RBMY1D (RNA binding motif protein Y-linked family 1 member D)

symbol:
RBMY1D
locus group:
protein-coding gene
location:
Yq11.223
gene_family:
RNA binding motif containing
alias symbol:
None
alias name:
None
entrez id:
378949
ensembl gene id:
ENSG00000244395
ucsc gene id:
uc004fuu.3
refseq accession:
NM_001006120
hgnc_id:
HGNC:23915
approved reserved:
2004-12-10
Yq11.223
ChineseEnglish

This gene encodes a protein with an N-terminal RNA-binding motif and four C-terminal SRGY (serine, arginine, glycine, tyrosine) boxes. Multiple copies of this gene occur in the AZFb azoospermia factor region of the Y chromosome, and the encoded protein is thought to participate in spermatogenesis. Most copies at this locus are pseudogenes; six highly similar copies containing full-length ORFs are considered functional. Four functional copies lie within inverted repeat IR2, and two functional copies are found in palindrome P3, along with two copies of PTPN13-like, Y-linked.

Nucleotide sequence of RBMY1D:[NCBI]
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Protein Sequence
1MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI
41KDRTSKSRGF AFITFENPAD AKNAAKDMNG KSLHGKAIKV
81 EQAKKPSFQ SGGRRRPPAS SRNRSPSGSL RSARGSRGGT
121RGWLPSQEGH LDDGGYTPDL KMSYSRGLIP VKRGPSSRSG
161G PPPKKSAP SAVARSNSWM GSQGPMSQRR ENYGVPPRRA
201TISSWRNDRM STRHDGYATN DGNHPSCQET RDYAPPSRGY
241AY RDNGHSN RDEHSSRGYR NHRSSRETRD YAPPSRGHAY
281RDYGHSRRDE SYSRGYRNRR SSRETREYAP PSRGHGYRDY
321GHS RRHESY SRGYRNHPSS RETRDYAPPH RDYAYRDYGH
361SSWDEHSSRG YSYHDGYGEA LGRDHSEHLS GSSYRDALQR
401YGTS HGAPP ARGPRMSYGG STCHAYSNTR DRYGRSWESY
441SSCGDFHYCD REHVCRKDQR NPPSLGRVLP DPREACGSSS
481YVASI VDGG ESRSEKGDSS RY
结构预测来自 AlphaFold DB(UniProt: P0C7P1),颜色表示 pLDDT 置信度(深蓝高、黄橙低)。
SNP variants of RBMY1D:           Showing partial SNPs

Tissue expression of RBMY1D:    [UniProt]

Gene expression across tissues
Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GCGACAATATCTTCCTGGAG
58
ACTTGGATGATTTCCATCGT
57
TCTAGAGGCCATGCATACC
58
ACTTCGACGATTTCTGTATCCT
59
TCTAGAGGCCATGCATACC
58
ACTTCGACGATTTCTGTATCC
58
      No data available

Subcellular localization of RBMY1D (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RBMY1D:

GO ID
Protein
Source DB
GO:0000166
P0C7P1 (UniProtKB)
IEA
GO:0003723
P0C7P1 (UniProtKB)
IEA
GO:0005634
P0C7P1 (UniProtKB)
IEA
GO:0006397
P0C7P1 (UniProtKB)
IEA
GO:0008380
P0C7P1 (UniProtKB)
IEA

microRNAs potentially regulating RBMY1D:     

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Interacting Gene Interaction Source/Score
Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

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