RPS6基因详情-基因数据库-基因云馆

RPS6 (ribosomal protein S6)

symbol:: RPS6
locus group:: protein-coding gene
location:: 9p22.1
gene_family:: S ribosomal proteins
alias symbol:: S6
alias name:: 40S ribosomal protein S6|phospho...
entrez id:: 6194
ensembl gene id:: ENSG00000137154
ucsc gene id:: uc003znv.2
refseq accession:: NM_001010
hgnc_id:: HGNC:10429
approved reserved:: 1990-07-06

9p22.1

RPS6（核糖体蛋白S6）是核糖体40S小亚基的重要组成部分，属于RPS（核糖体蛋白小亚基）基因家族。该家族成员普遍参与核糖体组装和蛋白质翻译过程，其共性是与rRNA结合形成核糖体结构，直接调控mRNA的翻译效率。RPS6的生物学功能集中在促进核糖体生物发生和蛋白质合成，尤其在细胞生长、增殖和代谢中起核心作用。它的主要作用位点是细胞质中的核糖体，但磷酸化后的RPS6可进入细胞核调控特定基因转录。当RPS6发生突变时，可能导致核糖体功能异常，引发核糖体病（ribosomopathy），典型表现为发育迟缓、贫血或癌症易感性。例如，DBA（Diamond-Blackfan贫血）患者中已发现RPS6突变导致红细胞生成障碍。该基因与mTOR信号通路密切关联，其磷酸化状态（即激活形式）受mTORC1调控，因此过表达会增强蛋白质合成，促进细胞增殖，常见于多种肿瘤（如乳腺癌、肝癌）；而低表达则导致翻译效率下降，影响组织再生或胚胎发育。在基因家族层面，RPS6与其他RPS成员协同维持核糖体结构完整性，但独特之处在于其作为mTOR通路下游效应分子，能整合生长信号与翻译调控。目前中文术语"核糖体蛋白S6"为规范译名，无显著争议。

中文English

核糖体，催化蛋白质合成的细胞器，由一个小40S亚基和60S大亚基。一起这些亚基组成的4 RNA种类和大约80结构不同的蛋白质。这个基因编码细胞质核糖体蛋白，它是40S亚基的一个组成部分。该蛋白属于S6E家族核糖体的蛋白质。它是在核糖体的蛋白激酶的主要底物，具有由不同的蛋白激酶磷酸化5 C-末端丝氨酸残基的子集。磷酸化是由广泛的刺激，包括生长因子，肿瘤促进剂，以及促分裂原诱导的。去磷酸化发生在生长停滞。该蛋白可能有助于细胞生长和增殖的通过特定类别的mRNA的选择性翻译的控制。作为典型编码核糖体蛋白的基因，有该基因通过基因组分散的多个经处理的假基因。 [由RefSeq的，2008年7月提供]

OMIM数据库中对RPS6基因的介绍 Wikipedia数据库中对RPS6基因的介绍

RPS6基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA
41LGEEWKGYVV RISGGNDKQG FPMKQGVLTH GRVRLLLSKG
81
HSCYRPRRT GERKRKSVRG CIVDANLSVL NLVIVKKGEK
121DIPGLTDTTV PRRLGPKRAS RIRKLFNLSK EDDVRQYVVR
161K
PLNKEGKK PRTKAPKIQR LVTPRVLQHK RRRIALKKQR
201TKKNKEEAAE YAKLLAKRMK EAKEKRQEQI AKRRRLSSLR
241AS
TSKSESS QK

结构预测来自 AlphaFold DB（UniProt: P62753），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

RPS6基因的碱基突变：仅显示部分snp

rs957 rs983 rs1143622 rs1804397 rs2277151 rs2301239 rs3085561 rs3198076 rs3206714 rs3209385 rs3209386 rs7851736 rs10119465 rs11541612 rs11541619 rs11541621 rs12001628

RPS6基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GAATGAAGGAGGCTAAGGAG

58

TTAGAAGTAGAAGCTCGCAG

57

AAGCTGAACATCTCCTTCCC

60

CACATAACCCTTCCATTCTTCAC

60

AGATGAAGCTGAACATCTCCT

59

AGAAAGTACGAAGTTTGCGT

58

AAGAATGGAAGGGTTATGTGGT

60

CCCTTACTCAGTAGCAGGC

60

GAATGAAGGAGGCTAAGGAG

57

TTAGAAGTAGAAGCTCGCAG

57

AAGAATGGAAGGGTTATGTGGT

60

CCCTTACTCAGTAGCAGGC

60

AGAATGGAAGGGTTATGTGGT

59

CCCTTACTCAGTAGCAGGC

60

AGAATGAAGGAGGCTAAGGAG

59

AGAAGTAGAAGCTCGCAGAG

59

AGATGAAGCTGAACATCTCC

57

AGAAAGTACGAAGTTTGCGT

58

AGAATGGAAGGGTTATGTGGT

59

CCCTTACTCAGTAGCAGGC

60

尚未收录相关数据

RPS6基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

RPS6基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0003735

A2A3R5 (UniProtKB)

IEA

GO:0005737

A2A3R5 (UniProtKB)

IDA

GO:0005840

A2A3R5 (UniProtKB)

IEA

GO:0006412

A2A3R5 (UniProtKB)

IEA

GO:0003735

A2A3R7 (UniProtKB)

IEA

GO:0005840

A2A3R7 (UniProtKB)

IEA

GO:0006412

A2A3R7 (UniProtKB)

IEA

GO:0000082

P62753 (UniProtKB)

IEA

GO:0000184

P62753 (UniProtKB)

TAS

GO:0001890

P62753 (UniProtKB)

IEA

GO:0002309

P62753 (UniProtKB)

IEA

GO:0003735

P62753 (UniProtKB)

IEA

GO:0005515

P62753 (UniProtKB)

IPI

GO:0005515

P62753 (UniProtKB)

IPI

GO:0005515

P62753 (UniProtKB)

IPI

GO:0005515

P62753 (UniProtKB)

IPI

GO:0005634

P62753 (UniProtKB)

IDA

GO:0005634

P62753 (UniProtKB)

IDA

GO:0005654

P62753 (UniProtKB)

TAS

GO:0005654

P62753 (UniProtKB)

TAS

GO:0005654

P62753 (UniProtKB)

TAS

GO:0005654

P62753 (UniProtKB)

TAS

GO:0005654

P62753 (UniProtKB)

TAS

GO:0005730

P62753 (UniProtKB)

IDA

GO:0005737

P62753 (UniProtKB)

IDA

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005829

P62753 (UniProtKB)

TAS

GO:0005844

P62753 (UniProtKB)

IEA

GO:0006364

P62753 (UniProtKB)

IMP

GO:0006364

P62753 (UniProtKB)

TAS

GO:0006412

P62753 (UniProtKB)

IC

GO:0006412

P62753 (UniProtKB)

IC

GO:0006413

P62753 (UniProtKB)

TAS

GO:0006614

P62753 (UniProtKB)

TAS

GO:0006924

P62753 (UniProtKB)

IEA

GO:0007067

P62753 (UniProtKB)

IEA

GO:0007093

P62753 (UniProtKB)

IEA

GO:0007369

P62753 (UniProtKB)

IEA

GO:0015935

P62753 (UniProtKB)

IDA

GO:0016020

P62753 (UniProtKB)

IDA

GO:0019083

P62753 (UniProtKB)

TAS

GO:0019901

P62753 (UniProtKB)

IPI

GO:0022605

P62753 (UniProtKB)

IEA

GO:0022627

P62753 (UniProtKB)

NAS

GO:0022627

P62753 (UniProtKB)

IDA

GO:0022627

P62753 (UniProtKB)

IDA

GO:0030425

P62753 (UniProtKB)

IDA

GO:0030529

P62753 (UniProtKB)

IDA

GO:0031929

P62753 (UniProtKB)

IDA

GO:0033077

P62753 (UniProtKB)

IEA

GO:0036464

P62753 (UniProtKB)

IDA

GO:0042274

P62753 (UniProtKB)

IMP

GO:0042593

P62753 (UniProtKB)

ISS

GO:0043065

P62753 (UniProtKB)

IDA

GO:0043066

P62753 (UniProtKB)

IEA

GO:0044297

P62753 (UniProtKB)

IDA

GO:0044822

P62753 (UniProtKB)

IDA

GO:0048471

P62753 (UniProtKB)

IEA

GO:0048821

P62753 (UniProtKB)

IEA

可能调控 RPS6基因的相关microRNA：

hsa-miR-16 hsa-let-7d hsa-miR-1260b hsa-miR-15b hsa-miR-182* hsa-miR-652 hsa-miR-744 hsa-miR-99a

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
3010 Ribosome [PATH:hsa03010]
4066 HIF-1 signaling pathway [PATH:hsa04066]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4150 mTOR signaling pathway [PATH:hsa04150]
4910 Insulin signaling pathway [PATH:hsa04910]
5205 Proteoglycans in cancer [PATH:hsa05205]

名称
3' -UTR-mediated translational regulation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Disease
Eukaryotic Translation Elongation
Eukaryotic Translation Initiation
Eukaryotic Translation Termination
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Gene Expression
GTP hydrolysis and joining of the 60S ribosomal subunit
IGF1R signaling cascade
Infectious disease
Influenza Infection
Influenza Life Cycle
Influenza Viral RNA Transcription and Replication
Insulin receptor signalling cascade
IRS-mediated signalling
IRS-related events
IRS-related events triggered by IGF1R
L13a-mediated translational silencing of Ceruloplasmin expression
Metabolism of proteins
mTOR signalling
mTORC1-mediated signalling
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Peptide chain elongation
PI3K Cascade
PKB-mediated events
Ribosomal scanning and start codon recognition
S6K1 signalling
S6K1-mediated signalling
Signaling by Insulin receptor
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
SRP-dependent cotranslational protein targeting to membrane
Translation
Translation initiation complex formation
Viral mRNA Translation

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Liver carcinoma	0.120542884	3	0	BeFree_CTD_human
Disease Progression	0.12	1	0	CTD_human
Mammary Neoplasms	0.12	1	0	CTD_human
Stomach Neoplasms	0.12	1	0	CTD_human
Tuberous Sclerosis	0.002995792	2	0	BeFree_LHGDN
Motor Neuron Disease	0.00272435	1	0	LHGDN
Coffin-Lowry syndrome	0.000814326	3	0	BeFree
Colorectal Carcinoma	0.000271442	1	0	BeFree
Alzheimer's Disease	0.000271442	1	0	BeFree
Leukemia, Myelocytic, Acute	0.000271442	1	0	BeFree

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Insights from changes in NDEV biomarkers of metabolism: Effects of PPARγ and GLP1 receptor agonists on brain metabolism.

Evers A, Watson K, Abbasi F, Haque K, Verma A, Eitan E, Rasgon N J Clin Endocrinol Metab IF: 5.4 2026-04-17

The effects of valine, lysine and threonine and their optimal combinations on the synthesis of α-casein by MAC-T cells.

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Intracellular GRP78-Directed Delivery of Rapamycin by Biomolecular Condensates of Hydra-Elastin-like Polypeptides.

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Efficacy of 5-fluorouracil and metronomic chemotherapy mediated ornithine decarboxylase antizyme for inhibiting of colorectal cancer.

Zou Q, Chen X, Liu Q, Xia D, Gui L J Bioenerg Biomembr IF: 3.7 2026-03-19

Association between omeprazole and memory impairment: Insights from NHANES data analysis and network pharmacology studies.

Zhang H, Zeng QY, Liu C, Wu Y, Liu JK, Wang FH, Luo X J Alzheimers Dis IF: 3.4 2026-05-00

A three generation family with VACTERL association is found to have a rare form of diamond-blackfan anaemia.

Leshchynska I, Das D, O'Reilly V, Sipka A, Iyer K, Alankarage D, Rath E, Kumar A, Kurt BA, Voydanoff ME, Congenital Heart Disease Synergy Study group, Stevenson RE, Winlaw DS, Ascher DB, Giannoulatou E, Mark PR, Dunwoodie SL, Chapman G Eur J Hum Genet IF: 4.6 2026-05-00

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The Content of Small 18S rRNA Fragments Is Regulated Developmentally and in Response to Stress in Plants.

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RPS6 (ribosomal protein S6)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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