SRI-AS1 (SRI antisense RNA 1)

Gene Basic Information

Gene Basic Information

symbol:
SRI-AS1
locus group:
non-coding RNA
location:
7q21.12
gene_family:
None
alias symbol:
None
alias name:
None
entrez id:
102723885
ensembl gene id:
ENSG00000254003
ucsc gene id:
None
refseq accession:
NR_120517
hgnc_id:
HGNC:40564
approved reserved:
2020-03-27

Chromosome Location

Chromosome Location

7q21.12

Gene Summary

Gene Summary

SRI-AS1是一个长链非编码RNA（lncRNA）基因，位于人类第11号染色体上，靠近丝氨酸蛋白酶抑制剂（SERPINF1）基因。目前关于SRI-AS1的研究相对有限，但已知它可能通过调控邻近基因的表达或参与表观遗传修饰来发挥功能。长链非编码RNA通常不编码蛋白质，但可以调节基因表达、染色质结构和细胞信号通路。SRI-AS1可能在某些癌症中发挥作用，例如有研究表明它在肝细胞癌中可能作为肿瘤抑制因子，其低表达与较差的预后相关。如果SRI-AS1表达降低，可能导致其调控的靶基因异常表达，进而促进肿瘤发生或进展；而过表达的具体影响尚不明确，需要更多研究。SRI-AS1属于长链非编码RNA基因家族，这一家族的成员通常通过多种机制调控基因表达，包括作为竞争性内源RNA（ceRNA）吸附微小RNA（miRNA），或与蛋白质相互作用影响转录。由于lncRNA的功能高度依赖于其序列和细胞环境，SRI-AS1的具体作用机制和生物学功能仍需进一步探索。目前尚未发现它与特定遗传疾病的直接关联，但它在癌症中的潜在作用使其成为研究焦点。未来研究可能会揭示其在其他疾病或生理过程中的角色。

OMIM entry for SRI-AS1     Wikipedia entry for SRI-AS1

Gene Sequence

Gene Sequence

Nucleotide sequence of SRI-AS1:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of SRI-AS1:           Showing partial SNPs

Gene Expression

Gene Expression

Tissue expression of SRI-AS1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of SRI-AS1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for SRI-AS1:

Related microRNA

Related microRNA

microRNAs potentially regulating SRI-AS1:     

Gene Interactions

Gene Interactions

Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

Related Services

Related Services

Comments

Comments

Loading comments...

Log in to post comments Log In Sign Up

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2