SEMG1 (semenogelin 1)

Gene Basic Information

Gene Basic Information

symbol:
SEMG1
locus group:
protein-coding gene
location:
20q13.12
gene_family:
alias symbol:
CT103
alias name:
semen coagulating protein|cancer/t…
entrez id:
6406
ensembl gene id:
ENSG00000124233
ucsc gene id:
uc002xni.3
refseq accession:
NM_003007
hgnc_id:
HGNC:10742
approved reserved:
1991-09-13

Chromosome Location

Chromosome Location

20q13.12

Gene Summary

Gene Summary

ChineseEnglish

The protein encoded by this gene is a major constituent of semen. This secreted protein participates in the formation of the gel matrix that entraps ejaculated sperm. Prostate-specific antigen (PSA) proteolytically processes the protein into smaller peptides, each potentially possessing distinct functions. This proteolytic process liquefies the gel matrix, thereby facilitating increased sperm motility. Additionally, the antimicrobial peptide SGI-29, derived from this protein, exhibits antibacterial activity. [Provided by RefSeq, Nov 2014]

OMIM entry for SEMG1     Wikipedia entry for SEMG1

Gene Sequence

Gene Sequence

Nucleotide sequence of SEMG1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MKPNIIFVLS LLLILEKQAA VMGQKGGSKG RLPSEFSQFP
41HGQKGQHYSG QKGKQQTESK GSFSIQYTYH VDANDHDQSR
81 KSQQYDLNA LHKTTKSQRH LGGSQQLLHN KQEGRDHDKS
121KGHFHRVVIH HKGGKAHRGT QNPSQDQGNS PSGKGISSQY
161S NTEERLWV HGLSKEQTSV SGAQKGRKQG GSQSSYVLQT
201EELVANKQQR ETKNSHQNKG HYQNVVEVRE EHSSKVQTSL
241CP AHQDKLQ HGSKDIFSTQ DELLVYNKNQ HQTKNLNQDQ
281QHGRKANKIS YQSSSTEERR LHYGENGVQK DVSQSSIYSQ
321TEE KAQGKS QKQITIPSQE QEHSQKANKI SYQSSSTEER
361RLHYGENGVQ KDVSQRSIYS QTEKLVAGKS QIQAPNPKQE
401PWHG ENAKG ESGQSTNREQ DLLSHEQKGR HQHGSHGGLD
441IVIIEQEDDS DRHLAQHLNN DRNPLFT
结构预测来自 AlphaFold DB（UniProt: P04279），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of SEMG1:           Showing partial SNPs
rs2233879       rs2233880       rs2233882       rs2233883       rs2233884       rs2233885       rs2233886       rs2233887       rs2233888       rs2233889       rs2233890       rs2301366       rs2746991       rs2857765       rs3746586       rs6017512       rs6017513      

Gene Expression

Gene Expression

Tissue expression of SEMG1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TAACAACGACCGAAACCCA
60
CAACTGACACCTTGATATTGGT
59
TAACAACGACCGAAACCCA
60
CAACTGACACCTTGATATTGGTC
60
TTAACAACGACCGAAACCC
58
AACTGACACCTTGATATTGGTC
59

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
GATA1
SEMG1
Unknown
18602691

Gene Ontology

Subcellular localization of SEMG1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for SEMG1:

GO ID
Protein
Source DB
GO:0005515
P04279 (UniProtKB)
IPI
GO:0005515
P04279 (UniProtKB)
IPI
GO:0005515
P04279 (UniProtKB)
IPI
GO:0005515
P04279 (UniProtKB)
IPI
GO:0005576
P04279 (UniProtKB)
TAS
GO:0005576
P04279 (UniProtKB)
TAS
GO:0005615
P04279 (UniProtKB)
TAS
GO:0005615
P04279 (UniProtKB)
IDA
GO:0005615
P04279 (UniProtKB)
IDA
GO:0005615
P04279 (UniProtKB)
IDA
GO:0005615
P04279 (UniProtKB)
IDA
GO:0005615
P04279 (UniProtKB)
IDA
GO:0005634
P04279 (UniProtKB)
IDA
GO:0007320
P04279 (UniProtKB)
TAS
GO:0019731
P04279 (UniProtKB)
IDA
GO:0043234
P04279 (UniProtKB)
IDA
GO:0044267
P04279 (UniProtKB)
TAS
GO:0046872
P04279 (UniProtKB)
IMP
GO:0050817
P04279 (UniProtKB)
IDA
GO:0051291
P04279 (UniProtKB)
IDA
GO:0070062
P04279 (UniProtKB)
IDA
GO:0090281
P04279 (UniProtKB)
IDA
GO:1900005
P04279 (UniProtKB)
IMP
GO:1901318
P04279 (UniProtKB)
IMP
GO:1901318
P04279 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating SEMG1:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Malignant neoplasm of testis 0.000814326 3 0 BeFree
Chronic Lymphocytic Leukemia 0.000814326 3 0 BeFree
Tumor Progression 0.000542884 2 0 BeFree
Malignant neoplasm of ovary 0.000542884 2 0 BeFree
Ovarian Carcinoma 0.000542884 2 0 BeFree
Multiple Myeloma 0.000542884 2 0 BeFree
Myeloid Leukemia, Chronic 0.000271442 1 0 BeFree
Congenital bilateral aplasia of vas deferens 0.000271442 1 0 BeFree
Renal Cell Carcinoma 0.000271442 1 0 BeFree

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Smoking Behavior Is Associated With an Altered Immune Landscape in Prostate Cancer: Implications for Patient Outcomes.
Sharma A, Sudan SK, Khan MA, Tahir M, Niyogi PG, Singh AP, Singh S Prostate IF: 2.7 2026-05-00
Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome.
Alvarez Iñaki, Collado Javier A, Colobran Roger, Carrascal Montserrat, Ciudad M Teresa, Canals Françesc, James Eddie A, Kwok William W, Gärtner Martina, Kyewski Bruno, Pujol-Borrell Ricardo, Jaraquemada Dolores J Autoimmun IF: 6.8 2016-03-24
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Légaré Christine, Droit Arnaud, Fournier Frédéric, Bourassa Sylvie, Force André, Cloutier Francine, Tremblay Roland, Sullivan Robert J Proteome Res IF: 3.8 2015-10-19
Evaluation of forensic examination of extremely aged seminal stains.
Nakanishi Hiroaki, Hara Masaaki, Takahashi Shirushi, Takada Aya, Saito Kazuyuki Leg Med (Tokyo) IF: 1.4 2015-05-18
SEMG1 may be the candidate gene for idiopathic asthenozoospermia.
Yu Q, Zhou Q, Wei Q, Li J, Feng C, Mao X Andrologia IF: 1.3 2014-09-29
microRNA-18b is upregulated in breast cancer and modulates genes involved in cell migration.
Fonseca-Sanchéz Miguel A, Pérez-Plasencia Carlos, Fernández-Retana Jorge, Arechaga-Ocampo Elena, Marchat Laurence A, Rodríguez-Cuevas Sergio, Bautista-Piña Veronica, Arellano-Anaya Zaira E, Flores-Pérez Ali, Diaz-Chávez José, López-Camarillo César Oncol Rep IF: 4.7 2014-04-07
Interacting proteins on human spermatozoa: adaptive evolution of the binding of semenogelin I to EPPIN.
Silva Erick J R, Hamil Katherine G, O'Rand Michael G PLoS One IF: 2.6 2014-09-27
RNA/DNA co-analysis from human saliva and semen stains--results of a third collaborative EDNAP exercise.
Haas C, Hanson E, Anjos M J, Banemann R, Berti A, Borges E, Carracedo A, Carvalho M, Courts C, De Cock G, Dötsch M, Flynn S, Gomes I, Hollard C, Hjort B, Hoff-Olsen P, Hríbiková K, Lindenbergh A, Ludes B, Maroñas O, McCallum N, Moore D, Morling N, Niederstätter H, Noel F, Parson W, Popielarz C, Rapone C, Roeder A D, Ruiz Y, Sauer E, Schneider P M, Sijen T, Court D Syndercombe, Sviežená B, Turanská M, Vidaki A, Zatkalíková L, Ballantyne J Forensic Sci Int Genet IF: 3.6 2013-08-05

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