SRF基因详情-基因数据库-基因云馆

SRF (serum response factor)

symbol:: SRF
locus group:: protein-coding gene
location:: 6p21.1
gene_family:
alias symbol:: MCM1
alias name:: minichromosome maintenance 1 hom...
entrez id:: 6722
ensembl gene id:: ENSG00000112658
ucsc gene id:: uc003oui.4
refseq accession:: NM_003131
hgnc_id:: HGNC:11291
approved reserved:: 1995-02-10

6p21.1

SRF（血清反应因子，Serum Response Factor）是一种重要的转录因子，属于MADS-box基因家族，该家族成员通常含有保守的DNA结合结构域（MADS-box domain），参与调控细胞分化、发育和应激反应等过程。SRF主要通过结合特定的DNA序列（CArG box，序列为CC[A/T]6GG）调控靶基因的转录，其表达产物广泛存在于多种组织，尤其在肌肉、心脏和神经系统中有重要作用。SRF的核心功能是调节细胞骨架相关基因（如肌动蛋白ACTIN）和即刻早期基因（如c-FOS）的表达，从而影响细胞迁移、增殖、收缩及可塑性。在心脏中，SRF对心肌细胞的发育和功能维持至关重要；在神经元中，它参与突触可塑性和学习记忆过程。SRF的突变可能导致功能异常，例如心脏发育缺陷（如扩张型心肌病）、肌肉萎缩或神经系统功能障碍。某些癌症（如乳腺癌、胃癌）中SRF的异常高表达与肿瘤侵袭和转移相关，因其促进细胞运动性和上皮-间质转化（EMT）。若SRF表达过低，则可能引起肌肉萎缩、心脏功能减退或神经退行性病变。SRF的活性受共因子（如心肌素Myocardin家族）和信号通路（如RhoA/ROCK、MAPK）调控。其家族成员（如MEF2、MCM1）也参与细胞分化和应激响应，但各自靶基因和组织特异性不同。SRF的过表达可能激活促纤维化或促癌基因，而敲低则导致细胞骨架紊乱和凋亡增加。研究SRF有助于理解心血管疾病、神经退行性疾病及癌症的机制，并为治疗提供潜在靶点。

中文English

这个基因编码刺激既细胞增殖和分化一个无处不在的核蛋白质。它是MADS（MCM1，AGAMOUS，Deficiens和SRF）的转录因子盒超家族的成员。这种蛋白质结合在靶基因的启动子区域的血清应答元件（SRE）。该蛋白质调节的许多立即早期基因的活性，例如c-fos的，从而在细胞周期调控，细胞凋亡，细胞生长和细胞分化参与。这种基因是许多途径的下游靶标;例如，通过三元复杂的因素（TCFs中）作用在丝裂原活化蛋白激酶通路（MAPK）。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的，2014年5月提供]

OMIM数据库中对SRF基因的介绍 Wikipedia数据库中对SRF基因的介绍

SRF基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MLPTQAGAAA ALGRGSALGG SLNRTPTGRP GGGGGTRGAN
41GGRVPGNGAG LGPGRLEREA AAAAATTPAP TAGALYSGSE
81
GDSESGEEE ELGAERRGLK RSLSEMEIGM VVGGPEASAA
121ATGGYGPVSG AVSGAKPGKK TRGRVKIKME FIDNKLRRYT
161T
FSKRKTGI MKKAYELSTL TGTQVLLLVA SETGHVYTFA
201TRKLQPMITS ETGKALIQTC LNSPDSPPRS DPTTDQRMSA
241TG
FEETDLT YQVSESDSSG ETKDTLKPAF TVTNLPGTTS
281TIQTAPSTST TMQVSSGPSF PITNYLAPVS ASVSPSAVSS
321ANG
TVLKST GSGPVSSGGL MQLPTSFTLM PGGAVAQQVP
361VQAIQVHQAP QQASPSRDSS TDLTQTSSSG TVTLPATIMT
401SSVP
TTVGG HMMYPSPHAV MYAPTSGLGD GSLTVLNAFS
441QAPSTMQVSH SQVQEPGGVP QVFLTASSGT VQIPVSAVQL
481HQMAV
IGQQ AGSSSNLTEL QVVNLDTAHS TKSE

结构预测来自 AlphaFold DB（UniProt: P11831），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

SRF基因的碱基突变：仅显示部分snp

rs9395 rs3734681 rs3734682 rs6933869 rs13210208 rs41274924 rs55848540 rs78734542 rs116032487 rs137993584 rs146964345 rs181102628 rs183507239 rs184493910 rs186596236 rs189540775 rs189759968

SRF基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

TGAAGAAGGCCTATGAGCT

GTATACACATGGCCTGTCTC

CATGAAGAAGGCCTATGAGC

TACACATGGCCTGTCTCAC

TGAAGAAGGCCTATGAGCTG

TATACACATGGCCTGTCTCAC

转录因子

影响基因

影响类型

参考文献链接（PubMed）

ATF6

SRF

Unknown

9271374

ELK1

SRF

Unknown

15531578

MKL1

SRF

Unknown

14565952

NR3C1

SRF

Repression

17016446

SRF

ACTA1

Unknown

15623502

SRF

CFTR

Unknown

16170155

SRF

CREB1

Repression

1531519

SRF

DMD

Unknown

9032300

SRF

FHL2

Unknown

22456196

SRF

FOS

Activation

10742173; 9734357

SRF基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

SRF基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000790

P11831 (UniProtKB)

IEA

GO:0000978

P11831 (UniProtKB)

ISS

GO:0001076

P11831 (UniProtKB)

IEA

GO:0001077

P11831 (UniProtKB)

IDA

GO:0001228

P11831 (UniProtKB)

ISS

GO:0001569

P11831 (UniProtKB)

IEA

GO:0001666

P11831 (UniProtKB)

IEP

GO:0001707

P11831 (UniProtKB)

IEA

GO:0001764

P11831 (UniProtKB)

IEA

GO:0001829

P11831 (UniProtKB)

IDA

GO:0001947

P11831 (UniProtKB)

ISS

GO:0002011

P11831 (UniProtKB)

IEA

GO:0002042

P11831 (UniProtKB)

IMP

GO:0003257

P11831 (UniProtKB)

IGI

GO:0003700

P11831 (UniProtKB)

IDA

GO:0003705

P11831 (UniProtKB)

IEA

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005515

P11831 (UniProtKB)

IPI

GO:0005634

P11831 (UniProtKB)

IDA

GO:0005654

P11831 (UniProtKB)

TAS

GO:0005654

P11831 (UniProtKB)

TAS

GO:0005654

P11831 (UniProtKB)

TAS

GO:0005737

P11831 (UniProtKB)

TAS

GO:0006366

P11831 (UniProtKB)

IDA

GO:0007160

P11831 (UniProtKB)

IEA

GO:0007507

P11831 (UniProtKB)

ISS

GO:0007616

P11831 (UniProtKB)

IEA

GO:0008134

P11831 (UniProtKB)

IPI

GO:0008134

P11831 (UniProtKB)

IPI

GO:0008285

P11831 (UniProtKB)

IEA

GO:0008306

P11831 (UniProtKB)

IEA

GO:0009636

P11831 (UniProtKB)

TAS

GO:0009725

P11831 (UniProtKB)

IDA

GO:0010669

P11831 (UniProtKB)

IEA

GO:0010735

P11831 (UniProtKB)

IDA

GO:0010735

P11831 (UniProtKB)

IDA

GO:0010736

P11831 (UniProtKB)

IDA

GO:0021766

P11831 (UniProtKB)

IEA

GO:0022028

P11831 (UniProtKB)

IEA

GO:0030155

P11831 (UniProtKB)

IEA

GO:0030168

P11831 (UniProtKB)

IEA

GO:0030220

P11831 (UniProtKB)

IEA

GO:0030336

P11831 (UniProtKB)

IEA

GO:0030878

P11831 (UniProtKB)

IEA

GO:0031175

P11831 (UniProtKB)

IEA

GO:0031490

P11831 (UniProtKB)

IEA

GO:0033561

P11831 (UniProtKB)

IEA

GO:0034097

P11831 (UniProtKB)

IMP

GO:0034097

P11831 (UniProtKB)

NAS

GO:0035855

P11831 (UniProtKB)

IEA

GO:0035912

P11831 (UniProtKB)

IEA

GO:0042789

P11831 (UniProtKB)

ISS

GO:0042803

P11831 (UniProtKB)

IPI

GO:0042826

P11831 (UniProtKB)

IEA

GO:0043149

P11831 (UniProtKB)

IEA

GO:0043589

P11831 (UniProtKB)

IEA

GO:0045059

P11831 (UniProtKB)

IEA

GO:0045214

P11831 (UniProtKB)

IEA

GO:0045597

P11831 (UniProtKB)

IDA

GO:0045773

P11831 (UniProtKB)

IEA

GO:0045944

P11831 (UniProtKB)

IDA

GO:0045944

P11831 (UniProtKB)

IDA

GO:0045987

P11831 (UniProtKB)

IDA

GO:0046016

P11831 (UniProtKB)

IEA

GO:0046716

P11831 (UniProtKB)

ISS

GO:0048538

P11831 (UniProtKB)

IEA

GO:0048589

P11831 (UniProtKB)

IEA

GO:0048666

P11831 (UniProtKB)

TAS

GO:0048821

P11831 (UniProtKB)

IEA

GO:0051091

P11831 (UniProtKB)

IDA

GO:0051150

P11831 (UniProtKB)

TAS

GO:0051491

P11831 (UniProtKB)

IEA

GO:0055003

P11831 (UniProtKB)

IEA

GO:0060055

P11831 (UniProtKB)

TAS

GO:0060218

P11831 (UniProtKB)

IEA

GO:0060261

P11831 (UniProtKB)

IDA

GO:0060292

P11831 (UniProtKB)

IEA

GO:0060324

P11831 (UniProtKB)

IEA

GO:0060347

P11831 (UniProtKB)

IEA

GO:0060425

P11831 (UniProtKB)

IEA

GO:0060532

P11831 (UniProtKB)

IEA

GO:0060534

P11831 (UniProtKB)

IEA

GO:0060947

P11831 (UniProtKB)

IEA

GO:0061029

P11831 (UniProtKB)

IEA

GO:0061145

P11831 (UniProtKB)

IEA

GO:0070830

P11831 (UniProtKB)

IEA

GO:0070878

P11831 (UniProtKB)

ISS

GO:0071333

P11831 (UniProtKB)

IEA

GO:0090009

P11831 (UniProtKB)

IEA

GO:0090136

P11831 (UniProtKB)

IEA

GO:0090398

P11831 (UniProtKB)

IMP

GO:1900222

P11831 (UniProtKB)

IMP

GO:1902894

P11831 (UniProtKB)

ISS

GO:1902895

P11831 (UniProtKB)

ISS

GO:0000983

P11831 (UniProtKB)

IMP

可能调控 SRF基因的相关microRNA：

hsa-miR-1 hsa-miR-26b hsa-miR-122 hsa-miR-122* hsa-miR-143 hsa-miR-143* hsa-miR-145 hsa-miR-145* hsa-miR-200c hsa-miR-200c*

String

BioGrid

IntAct

mentha

MINT

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
4010 MAPK signaling pathway [PATH:hsa04010]
4022 cGMP - PKG signaling pathway [PATH:hsa04022]
5203 Viral carcinogenesis [PATH:hsa05203]
5166 HTLV-I infection [PATH:hsa05166]

名称
RHO GTPase Effectors
RHO GTPases Activate Formins
Signaling by Rho GTPases

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
HIV Infections	0.12	1	0	CTD_human
Liver carcinoma	0.081357209	6	0	BeFree_RGD
Hypertensive disease	0.08	1	0	RGD
Lymphangioleiomyomatosis	0.003267234	2	0	BeFree_LHGDN
Prostatic Neoplasms	0.002995792	2	0	BeFree_LHGDN
Alzheimer's Disease	0.002367032	1	0	GAD
Tobacco Use Disorder	0.002367032	1	0	GAD
Prostate carcinoma	0.002171535	8	1	BeFree
Malignant neoplasm of prostate	0.002171535	8	1	BeFree
Acute Megakaryocytic Leukemias	0.001628651	6	0	BeFree

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SRF (serum response factor)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

基因相关评论

联系地址

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