RARA-AS1Gene Detail-Gene Database-Genelibs

RARA-AS1 (RARA antisense RNA 1)

symbol

RARA-AS1

locus group

non-coding RNA

location

17q21.2

gene_family

-

alias symbol

-

alias name

None

entrez id

101929693

ensembl gene id

ENSG00000265666

ucsc gene id

-

refseq accession

NR_110861

hgnc_id

HGNC:49577

approved reserved

2014-01-17

17q21.2

RARA-AS1是一个长链非编码RNA（lncRNA）基因，位于人类17号染色体上，与视黄酸受体α（RARA）基因相邻，属于RARA基因的反义转录本。它通过调控RARA基因的表达参与多种生物学过程，包括细胞分化、增殖和凋亡。RARA-AS1的主要作用位点在细胞核内，通过与染色质修饰复合物或转录因子相互作用来调节邻近基因的表达。该基因的突变可能导致其调控功能异常，进而影响RARA信号通路，与急性早幼粒细胞白血病（APL）等疾病的发生有关。RARA-AS1过表达可能增强RARA的抑制作用，导致细胞分化受阻，而降低表达则可能解除对RARA的调控，促进细胞异常增殖。RARA-AS1属于非编码RNA基因家族，这类基因通常不编码蛋白质，但通过调控其他基因的表达在表观遗传和转录水平发挥重要作用。研究表明，RARA-AS1的异常表达与肿瘤发生发展密切相关，尤其在血液系统恶性肿瘤中可能作为潜在生物标志物或治疗靶点。

OMIM entry for RARA-AS1 Wikipedia entry for RARA-AS1

Nucleotide sequence of RARA-AS1:[NCBI]

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SNP variants of RARA-AS1: Showing partial SNPs

rs2920395 rs9303285 rs9303286 rs59406133 rs74763542 rs74814495 rs79524876 rs79807495 rs112359597 rs112509970 rs113062113 rs117074300 rs138835393 rs144099603 rs144985665 rs148691170 rs149514124

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

TATCCTCACAGCAACTCCA

58

ACATAGCCTTGCTGAGACC

60

TTTATCCTCACAGCAACTCCA

60

ATAGCCTTGCTGAGACCTG

59

TTATCCTCACAGCAACTCCA

59

CATAGCCTTGCTGAGACCT

59

Discovery and Validation of Immune Infiltration-related Genes for the Prognosis of Osteoporosis.

Xu H, Xu F, Chen L, Wu R, Ge H, Li A Iran J Allergy Asthma Immunol IF: 1.5 2025-03-10

RAD51-AS1 inhibits the migration and invasion of prostate cancer cells by up-regulating RARA to activate ZYX transcription.

Chen Z, Wang X, Mao L, Guan H, Chen M Discov Oncol 2025-10-24

The lncRNA expression profile signature of leukemia stem cells is altered upon PI3K/mTOR inhibition: an in vitro and in silico study.

Kayabasi C, Gunduz C Nucleosides Nucleotides Nucleic Acids IF: 1.0 2024-00-00

LncRNA RARA-AS1 could serve as a novel prognostic biomarker in pan-cancer and promote proliferation and migration in glioblastoma.

Huang Y, Deng S, Jiang Q, Shi J Sci Rep IF: 4.9 2023-00-13

Analysis of bulk RNA-seq data from sepsis patients reveals sepsis-associated lncRNAs and targeted cell death-related genes contributing to immune microenvironment regulation.

Cheng Y, Xu L, Wang J, Cao X, Chen D, Zhang P, Yang L, Qin L Front Immunol IF: 7.0 2023-00-00

Analysis of mRNA‑lncRNA and mRNA‑lncRNA-pathway co‑expression networks based on WGCNA in developing pediatric sepsis.

Zhang X, Cui Y, Ding X, Liu S, Han B, Duan X, Zhang H, Sun T Bioengineered 2021-00-00

Transcriptional alterations of protein coding and noncoding RNAs in triple negative breast cancer in response to DNA methyltransferases inhibition.

Elango R, Vishnubalaji R, Shaath H, Alajez NM Cancer Cell Int IF: 2.740 2021-09-26

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