RARBGene Detail-Gene Database-Genelibs

RARB (retinoic acid receptor beta)

symbol

RARB

locus group

protein-coding gene

location

3p24.2

gene_family

Nuclear hormone receptors

alias symbol

HAP|NR1B2|RRB2|RARbeta|RAR-beta

alias name

None

entrez id

5915

ensembl gene id

ENSG00000077092

ucsc gene id

uc003cdh.4

refseq accession

NM_000965|NM_016152

hgnc_id

HGNC:9865

approved reserved

1989-05-16

3p24.2

ChineseEnglish

This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]

OMIM entry for RARB Wikipedia entry for RARB

Nucleotide sequence of RARB:[NCBI]

Loading Gene Browser...

Protein Sequence

1MTTSGHACPV PAVNGHMTHY PATPYPLLFP PVIGGLSLPP
41LHGLHGHPPP SGCSTPSPAT IETQSTSSEE LVPSPPSPLP
81
PPRVYKPCF VCQDKSSGYH YGVSACEGCK GFFRRSIQKN
121MIYTCHRDKN CVINKVTRNR CQYCRLQKCF EVGMSKESVR
161N
DRNKKKKE TSKQECTESY EMTAELDDLT EKIRKAHQET
201FPSLCQLGKY TTNSSADHRV RLDLGLWDKF SELATKCIIK
241IV
EFAKRLP GFTGLTIADQ ITLLKAACLD ILILRICTRY
281TPEQDTMTFS DGLTLNRTQM HNAGFGPLTD LVFTFANQLL
321PLE
MDDTET GLLSAICLIC GDRQDLEEPT KVDKLQEPLL
361EALKIYIRKR RPSKPHMFPK ILMKITDLRS ISAKGAERVI
401TLKM
EIPGS MPPLIQEMLE NSEGHEPLTP SSSGNTAEHS
441PSISPSSVEN SGVSQSPLVQ

Structure predicted by AlphaFold DB(UniProt: P10826). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

SNP variants of RARB: Showing partial SNPs

rs1159899 rs1384901 rs1483844 rs2291296 rs2306623 rs2306624 rs6765860 rs6781619 rs6784498 rs6800388 rs7627850 rs9817799 rs9832598 rs11129198 rs11401651 rs11421888 rs11917383

Tissue expression of RARB: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

TTTGCTAAACGTCTGCCTG

59

TTCTAAGAATCAGGATGTCCAGG

60

GTCCAAAGAATAATTCCAGTGC

58

AATAATGCACTTGGTGGCC

59

TTTGCTAAACGTCTGCCTG

59

TTCTAAGAATCAGGATGTCCAGG

60

CCAAAGAATCTGTCAGGAATGAC

60

CAGCTGTCATTTCATAGCTCTC

59

TTTGCTAAACGTCTGCCTG

59

TTCTAAGAATCAGGATGTCCAGG

60

CCTGTGAGGGATGTAAGGG

59

CATTCCTGACAGATTCTTTGGAC

59

GTCATCGGAGGACTTTCCC

60

CTGTGTTTCAATTGTTGCCG

59

CAGTGCTAAAGGTGCAGAG

58

AGCATTTCTTGAATGAGAGGTG

59

CTTAATCTGTGGAGACCGC

58

TTTAGTGCTTCCAGCAATGG

59

TCAAAGCATGCTTCAGTGG

58

ATTGATTGAGCAGTGTGCC

58

Transcription Factors

Target Gene

Interaction Type

PubMed References

FOXD3

RARB

Activation

23058321

HDAC1

RARB

Repression

14731134

JUN

RARB

Activation

9377582

PPARG

RARB

Activation

12839938

RARA

RARB

Activation

10629091

RARB

ADH5

Unknown

1996113

RARB

Activation

12767074

RARB

THBD

Unknown

11036068

RARG

RARB

Unknown

1310259

SNW1

RARB

Unknown

19934264

Subcellular localization of RARB (and its protein):

[UniProt] [GenomeNet]

plasma membrane
cytoplasm
extracellular
golgi
vesicle
cytoskeleton
endoplasmic reticulum
nucleus
endosome
lysosome
mitochondrion

Gene Ontology (GO) terms for RARB:

GO ID

Protein

Source DB

GO:0003707

D6RBI3 (UniProtKB)

IEA

GO:0003708

D6RBI3 (UniProtKB)

IEA

GO:0005634

D6RBI3 (UniProtKB)

IEA

GO:0006351

D6RBI3 (UniProtKB)

IEA

GO:0006355

D6RBI3 (UniProtKB)

IEA

GO:0008270

D6RBI3 (UniProtKB)

IEA

GO:0043401

D6RBI3 (UniProtKB)

IEA

GO:0043565

D6RBI3 (UniProtKB)

IEA

GO:0048384

D6RBI3 (UniProtKB)

IEA

GO:0000122

P10826 (UniProtKB)

IEA

GO:0000977

P10826 (UniProtKB)

IEA

GO:0001657

P10826 (UniProtKB)

IEA

GO:0002068

P10826 (UniProtKB)

IEA

GO:0003148

P10826 (UniProtKB)

IEA

GO:0003406

P10826 (UniProtKB)

IEA

GO:0003417

P10826 (UniProtKB)

IEA

GO:0003677

P10826 (UniProtKB)

TAS

GO:0003707

P10826 (UniProtKB)

IEA

GO:0003708

P10826 (UniProtKB)

IEA

GO:0005515

P10826 (UniProtKB)

IPI

GO:0005515

P10826 (UniProtKB)

IPI

GO:0005515

P10826 (UniProtKB)

IPI

GO:0005515

P10826 (UniProtKB)

IPI

GO:0005634

P10826 (UniProtKB)

IDA

GO:0005654

P10826 (UniProtKB)

IDA

GO:0005654

P10826 (UniProtKB)

TAS

GO:0005654

P10826 (UniProtKB)

TAS

GO:0005654

P10826 (UniProtKB)

TAS

GO:0005737

P10826 (UniProtKB)

IEA

GO:0006367

P10826 (UniProtKB)

TAS

GO:0007165

P10826 (UniProtKB)

TAS

GO:0008144

P10826 (UniProtKB)

IEA

GO:0008270

P10826 (UniProtKB)

IEA

GO:0008284

P10826 (UniProtKB)

IEA

GO:0008285

P10826 (UniProtKB)

IEA

GO:0021756

P10826 (UniProtKB)

IEA

GO:0031641

P10826 (UniProtKB)

IEA

GO:0032331

P10826 (UniProtKB)

IEA

GO:0032403

P10826 (UniProtKB)

IEA

GO:0035116

P10826 (UniProtKB)

IEA

GO:0035264

P10826 (UniProtKB)

IEA

GO:0043065

P10826 (UniProtKB)

IEA

GO:0043066

P10826 (UniProtKB)

IEA

GO:0043401

P10826 (UniProtKB)

IEA

GO:0045666

P10826 (UniProtKB)

IEA

GO:0045944

P10826 (UniProtKB)

IEA

GO:0046965

P10826 (UniProtKB)

IEA

GO:0048048

P10826 (UniProtKB)

IEA

GO:0048384

P10826 (UniProtKB)

IEA

GO:0048566

P10826 (UniProtKB)

IMP

GO:0055012

P10826 (UniProtKB)

IEA

microRNAs potentially regulating RARB:

hsa-miR-16-2*

String

BioGrid

IntAct

mentha

MINT

Reactome

Loading…

Interacting Gene	Interaction	Source/Score

KEGG
Reactomepathway

Name
5200 Pathways in cancer [PATH:hsa05200]
5222 Small cell lung cancer [PATH:hsa05222]
5223 Non-small cell lung cancer [PATH:hsa05223]

Name
Gene Expression
Generic Transcription Pathway
Nuclear Receptor transcription pathway
Signaling by Retinoic Acid

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
MICROPHTHALMIA, SYNDROMIC 12	0.24	1	3	CLINVAR_UNIPROT
Squamous cell carcinoma	0.13361182	15	0	BeFree_CTD_human_LHGDN
Mammary Neoplasms	0.131711727	8	0	BeFree_CTD_human_LHGDN
Lung Neoplasms	0.131168843	6	0	BeFree_CTD_human_LHGDN
Head and Neck Neoplasms	0.12272435	2	0	CTD_human_LHGDN
Adenocarcinoma	0.120271442	2	0	BeFree_CTD_human
Stomach Neoplasms	0.120271442	2	0	BeFree_CTD_human
Uterine Cervical Neoplasm	0.12	1	0	CTD_human
Sciatic Neuropathy	0.12	1	0	CTD_human
Endometriosis	0.12	1	0	CTD_human

The dual role of retinoic acid signaling in clear cell renal cell carcinoma and wilms tumor: A tale of two entities.

Qiang SHI, Zehua LI, Huilin FU, Haifeng SHI, Jie GU Biochim Biophys Acta Rev Cancer IF: 11.2 2026-07-23

The methylation of LHX2, RAPGEFL1, RARB and RYR2 has prognostic significance in head and neck squamous cell carcinoma patients.

Skalski M, Kowal-Wiśniewska E, Jaskiewicz-Rajewicz K, Kiwerska K, Bartochowska A, Ustaszewski A, Górecki T, Majchrzak-Celińska A, Wierzbicka M, Jarmuż-Szymczak M, Paluszczak J J Appl Genet IF: 2.1 2026-03-02

Characterization of Ocular Developmental Disorders in the Israeli Population: Genotype-Phenotype Correlations and Novel Candidate Genes.

Rabinovich Y, Vardizer Y, Pincovich S, Wolowelsky M, Kulyamzin S, Ehrenberg M, Zayit-Soudry S, Man Peles I, Leibu R, Goldenberg-Cohen N, Ben-Yosef T Biomolecules 2026-08-21

Molecular and Clinical Analyses of 111 Patients with Bilateral Anterior-Segment Dysgenesis/Aniridia and Microphthalmia/Anophthalmia.

Nishina S, Anzai H, Yoshida T, Koyanagi Y, Kamada S, Kato K, Torii K, Hikoya A, Kondo M, Sotozono C, Matsubara K, Fukami M Ophthalmol Sci IF: 5.0 2026-10-00

Circulating DNA-Markers of High Risk for Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease.

Ponomaryova AA, Boyarko VV, Wang L, Huang Z, Korobeynikova AA, Gervas PA, Kapitanova DV, Bukreeva EB, Pancova OV, Zarubin AA, Perelmuter VM, Cherdyntseva NV, Denisov EV Bull Exp Biol Med IF: 0.7 2026-03-00

Molecular Links Between Smoking, COPD, and Lung Cancer: A DNA Methylation Perspective.

Forigua CB, Bermúdez LG, Cañas Arboleda A, Ariza RR, Roldán MT, Morales MT, González Cubides DM, Rojas A Cancers (Basel) 2026-04-17

Unraveling the molecular basis of clinical heterogeneity in Hirschsprung disease through gene expression analysis.

Isa MM, Syukri M, Muchlisin ZA, Gunadi, Syahputra DA, Yusriadi T, Muzakkir Y, Kamarlis RK, Effendy Z, Setyadi A, Maghfirah S, Rinanda T Pediatr Surg Int IF: 1.8 2026-05-08

Clinical features of syndromic microphthalmia in two novel RARB variants.

Koyanagi Y, Morikawa-Anzai H, Yoshida T, Tominaga M, Abe Y, Kosaki R, Matsubara K, Fukami M, Nishina S Hum Genome Var 2026-04-06

Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular mechanisms underlying clutch length differences in goose ovaries.

Wang H, Liu Y, Jiang K, Yin J, Cong K, Miao X, Yang W, Zhang Y, Liu S Poult Sci IF: 4.5 2026-06-00

Whole-genome resequencing with multidimensional annotation revealed pathogenic networks in sirenomelia.

Zhu Z, Hao W, Wan Z, Ma T, Xu Y, Wang Y, Gu W Ital J Pediatr IF: 3.5 2026-08-14

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RARB (retinoic acid receptor beta)

Gene Basic Information

Gene Basic Information

Chromosome Location

Chromosome Location

Gene Summary

Gene Summary

Gene Sequence

Gene Sequence

Encoded Protein

Encoded Protein

Gene Variants

Gene Variants

Gene Expression

Gene Expression

Gene Primers

Gene Primers

Transcription Factors

Transcription Factors

Gene Ontology

Related microRNA

Related microRNA

Gene Interactions

Gene Interactions

Gene Pathways

Gene Pathways

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