SOX15Gene Detail-Gene Database-Genelibs

SOX15 (SRY-box transcription factor 15)

symbol:: SOX15
locus group:: protein-coding gene
location:: 17p13.1
gene_family:: SRY (sex determining region Y)-boxes
alias symbol:: SOX27|SOX26
alias name:: None
entrez id:: 6665
ensembl gene id:: ENSG00000129194
ucsc gene id:: uc002ghz.2
refseq accession:: NM_006942
hgnc_id:: HGNC:11196
approved reserved:: 1995-09-15

17p13.1

SOX15（SRY-box transcription factor 15）属于SOX基因家族，该家族以含有SRY（性别决定区Y）同源盒（HMG box）为特征，是一类调控胚胎发育、细胞命运决定和组织分化的转录因子。SOX家族成员通过HMG结构域结合DNA，调控靶基因表达，其功能高度依赖细胞类型和发育阶段。SOX15在多种组织中低水平表达，主要参与肌肉分化、神经发育和生殖细胞调控。其表达产物通过激活或抑制下游基因（如肌源性分化因子MyoD）影响细胞分化进程。突变可能导致SOX15功能丧失，与肌肉发育异常或生育障碍相关，但具体机制尚不明确。目前研究发现，SOX15过表达可促进成肌细胞分化，而表达降低可能抑制肌肉再生，并与某些肌营养不良症有关。SOX家族共性包括：依赖HMG盒结合DNA的AT-rich序列（如CAA/TTGT），参与干细胞多能性维持（如SOX2）、性别决定（SOX9）和神经发育（SOX1-3）。SOX15与疾病关联的研究较少，但SOX家族其他成员（如SOX9突变导致 campomelic dysplasia）的致病性提示其潜在临床意义。若需进一步探讨其分子机制或疾病关联，建议结合具体研究模型。

ChineseEnglish

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]

OMIM entry for SOX15 Wikipedia entry for SOX15

Nucleotide sequence of SOX15:[NCBI]

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Protein Sequence

1MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA
41PGTLPLEKVK RPMNAFMVWS SAQRRQMAQQ NPKMHNSEIS
81
KRLGAQWKL LDEDEKRPFV EEAKRLRARH LRDYPDYKYR
121PRRKAKSSGA GPSRCGQGRG NLASGGPLWG PGYATTQPSR
161G
FGYRPPSY STAYLPGSYG SSHCKLEAPS PCSLPQSDPR
201LQGELLPTYT HYLPPGSPTP YNPPLAGAPM PLTHL

结构预测来自 AlphaFold DB（UniProt: O60248），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

SNP variants of SOX15: Showing partial SNPs

rs1048119 rs1048131 rs17637714 rs57400259 rs67420620 rs71387972 rs71831098 rs75619393 rs78125130 rs113959665 rs140417945 rs147007422 rs182730506 rs183985449 rs186059820 rs187014451 rs190521854

Tissue expression of SOX15: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

CTACTCGACAGCCTACCTG

59

CTAGGGTCACTCTGAGGGA

59

TGCACAACTCCGAGATCTC

60

GAGGCCGGTACTTGTAGTC

60

CACAACTCCGAGATCTCCA

59

GAGGCCGGTACTTGTAGTC

60

CTACTCGACAGCCTACCTG

59

TAGGGTCACTCTGAGGGAG

59

AGAGGCTTTGGGTACAGAC

59

CAGTTTGCAGTGGGAAGAG

59

AACTCCGAGATCTCCAAGC

59

GAGGCCGGTACTTGTAGTC

60

No data available

Subcellular localization of SOX15 (and its protein):

[UniProt] [GenomeNet]

plasma membrane
cytoplasm
extracellular
golgi
vesicle
cytoskeleton
endoplasmic reticulum
nucleus
endosome
lysosome
mitochondrion

Gene Ontology (GO) terms for SOX15:

GO ID

Protein

Source DB

GO:0000122

O60248 (UniProtKB)

ISS

GO:0000981

O60248 (UniProtKB)

IEA

GO:0003677

O60248 (UniProtKB)

NAS

GO:0003682

O60248 (UniProtKB)

IEA

GO:0003700

O60248 (UniProtKB)

NAS

GO:0005515

O60248 (UniProtKB)

IPI

GO:0005515

O60248 (UniProtKB)

IPI

GO:0005634

O60248 (UniProtKB)

NAS

GO:0005737

O60248 (UniProtKB)

IEA

GO:0006325

O60248 (UniProtKB)

NAS

GO:0006355

O60248 (UniProtKB)

NAS

GO:0006357

O60248 (UniProtKB)

TAS

GO:0008584

O60248 (UniProtKB)

TAS

GO:0014718

O60248 (UniProtKB)

ISS

GO:0030154

O60248 (UniProtKB)

ISS

GO:0043403

O60248 (UniProtKB)

IEA

GO:0044798

O60248 (UniProtKB)

IEA

GO:0045843

O60248 (UniProtKB)

ISS

GO:0045944

O60248 (UniProtKB)

ISS

GO:0046982

O60248 (UniProtKB)

IEA

GO:0048627

O60248 (UniProtKB)

ISS

GO:0070318

O60248 (UniProtKB)

ISS

GO:2000288

O60248 (UniProtKB)

ISS

microRNAs potentially regulating SOX15:

String

BioGrid

IntAct

mentha

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Interacting Gene	Interaction	Source/Score

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
IGA Glomerulonephritis	0.122367032	1	1	GAD_GWASCAT
Polycystic Ovary Syndrome	0.12	1	0	CTD_human
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	0.000542884	2	0	BeFree
Malignant neoplasm of lung	0.000271442	1	0	BeFree
Colon Carcinoma	0.000271442	1	0	BeFree
Malignant tumor of colon	0.000271442	1	0	BeFree
Developmental delay (disorder)	0.000271442	1	0	BeFree
Congenital Abnormality	0.000271442	1	0	BeFree
Pancreatic Neoplasm	0.000271442	1	0	BeFree
Pancreatic carcinoma	0.000271442	1	0	BeFree

Human single-cell atlas of proliferative diabetic retinopathy reveals a SOX15-overexpressing stromal population driving retinal fibrosis through the endothelin-1 -EDNRB axis.

Tang F, He W, Niu Z, Lu H, Lin J, Lai Y, Li J, Deng W, Peng B, Wang H, Zhou Z, Chen Q, Huang S, Zhong H, Cui L, Xu F J Transl Med IF: 3.786 2026-07-22

SOX15 Contributes to the Maintenance of Pluripotency in Porcine Embryonic Stem Cells.

Jian C, Lv Y, Xu M, Wang H, Du H, Wang Y, Su M, Song J, Yan T, Liu Z Cells 2026-07-17

RNAGEN: A Generative Adversarial Network-Based Model to Generate Synthetic RNA Sequences to Target Proteins.

Ozden F, Barazandeh S, Akboga D, Tabrizi SS, Seker UOS, Cicek AE Chembiochem IF: 2.8 2026-07-14

MBD3 Knockdown Promotes the Differentiation of Bovine iPSCs into Primordial Germ Cell-like Cells Associated with Altered Bivalent Modification of TGF-β-Related Genes.

Yuan W, Wang J, Li W, Luo Y, Liu Y, Long S, Wang Y, Liu F, Geng X, Yue Y, Li X Cells 2026-08-30

Genome-wide association study of copy number variation and early growth traits in inner Mongolian cashmere goats.

Liu Y, Xi H, Xu Q, Zhou B, Li J, Su R, Lv Q, Zhang Y, Wang R, Wang Z Front Vet Sci 2025-00-00

SOX15 Transcriptionally Decreases the Level of MMP2 and Inhibits Vasculogenic Mimicry to Slow Down the Progression of Ovarian Cancer.

Zhao X, Wang X, Wang C, Tian H, Zhou Y, Gong L Biol Cell IF: 2.7 2025-08-00

HORMAD1 Polymorphisms Influence Susceptibility to Esophageal Squamous Cell Carcinoma Through Gene-Smoking Interaction.

Yue X, Yang Z, Ma J, Su Q, Pan M, Song L, Li Y, Liu S, Wu Y, Chang J Mol Carcinog IF: 3.5 2025-11-00