SOX17Gene Detail-Gene Database-Genelibs

SOX17 (SRY-box transcription factor 17)

symbol:: SOX17
locus group:: protein-coding gene
location:: 8q11.23
gene_family:: SRY (sex determining region Y)-boxes
alias symbol:: None
alias name:: None
entrez id:: 64321
ensembl gene id:: ENSG00000164736
ucsc gene id:: uc003xsb.5
refseq accession:: NM_022454
hgnc_id:: HGNC:18122
approved reserved:: 2002-02-15

8q11.23

SOX17属于SOX基因家族（SRY相关HMG-box家族），该家族成员均含有高度保守的HMG-box结构域，能够结合DNA并调控基因表达。SOX17在胚胎发育中起关键作用，尤其在原始生殖细胞、内胚层形成及心血管系统发育中不可或缺。它主要表达于内胚层来源的组织如肺、肝、胰腺和肠道，并通过调控Wnt/β-catenin等信号通路参与细胞命运决定。SOX17蛋白作为转录因子，可激活或抑制下游靶基因（如FOXA2、OCT4），其功能异常与多种疾病相关。例如，SOX17突变可能导致先天性心脏病、胆汁淤积或生殖细胞发育缺陷；在癌症中，SOX17常作为抑癌基因，其启动子甲基化或缺失与结直肠癌、肝癌的进展相关。若SOX17过表达，可能抑制肿瘤细胞增殖并促进分化，但异常高表达也可能干扰胚胎发育的时空协调性；反之，表达降低会损害内胚层器官形成，增加肿瘤侵袭风险。SOX基因家族的共性包括：通过HMG-box域以序列特异性方式结合DNA（典型靶序列为AACAAT），参与发育调控、细胞命运决定和干细胞多能性维持，且多数成员在突变后会导致发育异常或疾病。SOX17与SOX7、SOX18构成F亚家族，三者在内皮细胞功能调控中具有部分冗余性。

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OMIM entry for SOX17 Wikipedia entry for SOX17

Nucleotide sequence of SOX17:[NCBI]

Loading Gene Browser...

Protein Sequence

1MSSPDAGYAS DDQSQTQSAL PAVMAGLGPC PWAESLSPIG
41DMKVKGEAPA NSGAPAGAAG RAKGESRIRR PMNAFMVWAK
81
DERKRLAQQ NPDLHNAELS KMLGKSWKAL TLAEKRPFVE
121EAERLRVQHM QDHPNYKYRP RRRKQVKRLK RVEGGFLHGL
161A
EPQAAALG PEGGRVAMDG LGLQFPEQGF PAGPPLLPPH
201MGGHYRDCQS LGAPPLDGYP LPTPDTSPLD GVDPDPAFFA
241AP
MPGDCPA AGTYSYAQVS DYAGPPEPPA GPMHPRLGPE
281PAGPSIPGLL APPSALHVYY GAMGSPGAGG GRGFQMQPQH
321QHQ
HQHQHH PPGPGQPSPP PEALPCRDGT DPSQPAELLG
361EVDRTEFEQY LHFVCKPEMG LPYQGHDSGV NLPDSHGAIS
401SVVS
DASSA VYYCNYPDV

结构预测来自 AlphaFold DB（UniProt: Q9H6I2），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

SNP variants of SOX17: Showing partial SNPs

rs10099341 rs34741031 rs113921799 rs116016290 rs142847388 rs143403558 rs148958044 rs184628117 rs191433953 rs527568068 rs529158717 rs531249147 rs535351824 rs547224858 rs547340605 rs550305618 rs555708371

Tissue expression of SOX17: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

TGAACGCTTTCATGGTGTG

59

TGTGCAGGTCTGGATTCTG

60

GAACGCTTTCATGGTGTGG

60

TGTGCAGGTCTGGATTCTG

60

TTCATGGTGTGGGCTAAGG

60

TGTGCAGGTCTGGATTCTG

60

Transcription Factors

Target Gene

Interaction Type

PubMed References

SOX17

CSNK1A1

Repression

24407731

SOX17

FN1

Repression

24407731

SOX17

HNF4A

Activation

22068426

SOX17

MACC1

Repression

24407731

SOX17

NFAT5

Repression

24407731

SOX17

SERBP1

Repression

24407731

Subcellular localization of SOX17 (and its protein):

[UniProt] [GenomeNet]

plasma membrane
cytoplasm
extracellular
golgi
vesicle
cytoskeleton
endoplasmic reticulum
nucleus
endosome
lysosome
mitochondrion

Gene Ontology (GO) terms for SOX17:

GO ID

Protein

Source DB

GO:0000122

Q9H6I2 (UniProtKB)

IEA

GO:0001228

Q9H6I2 (UniProtKB)

IEA

GO:0001525

Q9H6I2 (UniProtKB)

ISS

GO:0001570

Q9H6I2 (UniProtKB)

ISS

GO:0001706

Q9H6I2 (UniProtKB)

IDA

GO:0001828

Q9H6I2 (UniProtKB)

IEA

GO:0001947

Q9H6I2 (UniProtKB)

ISS

GO:0001947

Q9H6I2 (UniProtKB)

ISS

GO:0003142

Q9H6I2 (UniProtKB)

ISS

GO:0003143

Q9H6I2 (UniProtKB)

ISS

GO:0003151

Q9H6I2 (UniProtKB)

ISS

GO:0003308

Q9H6I2 (UniProtKB)

IEA

GO:0003705

Q9H6I2 (UniProtKB)

ISS

GO:0003713

Q9H6I2 (UniProtKB)

IEA

GO:0005515

Q9H6I2 (UniProtKB)

IPI

GO:0005634

Q9H6I2 (UniProtKB)

IDA

GO:0005634

Q9H6I2 (UniProtKB)

IDA

GO:0005634

Q9H6I2 (UniProtKB)

IDA

GO:0005654

Q9H6I2 (UniProtKB)

TAS

GO:0005654

Q9H6I2 (UniProtKB)

TAS

GO:0005667

Q9H6I2 (UniProtKB)

IDA

GO:0006355

Q9H6I2 (UniProtKB)

ISS

GO:0007283

Q9H6I2 (UniProtKB)

IEA

GO:0007493

Q9H6I2 (UniProtKB)

IEA

GO:0008013

Q9H6I2 (UniProtKB)

IPI

GO:0008134

Q9H6I2 (UniProtKB)

IPI

GO:0008134

Q9H6I2 (UniProtKB)

IPI

GO:0021903

Q9H6I2 (UniProtKB)

IEA

GO:0023019

Q9H6I2 (UniProtKB)

IEA

GO:0030308

Q9H6I2 (UniProtKB)

IMP

GO:0031648

Q9H6I2 (UniProtKB)

IMP

GO:0035050

Q9H6I2 (UniProtKB)

ISS

GO:0042074

Q9H6I2 (UniProtKB)

IEA

GO:0042662

Q9H6I2 (UniProtKB)

IEA

GO:0042789

Q9H6I2 (UniProtKB)

IDA

GO:0043565

Q9H6I2 (UniProtKB)

IEA

GO:0044212

Q9H6I2 (UniProtKB)

ISS

GO:0044212

Q9H6I2 (UniProtKB)

ISS

GO:0044798

Q9H6I2 (UniProtKB)

IEA

GO:0045597

Q9H6I2 (UniProtKB)

IEA

GO:0045732

Q9H6I2 (UniProtKB)

IEA

GO:0045893

Q9H6I2 (UniProtKB)

ISS

GO:0045944

Q9H6I2 (UniProtKB)

IDA

GO:0045995

Q9H6I2 (UniProtKB)

ISS

GO:0046982

Q9H6I2 (UniProtKB)

IEA

GO:0048617

Q9H6I2 (UniProtKB)

ISS

GO:0048643

Q9H6I2 (UniProtKB)

IEA

GO:0048866

Q9H6I2 (UniProtKB)

IEA

GO:0050821

Q9H6I2 (UniProtKB)

IMP

GO:0060070

Q9H6I2 (UniProtKB)

IEA

GO:0060214

Q9H6I2 (UniProtKB)

ISS

GO:0060807

Q9H6I2 (UniProtKB)

ISS

GO:0060913

Q9H6I2 (UniProtKB)

IMP

GO:0060914

Q9H6I2 (UniProtKB)

TAS

GO:0060956

Q9H6I2 (UniProtKB)

ISS

GO:0061009

Q9H6I2 (UniProtKB)

IEA

GO:0061010

Q9H6I2 (UniProtKB)

IEA

GO:0061031

Q9H6I2 (UniProtKB)

ISS

GO:0072001

Q9H6I2 (UniProtKB)

IMP

GO:0072091

Q9H6I2 (UniProtKB)

IEA

GO:0090090

Q9H6I2 (UniProtKB)

IMP

GO:0090090

Q9H6I2 (UniProtKB)

IMP

GO:2000035

Q9H6I2 (UniProtKB)

IEA

GO:2000043

Q9H6I2 (UniProtKB)

IEA

microRNAs potentially regulating SOX17:

hsa-miR-125a-3p hsa-miR-125a-5p hsa-miR-141 hsa-miR-141*

String

IntAct

mentha

Loading…

Interacting Gene	Interaction	Source/Score

KEGG
Reactomepathway

Name
4310 Wnt signaling pathway [PATH:hsa04310]

Name
deactivation of the beta-catenin transactivating complex
Signaling by Wnt
TCF dependent signaling in response to WNT

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
VESICOURETERAL REFLUX 3	0.36	1	2	CLINVAR_CTD_human_UNIPROT
Colorectal Neoplasms	0.12272435	1	0	CTD_human_LHGDN
Teratogenesis	0.12	1	0	CTD_human
Cholangiocarcinoma	0.08	1	0	RGD
Intracranial Aneurysm	0.005276948	4	2	BeFree_GAD
Embryonal Carcinoma	0.002995792	2	0	BeFree_LHGDN
Lymphedema	0.002367032	1	0	GAD
Hemorrhage	0.002367032	1	0	GAD
Carcinogenesis	0.001628651	6	0	BeFree
Breast Carcinoma	0.001357209	5	0	BeFree

A Case of Prostatic Mixed Germ Cell Tumor Showing Pagetoid Spread Into the Vas Deference in a Patient With Klinefelter Syndrome.

Noto Y, Satou A, Kawano T, Fukuyama R, Miyai K, Tsuzuki T, Yanagida E Pathol Int 2026-02-00

Electrostatic properties of disordered regions control transcription factor search and pioneer activity.

Sakong S, Fierz B, Suter DM Nat Commun IF: 12.124 2026-02-08

SOX17/PAX8 dual immunohistochemical expression in the diagnosis of Müllerian carcinomas.

Moustafa M, Abdalrahman MAM, Abdelgeleel HM Diagn Pathol IF: 2.087 2026-02-10

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer.

Richey A, Kitchen N, Rush CM, Vahrenkamp JM, Abewe H, Osbourne KS, Bott AJ, Dalley BK, Rutter J, Gertz J Genome Res IF: 6.3 2026-08-12

Single-cell long- and short-read transcriptomics sheds light on high-altitude adaptation in the porcine cerebral cortex.

Chang Y, Duan B, Huo H, Zhang X, Lin W, Wen F, Guo Y, Wu L, Zou F, Huo J, Zhao G Transl Psychiatry IF: 7.5 2026-07-21

Construction and initial validation of key gene network for progesterone resistance in endometrial cancer based on genome-wide CRISPR screening.

Li X, Wang S, Qiu Z, Sun R, Wang T, Ren X, Lv B, Ma X, Cheng L, Liu Y, Jiang J Sci Rep IF: 4.9 2026-03-03

Berberine impedes the DNA damage repair to inhibit colorectal cancer by regulating the SOX17/TCF4/PIM3 axis.

Hu F, Wang W, Li M, Shi Q, Que J, Huang P Mol Genet Genomics IF: 2.2 2026-05-27

Secreted chimeric proteins as a strategy to correct SOX17 deficiency and attenuate the malignant phenotype of cholangiocarcinoma cells: a proof-of-concept study.

Peleteiro-Vigil A, Ortiz-Rivero S, Izquierdo-Mateo Y, Sanchez-Vicente L, González-Sánchez E, Vaquero J, Arevalo JC, Briz O, Monte MJ, Marin JJG, Herraez E Acta Pharmacol Sin IF: 10.4 2026-08-04

In vitro evaluation of microfluidic WS6-loaded Eudragit nanoparticles for improving insulin-producing cell differentiation.

Abuarqoub D, Mohammad M, Albarghouthi R, Abuoun M, Alnatour M, Alhawarat F, Jaradat A PLoS One IF: 2.6 None

Ability to form Sox17-induced hematopoietic cell clusters varies among distinct hematopoietic sites during development.

Itabashi A, Yokoi Y, Saito K, Tsukahara R, Melig G, Azuma K, Iizuka N, Taga T, Nobuhisa I Inflamm Regen 2026-04-23

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SOX17 (SRY-box transcription factor 17)

Gene Basic Information

Gene Basic Information

Chromosome Location

Chromosome Location

Gene Summary

Gene Summary

Gene Sequence

Gene Sequence

Encoded Protein

Encoded Protein

Gene Variants

Gene Variants

Gene Expression

Gene Expression

Gene Primers

Gene Primers

Transcription Factors

Transcription Factors

Gene Ontology

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