RBMY1F (RNA binding motif protein Y-linked family 1 member F)

symbol:
RBMY1F
locus group:
protein-coding gene
location:
Yq11.223
gene_family:
RNA binding motif containing
alias symbol:
MGC33094
alias name:
None
entrez id:
159163
ensembl gene id:
ENSG00000169800
ucsc gene id:
uc004fva.4
refseq accession:
NM_152585
hgnc_id:
HGNC:23974
approved reserved:
2004-12-10
Yq11.223
ChineseEnglish

This gene encodes a protein with an N-terminal RNA-binding motif and four C-terminal SRGY (serine, arginine, glycine, tyrosine) boxes. Multiple copies of this gene are found in the AZFb azoospermia factor region of the Y chromosome, and the encoded protein is thought to be involved in spermatogenesis. Most copies at this locus are pseudogenes, while six highly similar copies with full-length ORFs are considered functional. Four functional copies occur within inverted repeat IR2, and two functional copies are found in palindrome P3, along with two Y-linked PTPN13-like copies. [Provided by RefSeq, Jul 2008]

Nucleotide sequence of RBMY1F:[NCBI]
Loading Gene Browser...
Protein Sequence
1MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI
41KDRTSKSRGF AFITFENPAD AKNAAKDMNG TSLHGKAIKV
81 EQAKKPSFQ SGGRRRPPAS SRNRSPSGSL RSARGSSGGT
121RGWLPSHEGH LDDGGYTPDL KMSYSRGLIP VKRGPSSRSG
161G PPPKKSAP SAVARSNSWM GSQGPMSQRR ENYGVPPRRA
201TISSWRNDRM STRHDGYATN DGNHPSCQET RDYAPPSRGY
241AY RDNGHSN RDEHSSRGYR NHRSSRETRD YAPPSRGHAY
281RDYGHSRRDE SYSRGYRNHR SSRETREYAP PSRGHGYRDY
321GHS RRHESY SRGYRNHPSS RETRDYAPPH RDYAYRDYGH
361SSWDEHSSRG YSYHDGYGEA LGRDHSEHLS GSSYRDALQR
401YGTS HGAPP ARGPRMSYGG STCHAYSNTR DRYGRSWESY
441SSCGDFHYCD REHVCRKDQR NPPSLGRVLP DPREAYGSSS
481YVASI VDGG ESRSEKGDSS RY
结构预测来自 AlphaFold DB(UniProt: Q15415),颜色表示 pLDDT 置信度(深蓝高、黄橙低)。
SNP variants of RBMY1F:           Showing partial SNPs
rs776497943       rs777213028       rs774683798       rs774299427       rs773388034       rs771544975       rs768990171       rs770705402       rs766742668       rs767729783       rs762034965       rs764987485       rs759236905       rs761253238       rs754676380       rs755263141       rs754292663      

Tissue expression of RBMY1F:    [UniProt]

Gene expression across tissues
Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ATGGAACGATGATGGTGGA
59
CACTTCTTGAAGATGGACCTC
59
GGATATAGTTATCATGATGGCTACG
59
GTGCATCTCTATAAGAACTTCCAC
59
GAGATCTGCAAGAGGAAGC
58
GTGTATCCACCATCATCCAG
58
GCGACAATATCTTCCTGGA
57
ACTTGGATGATTTCCATCGT
57
TGAGATCTGCAAGAGGAAGC
60
TGTATCCACCATCATCCAGG
59
CAACTAACGATGGAAATCATCC
57
TATCACGGTATGCATAGCCT
58
AATGGAACGATGATGGTGG
58
ACTTCTTGAAGATGGACCTC
57
CTAGAGGCCATGGATACCG
59
CGTAGCCATCATGATAACTATATCC
59
GCGACAATATCTTCCTGGAG
58
ACTTGGATGATTTCCATCGT
57
TCTGAGATCTGCAAGAGGA
57
TATCCACCATCATCCAGGT
57
      No data available

Subcellular localization of RBMY1F (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RBMY1F:

GO ID
Protein
Source DB
GO:0000166
Q15415 (UniProtKB)
IEA
GO:0003723
Q15415 (UniProtKB)
NAS
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005515
Q15415 (UniProtKB)
IPI
GO:0005575
Q15415 (UniProtKB)
ND
GO:0005634
Q15415 (UniProtKB)
IEA
GO:0006397
Q15415 (UniProtKB)
IEA
GO:0007283
Q15415 (UniProtKB)
NAS
GO:0008380
Q15415 (UniProtKB)
IEA

microRNAs potentially regulating RBMY1F:     

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score
Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

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