RARB (retinoic acid receptor beta)

Gene Basic Information

Gene Basic Information

symbol
RARB
locus group
protein-coding gene
location
3p24.2
gene_family
Nuclear hormone receptors
alias symbol
HAP|NR1B2|RRB2|RARbeta|RAR-beta
alias name
None
entrez id
5915
ensembl gene id
ENSG00000077092
ucsc gene id
uc003cdh.4
refseq accession
NM_000965|NM_016152
hgnc_id
HGNC:9865
approved reserved
1989-05-16

Chromosome Location

Chromosome Location

3p24.2

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]

OMIM entry for RARB     Wikipedia entry for RARB

Gene Sequence

Gene Sequence

Nucleotide sequence of RARB:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MTTSGHACPV PAVNGHMTHY PATPYPLLFP PVIGGLSLPP
41LHGLHGHPPP SGCSTPSPAT IETQSTSSEE LVPSPPSPLP
81 PPRVYKPCF VCQDKSSGYH YGVSACEGCK GFFRRSIQKN
121MIYTCHRDKN CVINKVTRNR CQYCRLQKCF EVGMSKESVR
161N DRNKKKKE TSKQECTESY EMTAELDDLT EKIRKAHQET
201FPSLCQLGKY TTNSSADHRV RLDLGLWDKF SELATKCIIK
241IV EFAKRLP GFTGLTIADQ ITLLKAACLD ILILRICTRY
281TPEQDTMTFS DGLTLNRTQM HNAGFGPLTD LVFTFANQLL
321PLE MDDTET GLLSAICLIC GDRQDLEEPT KVDKLQEPLL
361EALKIYIRKR RPSKPHMFPK ILMKITDLRS ISAKGAERVI
401TLKM EIPGS MPPLIQEMLE NSEGHEPLTP SSSGNTAEHS
441PSISPSSVEN SGVSQSPLVQ
Structure predicted by AlphaFold DB(UniProt: P10826). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of RARB:           Showing partial SNPs
rs1159899       rs1384901       rs1483844       rs2291296       rs2306623       rs2306624       rs6765860       rs6781619       rs6784498       rs6800388       rs7627850       rs9817799       rs9832598       rs11129198       rs11401651       rs11421888       rs11917383      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TTTGCTAAACGTCTGCCTG
59
TTCTAAGAATCAGGATGTCCAGG
60
GTCCAAAGAATAATTCCAGTGC
58
AATAATGCACTTGGTGGCC
59
TTTGCTAAACGTCTGCCTG
59
TTCTAAGAATCAGGATGTCCAGG
60
CCAAAGAATCTGTCAGGAATGAC
60
CAGCTGTCATTTCATAGCTCTC
59
TTTGCTAAACGTCTGCCTG
59
TTCTAAGAATCAGGATGTCCAGG
60
CCTGTGAGGGATGTAAGGG
59
CATTCCTGACAGATTCTTTGGAC
59
GTCATCGGAGGACTTTCCC
60
CTGTGTTTCAATTGTTGCCG
59
CAGTGCTAAAGGTGCAGAG
58
AGCATTTCTTGAATGAGAGGTG
59
CTTAATCTGTGGAGACCGC
58
TTTAGTGCTTCCAGCAATGG
59
TCAAAGCATGCTTCAGTGG
58
ATTGATTGAGCAGTGTGCC
58

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
FOXD3
RARB
Activation
23058321
HDAC1
RARB
Repression
14731134
JUN
RARB
Activation
9377582
PPARG
RARB
Activation
12839938
RARA
RARB
Activation
10629091
RARB
ADH5
Unknown
1996113
RARB
RARB
Activation
12767074
RARB
THBD
Unknown
11036068
RARG
RARB
Unknown
1310259
SNW1
RARB
Unknown
19934264

Gene Ontology

Subcellular localization of RARB (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RARB:

GO ID
Protein
Source DB
GO:0003707
D6RBI3 (UniProtKB)
IEA
GO:0003708
D6RBI3 (UniProtKB)
IEA
GO:0005634
D6RBI3 (UniProtKB)
IEA
GO:0006351
D6RBI3 (UniProtKB)
IEA
GO:0006355
D6RBI3 (UniProtKB)
IEA
GO:0008270
D6RBI3 (UniProtKB)
IEA
GO:0043401
D6RBI3 (UniProtKB)
IEA
GO:0043565
D6RBI3 (UniProtKB)
IEA
GO:0048384
D6RBI3 (UniProtKB)
IEA
GO:0000122
P10826 (UniProtKB)
IEA
GO:0000977
P10826 (UniProtKB)
IEA
GO:0001657
P10826 (UniProtKB)
IEA
GO:0002068
P10826 (UniProtKB)
IEA
GO:0003148
P10826 (UniProtKB)
IEA
GO:0003406
P10826 (UniProtKB)
IEA
GO:0003417
P10826 (UniProtKB)
IEA
GO:0003677
P10826 (UniProtKB)
TAS
GO:0003707
P10826 (UniProtKB)
IEA
GO:0003708
P10826 (UniProtKB)
IEA
GO:0005515
P10826 (UniProtKB)
IPI
GO:0005515
P10826 (UniProtKB)
IPI
GO:0005515
P10826 (UniProtKB)
IPI
GO:0005515
P10826 (UniProtKB)
IPI
GO:0005634
P10826 (UniProtKB)
IDA
GO:0005654
P10826 (UniProtKB)
IDA
GO:0005654
P10826 (UniProtKB)
TAS
GO:0005654
P10826 (UniProtKB)
TAS
GO:0005654
P10826 (UniProtKB)
TAS
GO:0005737
P10826 (UniProtKB)
IEA
GO:0006367
P10826 (UniProtKB)
TAS
GO:0007165
P10826 (UniProtKB)
TAS
GO:0008144
P10826 (UniProtKB)
IEA
GO:0008270
P10826 (UniProtKB)
IEA
GO:0008284
P10826 (UniProtKB)
IEA
GO:0008285
P10826 (UniProtKB)
IEA
GO:0021756
P10826 (UniProtKB)
IEA
GO:0031641
P10826 (UniProtKB)
IEA
GO:0032331
P10826 (UniProtKB)
IEA
GO:0032403
P10826 (UniProtKB)
IEA
GO:0035116
P10826 (UniProtKB)
IEA
GO:0035264
P10826 (UniProtKB)
IEA
GO:0043065
P10826 (UniProtKB)
IEA
GO:0043066
P10826 (UniProtKB)
IEA
GO:0043401
P10826 (UniProtKB)
IEA
GO:0045666
P10826 (UniProtKB)
IEA
GO:0045944
P10826 (UniProtKB)
IEA
GO:0046965
P10826 (UniProtKB)
IEA
GO:0048048
P10826 (UniProtKB)
IEA
GO:0048384
P10826 (UniProtKB)
IEA
GO:0048566
P10826 (UniProtKB)
IMP
GO:0055012
P10826 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating RARB:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
MICROPHTHALMIA, SYNDROMIC 12 0.24 1 3 CLINVAR_UNIPROT
Squamous cell carcinoma 0.13361182 15 0 BeFree_CTD_human_LHGDN
Mammary Neoplasms 0.131711727 8 0 BeFree_CTD_human_LHGDN
Lung Neoplasms 0.131168843 6 0 BeFree_CTD_human_LHGDN
Head and Neck Neoplasms 0.12272435 2 0 CTD_human_LHGDN
Adenocarcinoma 0.120271442 2 0 BeFree_CTD_human
Stomach Neoplasms 0.120271442 2 0 BeFree_CTD_human
Uterine Cervical Neoplasm 0.12 1 0 CTD_human
Sciatic Neuropathy 0.12 1 0 CTD_human
Endometriosis 0.12 1 0 CTD_human

Related Publications

Related Publications

The dual role of retinoic acid signaling in clear cell renal cell carcinoma and wilms tumor: A tale of two entities.
Qiang SHI, Zehua LI, Huilin FU, Haifeng SHI, Jie GU Biochim Biophys Acta Rev Cancer IF: 11.2 2026-07-23
The methylation of LHX2, RAPGEFL1, RARB and RYR2 has prognostic significance in head and neck squamous cell carcinoma patients.
Skalski M, Kowal-Wiśniewska E, Jaskiewicz-Rajewicz K, Kiwerska K, Bartochowska A, Ustaszewski A, Górecki T, Majchrzak-Celińska A, Wierzbicka M, Jarmuż-Szymczak M, Paluszczak J J Appl Genet IF: 2.1 2026-03-02
Characterization of Ocular Developmental Disorders in the Israeli Population: Genotype-Phenotype Correlations and Novel Candidate Genes.
Rabinovich Y, Vardizer Y, Pincovich S, Wolowelsky M, Kulyamzin S, Ehrenberg M, Zayit-Soudry S, Man Peles I, Leibu R, Goldenberg-Cohen N, Ben-Yosef T Biomolecules 2026-08-21
Molecular and Clinical Analyses of 111 Patients with Bilateral Anterior-Segment Dysgenesis/Aniridia and Microphthalmia/Anophthalmia.
Nishina S, Anzai H, Yoshida T, Koyanagi Y, Kamada S, Kato K, Torii K, Hikoya A, Kondo M, Sotozono C, Matsubara K, Fukami M Ophthalmol Sci IF: 5.0 2026-10-00
Circulating DNA-Markers of High Risk for Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease.
Ponomaryova AA, Boyarko VV, Wang L, Huang Z, Korobeynikova AA, Gervas PA, Kapitanova DV, Bukreeva EB, Pancova OV, Zarubin AA, Perelmuter VM, Cherdyntseva NV, Denisov EV Bull Exp Biol Med IF: 0.7 2026-03-00
Molecular Links Between Smoking, COPD, and Lung Cancer: A DNA Methylation Perspective.
Forigua CB, Bermúdez LG, Cañas Arboleda A, Ariza RR, Roldán MT, Morales MT, González Cubides DM, Rojas A Cancers (Basel) 2026-04-17
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Isa MM, Syukri M, Muchlisin ZA, Gunadi, Syahputra DA, Yusriadi T, Muzakkir Y, Kamarlis RK, Effendy Z, Setyadi A, Maghfirah S, Rinanda T Pediatr Surg Int IF: 1.8 2026-05-08
Clinical features of syndromic microphthalmia in two novel RARB variants.
Koyanagi Y, Morikawa-Anzai H, Yoshida T, Tominaga M, Abe Y, Kosaki R, Matsubara K, Fukami M, Nishina S Hum Genome Var 2026-04-06
Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular mechanisms underlying clutch length differences in goose ovaries.
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