RNF41 (ring finger protein 41)

基因基本信息

基因基本信息

symbol:
RNF41
locus group:
protein-coding gene
location:
12q13.3
gene_family:
Ring finger proteins
alias symbol:
SBBI03|NRDP1
alias name:
None
entrez id:
10193
ensembl gene id:
ENSG00000181852
ucsc gene id:
uc001skf.3
refseq accession:
NM_005785
hgnc_id:
HGNC:18401
approved reserved:
2003-05-21

基因染色体位置

基因染色体位置

12q13.3

基因简述

基因简述

RNF41（Ring Finger Protein 41）是一种E3泛素连接酶，属于RING（Really Interesting New Gene）指蛋白家族成员，该家族的特征是含有一个保守的RING结构域，能够介导蛋白质的泛素化修饰，从而调控蛋白质的稳定性、定位或功能。RNF41通过泛素化修饰靶蛋白，参与多种细胞过程，包括信号转导、内吞作用、免疫调节和神经发育等。其主要作用位点包括细胞膜、内体和细胞质，通过与多种蛋白质相互作用发挥功能。RNF41的突变可能导致其泛素连接酶活性异常，影响下游信号通路，例如在神经退行性疾病中，RNF41的功能失调可能与异常蛋白聚集有关。此外，RNF41与某些癌症（如乳腺癌和白血病）的发生发展相关，其表达水平的变化可能影响肿瘤细胞的增殖和迁移。RNF41还参与调节细胞因子信号，如抑制促炎细胞因子受体（如IL-6受体和EGFR）的稳定性，从而调控炎症反应。当RNF41过表达时，可能导致其靶蛋白的过度降解，破坏正常的信号传导，例如抑制生长因子受体的信号，影响细胞生长和存活。相反，RNF41表达降低可能导致靶蛋白积累，如促炎受体或致癌蛋白的稳定性增加，加剧炎症或肿瘤发生。RNF41所在的RING指蛋白家族成员普遍具有E3泛素连接酶活性，通过泛素-蛋白酶体系统调控蛋白质稳态，参与细胞周期、DNA修复和免疫应答等重要生物学过程。

中文English

该基因编码的E3泛素连接酶。所编码的蛋白在1型细胞因子受体的信号，通过控制JAK2相关的细胞因子受体的退化和胞外域脱落之间的平衡的作用。选择性剪接结果在多个抄本变形。 [由RefSeq的，2011年6月提供]

OMIM数据库中对RNF41基因的介绍     Wikipedia数据库中对RNF41基因的介绍

基因序列

基因序列

RNF41基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN
41ACITQWFSQQ QTCPVDRSVV TVAHLRPVPR IMRNMLSKLQ
81 IACDNAVFG CSAVVRLDNL MSHLSDCEHN PKRPVTCEQG
121CGLEMPKDEL PNHNCIKHLR SVVQQQQTRI AELEKTSAEH
161K HQLAEQKR DIQLLKAYMR AIRSVNPNLQ NLEETIEYNE
201ILEWVNSLQP ARVTRWGGMI STPDAVLQAV IKRSLVESGC
241PA SIVNELI ENAHERSWPQ GLATLETRQM NRRYYENYVA
281KRIPGKQAVV VMACENQHMG DDMVQEPGLV MIFAHGVEEI
结构预测来自 AlphaFold DB（UniProt: Q9H4P4），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

RNF41基因的碱基突变：           仅显示部分snp
rs1274495       rs2629449       rs2629450       rs5798368       rs11171779       rs11548554       rs12820113       rs12821012       rs59420211       rs66864435       rs71081333       rs73340401       rs74092035       rs74454414       rs75309020       rs75842277       rs78687047      

基因表达

基因表达

RNF41基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CAGTACAGGTCATTTCTCTGC
59
GTAATCGTGAGCTTCTCCTC
58
TGCTAAAGGCATACATGCG
59
TTCACCCACTCTAGGATCTC
58
TGATGTAACCCGTTTCCAG
58
CAATGAGGTGCCTGTACTG
58
TCAATAGGTCATTTCTCTGCCA
60
ATGAGGTGCCTGGTAATCG
60
TTGCAGTGGAGTCTTGGAG
60
ATGAGGTGCCTGGTAATCG
60
GCTAAAGGCATACATGCGT
59
GTAAGCTACTCTAGGATCTCGT
58
TACAACGAGATCCTAGAGTGG
59
ATCAGGAGTCGAGATCATCC
59
CAACACTTGGAAGGACCTG
58
ATAAGATCTTCGTCAACATCCC
58
TGATGTAACCCGTTTCCAG
58
CAATGAGGTGCCTGTACTG
58
TGATGTAACCCGTTTCCAG
58
CAATGAGGTGCCTGTACTG
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

RNF41基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

RNF41基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004842
F8VNZ6 (UniProtKB)
IEA
GO:0008270
F8VNZ6 (UniProtKB)
IEA
GO:0016567
F8VNZ6 (UniProtKB)
IEA
GO:0016881
F8VNZ6 (UniProtKB)
IEA
GO:0031386
F8VNZ6 (UniProtKB)
IEA
GO:0004842
F8VSB6 (UniProtKB)
IEA
GO:0008270
F8VSB6 (UniProtKB)
IEA
GO:0016567
F8VSB6 (UniProtKB)
IEA
GO:0016881
F8VSB6 (UniProtKB)
IEA
GO:0031386
F8VSB6 (UniProtKB)
IEA
GO:0004842
F8VSP7 (UniProtKB)
IEA
GO:0008270
F8VSP7 (UniProtKB)
IEA
GO:0016567
F8VSP7 (UniProtKB)
IEA
GO:0016881
F8VSP7 (UniProtKB)
IEA
GO:0031386
F8VSP7 (UniProtKB)
IEA
GO:0004842
F8VVY2 (UniProtKB)
IEA
GO:0008270
F8VVY2 (UniProtKB)
IEA
GO:0016567
F8VVY2 (UniProtKB)
IEA
GO:0016881
F8VVY2 (UniProtKB)
IEA
GO:0031386
F8VVY2 (UniProtKB)
IEA
GO:0000209
Q9H4P4 (UniProtKB)
IDA
GO:0000209
Q9H4P4 (UniProtKB)
IDA
GO:0000209
Q9H4P4 (UniProtKB)
IDA
GO:0004842
Q9H4P4 (UniProtKB)
IDA
GO:0004842
Q9H4P4 (UniProtKB)
IDA
GO:0004842
Q9H4P4 (UniProtKB)
IDA
GO:0004842
Q9H4P4 (UniProtKB)
TAS
GO:0005128
Q9H4P4 (UniProtKB)
IEA
GO:0005135
Q9H4P4 (UniProtKB)
IEA
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005515
Q9H4P4 (UniProtKB)
IPI
GO:0005829
Q9H4P4 (UniProtKB)
TAS
GO:0005829
Q9H4P4 (UniProtKB)
TAS
GO:0005829
Q9H4P4 (UniProtKB)
TAS
GO:0005829
Q9H4P4 (UniProtKB)
TAS
GO:0005829
Q9H4P4 (UniProtKB)
TAS
GO:0005829
Q9H4P4 (UniProtKB)
TAS
GO:0005829
Q9H4P4 (UniProtKB)
TAS
GO:0006914
Q9H4P4 (UniProtKB)
IEA
GO:0008270
Q9H4P4 (UniProtKB)
IEA
GO:0008285
Q9H4P4 (UniProtKB)
IDA
GO:0010498
Q9H4P4 (UniProtKB)
IDA
GO:0016881
Q9H4P4 (UniProtKB)
IEA
GO:0017160
Q9H4P4 (UniProtKB)
IPI
GO:0017160
Q9H4P4 (UniProtKB)
IPI
GO:0030336
Q9H4P4 (UniProtKB)
IMP
GO:0031386
Q9H4P4 (UniProtKB)
IEA
GO:0038128
Q9H4P4 (UniProtKB)
TAS
GO:0043408
Q9H4P4 (UniProtKB)
IDA
GO:0045619
Q9H4P4 (UniProtKB)
IEA
GO:0045637
Q9H4P4 (UniProtKB)
IEA
GO:0051091
Q9H4P4 (UniProtKB)
IEA
GO:0051865
Q9H4P4 (UniProtKB)
IDA
GO:0051896
Q9H4P4 (UniProtKB)
IDA
GO:0061630
Q9H4P4 (UniProtKB)
IDA
GO:0097191
Q9H4P4 (UniProtKB)
IDA
GO:2000114
Q9H4P4 (UniProtKB)
IEA
GO:2000377
Q9H4P4 (UniProtKB)
IMP
GO:2000379
Q9H4P4 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 RNF41基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Parkinson Disease 0.002367032 1 0 GAD
Tumor Progression 0.001085767 4 0 BeFree
Neoplasm Metastasis 0.000814326 3 0 BeFree
Mammary Neoplasms 0.000814326 3 0 BeFree
Malignant neoplasm of breast 0.000814326 3 0 BeFree
Breast Carcinoma 0.000814326 3 0 BeFree
Colorectal Cancer 0.000814326 3 0 BeFree
Colorectal Carcinoma 0.000814326 3 0 BeFree
Anxiety Disorders 0.000271442 1 0 BeFree
Chronic Lymphocytic Leukemia 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

Lung cancer cell-derived exosomal EHF drives M2 macrophage polarization via transcriptional activation of RNF41 to promote tumor progression.
Chen Z, Ying J, Huang G, Shang W, Shi K, Wang Z, Wang L, Ding D, Zhang C, Tan Y Regen Ther IF: 4.0 2026-06-00
Protein microarray characterization of the S-nitrosoproteome.
Lee Yun-Il, Giovinazzo Daniel, Kang Ho Chul, Lee Yunjong, Jeong Jun Seop, Doulias Paschalis-Thomas, Xie Zhi, Hu Jianfei, Ghasemi Mehdi, Ischiropoulos Harry, Qian Jiang, Zhu Heng, Blackshaw Seth, Dawson Valina L, Dawson Ted M Mol Cell Proteomics IF: 6.540 2014-08-18
A large QTL for fear and anxiety mapped using an F2 cross can be dissected into multiple smaller QTLs.
Parker C C, Sokoloff G, Leung E, Kirkpatrick S L, Palmer A A Genes Brain Behav IF: 2.4 2014-07-16
Phosphorylation of the E3 ubiquitin ligase RNF41 by the kinase Par-1b is required for epithelial cell polarity.
Lewandowski Katherine T, Piwnica-Worms Helen J Cell Sci IF: 3.9 2014-10-14
Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing.
De Ceuninck Leentje, Wauman Joris, Masschaele Delphine, Peelman Frank, Tavernier Jan J Cell Sci IF: 3.9 2014-06-15
RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding.
Wauman Joris, De Ceuninck Leentje, Vanderroost Nele, Lievens Sam, Tavernier Jan J Cell Sci IF: 3.9 2011-06-13
Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL).
Hanlon Katy, Rudin Claudius E, Harries Lorna W PLoS One IF: 2.6 2010-02-01
Apollon/RNF41 myocardial messenger RNA diagnoses cardiac allograft apoptosis in rejection.
Aharinejad Seyedhossein, Andrukhova Olena, Gmeiner Matthias, Thomas Anita, Krenn Katharina, Zuckermann Andreas, Grimm Michael Transplantation IF: 4.9 2010-02-24
Transcriptional profile analysis of RPGRORF15 frameshift mutation identifies novel genes associated with retinal degeneration.
Genini Sem, Zangerl Barbara, Slavik Julianna, Acland Gregory M, Beltran William A, Aguirre Gustavo D Invest Ophthalmol Vis Sci IF: 5.5 2010-12-07

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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