RXRG (retinoid X receptor gamma)

Gene Basic Information

Gene Basic Information

symbol
RXRG
locus group
protein-coding gene
location
1q23.3
gene_family
Nuclear hormone receptors
alias symbol
NR2B3|RXRgamma|RXR-gamma
alias name
nuclear receptor subfamily 2 group…
entrez id
6258
ensembl gene id
ENSG00000143171
ucsc gene id
uc001gda.4
refseq accession
NM_006917
hgnc_id
HGNC:10479
approved reserved
1991-11-14

Chromosome Location

Chromosome Location

1q23.3

Gene Summary

Gene Summary

ChineseEnglish

RXRG, or Retinoid X Receptor Gamma, is a member of the RXR subfamily within the nuclear receptor superfamily, which also includes RXRA and RXRB, and functions as a ligand-dependent transcription factor that regulates gene expression primarily through the binding of 9-cis retinoic acid. Highly expressed in the central nervous system, skeletal muscle, and adipose tissue, RXRG plays a pivotal role in retinoic acid signaling, lipid metabolism, cell differentiation, and neurodevelopment by forming heterodimers with other nuclear receptors such as RARs, PPARs, and LXRs. These receptor complexes bind to specific DNA sequences, including direct repeat 1 (DR1) elements, in the promoter regions of target genes to modulate the transcription of downstream effectors like the metabolic enzyme CYP26A1 and the neurodevelopmental factor BDNF. Disruptions in RXRG function, whether through loss-of-function mutations that impair dimerization or overexpression that hyperactivates retinoic acid signaling, can lead to pathological outcomes ranging from metabolic disorders such as diabetes and lipid dysregulation to neurological conditions including schizophrenia, autism spectrum disorder, and abnormal cellular differentiation associated with tumorigenesis, underscoring the critical balance required in RXRG-mediated transcriptional control for maintaining homeostasis in development and metabolic processes.

OMIM entry for RXRG     Wikipedia entry for RXRG

Gene Sequence

Gene Sequence

Nucleotide sequence of RXRG:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD
41SHPSYTDTPV SAPRTLSAVG TPLNALGSPY RVITSAMGPP
81 SGALAAPPG INLVAPPSSQ LNVVNSVSSS EDIKPLPGLP
121GIGNMNYPST SPGSLVKHIC AICGDRSSGK HYGVYSCEGC
161K GFFKRTIR KDLIYTCRDN KDCLIDKRQR NRCQYCRYQK
201CLVMGMKREA VQEERQRSRE RAESEAECAT SGHEDMPVER
241IL EAELAVE PKTESYGDMN MENSTNDPVT NICHAADKQL
281FTLVEWAKRI PHFSDLTLED QVILLRAGWN ELLIASFSHR
321SVS VQDGIL LATGLHVHRS SAHSAGVGSI FDRVLTELVS
361KMKDMQMDKS ELGCLRAIVL FNPDAKGLSN PSEVETLREK
401VYAT LEAYT KQKYPEQPGR FAKLLLRLPA LRSIGLKCLE
441HLFFFKLIGD TPIDTFLMEM LETPLQIT
Structure predicted by AlphaFold DB(UniProt: P48443). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of RXRG:           Showing partial SNPs
rs100537       rs113471       rs157861       rs157862       rs157863       rs157864       rs157865       rs157866       rs157867       rs157868       rs157869       rs157870       rs157871       rs157872       rs157873       rs157874       rs157875      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GCTCTCAGCTAAATGTGGT
58
GTTCATGTTTCCAATCCCG
57
GTTCTCGCCTAAATGTGGT
58
GTTCATGTTTCCAATCCCG
57
AGAGGAACATGAACTGACGA
59
AAGAACACCCTCCATAGCC
59
ACTCTTTAACCCAGATGCCA
59
CTCAAGGGTGGCATAAACC
59
CAGATCCTCAGGAAAGCAC
58
AGGTCCTTCCTTATCGTCC
58
ACTCTTTAACCCAGATGCCA
59
TCAAGGGTGGCATAAACCT
59
ACAGATCCTCAGGAAAGCAC
60
GGTCCTTCCTTATCGTCCTC
59
GTTCTCGCCTAAATGTGGTC
59
TTCATGTTTCCAATCCCGG
58
AGGAACATGAACTGACGAG
57
GAAGAACACCCTCCATAGC
58
GCTCTCAGCTAAATGTGGTC
59
TTCATGTTTCCAATCCCGG
58

Gene Ontology

Subcellular localization of RXRG (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RXRG:

GO ID
Protein
Source DB
GO:0003700
A0A087WZ88 (UniProtKB)
IEA
GO:0003707
A0A087WZ88 (UniProtKB)
IEA
GO:0005634
A0A087WZ88 (UniProtKB)
IEA
GO:0006351
A0A087WZ88 (UniProtKB)
IEA
GO:0006355
A0A087WZ88 (UniProtKB)
IEA
GO:0008270
A0A087WZ88 (UniProtKB)
IEA
GO:0043401
A0A087WZ88 (UniProtKB)
IEA
GO:0043565
A0A087WZ88 (UniProtKB)
IEA
GO:0000977
P48443 (UniProtKB)
IEA
GO:0003707
P48443 (UniProtKB)
IEA
GO:0004886
P48443 (UniProtKB)
IEA
GO:0005515
P48443 (UniProtKB)
IPI
GO:0005515
P48443 (UniProtKB)
IPI
GO:0005515
P48443 (UniProtKB)
IPI
GO:0005515
P48443 (UniProtKB)
IPI
GO:0005515
P48443 (UniProtKB)
IPI
GO:0005515
P48443 (UniProtKB)
IPI
GO:0005515
P48443 (UniProtKB)
IPI
GO:0005515
P48443 (UniProtKB)
IPI
GO:0005515
P48443 (UniProtKB)
IPI
GO:0005515
P48443 (UniProtKB)
IPI
GO:0005515
P48443 (UniProtKB)
IPI
GO:0005654
P48443 (UniProtKB)
TAS
GO:0005654
P48443 (UniProtKB)
TAS
GO:0005654
P48443 (UniProtKB)
TAS
GO:0006367
P48443 (UniProtKB)
TAS
GO:0008270
P48443 (UniProtKB)
IEA
GO:0043401
P48443 (UniProtKB)
IEA
GO:0048384
P48443 (UniProtKB)
IEA
GO:0051289
P48443 (UniProtKB)
IEA
GO:1901522
P48443 (UniProtKB)
IEA

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Myocardial Ischemia 0.12 1 0 CTD_human
Bipolar Disorder 0.12 1 1 GWASCAT
Diabetes Mellitus, Non-Insulin-Dependent 0.005005506 2 1 BeFree_GAD
Hyperlipidemia, Familial Combined 0.002995792 1 0 BeFree_LHGDN
Thyroid Neoplasm 0.00272435 1 0 LHGDN
Hyperplasia 0.00272435 1 0 LHGDN
Obesity 0.002367032 1 0 GAD
Inflammation 0.002367032 1 0 GAD
Acquired Immunodeficiency Syndrome 0.002367032 1 1 GAD
Osteoporosis 0.002367032 1 0 GAD

Related Publications

Related Publications

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Wang L, Liu L, Bai Y, Wang Y, Zheng C, Wang J, Chang S, Mao Z, Liu X, Gao Y Poult Sci IF: 4.5 2026-06-00
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Zhuang S, Yang X, Zhang N, Liu J, Liu K, Han H, Zhai S, Liu M, Liang H, Gu Y, Lu Y PLoS Comput Biol IF: 4.867 2026-03-00
Integrative single-nucleus transcriptomic analysis identifies UBE2C+ proliferative tumor cells and immune-stromal regulatory crosstalk in small cell lung cancer.
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In Silico Multitarget Profiling of Betulinic Acid: ADME/Protox-II Toxicity, Network Pharmacology, and Molecular Docking for Diabetic Osteoporosis.
Sharma S, Chaudhary R, Sharma C, Dabral S, Bansal S, Sharma N, Gupta S Curr Drug Discov Technol 2026-08-06
Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.
Weir K, Lyu P, Kandoi S, An R, Pannullo N, Palazzo I, Tangeman JA, Shi J, DeVries SH, Merriman DK, Qian J, Blackshaw S Elife IF: nan 2026-02-06
The symptomatology of Attention-Deficit/Hyperactivity Disorder and the genetic control of vitamin D levels.
Bandeira CE, das Neves FGP, Rovaris DL, Grevet EH, Dias-Soares M, da Silva C, Dresch F, da Silva BS, Bau CHD, Shansis FM, Genro JP, Contini V Nutr Neurosci IF: 3.1 2025-01-00

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