik O, Nguyen Q, Punyadeera C Front Immunol IF: 7.0 None
TMB-related immune gene PAEP influences clear cell renal cell carcinoma progression and prognosis.
Yang J, Wu G, Wu Q, Hu X, Peng Z, Zhang D, He S Eur J Med Res IF: 4.8 2026-01-17

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