TESC (tescalcin)

基因基本信息

基因基本信息

symbol:
TESC
locus group:
protein-coding gene
location:
12q24.22
gene_family:
EF-hand domain containing
alias symbol:
TSC|FLJ20607|CHP3
alias name:
calcineurin-like EF hand protein...
entrez id:
54997
ensembl gene id:
ENSG00000088992
ucsc gene id:
uc001twh.4
refseq accession:
NM_017899
hgnc_id:
HGNC:26065
approved reserved:
2006-02-07

基因染色体位置

基因染色体位置

12q24.22

基因简述

基因简述

TESC（tescalcin）基因编码一种钙离子结合蛋白，主要参与细胞信号转导和分化调控。其表达产物TESC蛋白属于EF-hand钙结合蛋白家族，该家族成员通常通过结合钙离子调节细胞内钙信号通路，影响细胞增殖、分化和凋亡等过程。TESC在心脏、肾脏、睾丸和大脑等组织中高表达，尤其在心脏发育中起关键作用，通过调节钙信号影响心肌细胞的分化和功能。TESC基因突变可能导致其钙结合能力异常，进而干扰相关信号通路，与某些心脏疾病（如心肌病）和神经系统疾病的发生有关。研究表明，TESC过表达可能促进细胞增殖并抑制分化，而降低表达则可能导致分化异常或细胞功能紊乱。在癌症中，TESC的异常表达与肿瘤进展相关，例如在结直肠癌中高表达可能促进肿瘤细胞侵袭。TESC属于tescalcin基因家族，该家族成员均含有EF-hand结构域，具有钙离子依赖性调节功能，参与多种细胞生理过程。此外，TESC与FHL2（four and a half LIM domains 2）等蛋白相互作用，共同调控ERK/MAPK信号通路，影响细胞命运决定。在胚胎发育中，TESC通过调节钙信号参与心脏形态发生，其表达异常可能导致先天性心脏缺陷。总体而言，TESC是一个重要的钙信号调节因子，其功能失衡与发育异常和疾病发生密切相关。

中文English

无

OMIM数据库中对TESC基因的介绍     Wikipedia数据库中对TESC基因的介绍

基因序列

基因序列

TESC基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MGAAHSASEE VRELEGKTGF SSDQIEQLHR RFKQLSGDQP
41TIRKENFNNV PDLELNPIRS KIVRAFFDNR NLRKGPSGLA
81 DEINFEDFL TIMSYFRPID TTMDEEQVEL SRKEKLRFLF
121HMYDSDSDGR ITLEEYRNVV EELLSGNPHI EKESARSIAD
161G AMMEAASV CMGQMEPDQV YEGITFEDFL KIWQGIDIET
201KMHVRFLNME TMALCH
结构预测来自 AlphaFold DB（UniProt: Q96BS2），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

TESC基因的碱基突变：           仅显示部分snp
rs3736417       rs7954085       rs7962894       rs7963062       rs10774903       rs11068333       rs11068334       rs11068335       rs12322125       rs34529449       rs61600841       rs73408547       rs75691232       rs76787795       rs77040520       rs78511159       rs78771296      

基因表达

基因表达

TESC基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ATCATGTCCTACTTCCGGC
59
TGTGGAACAGAAATCTCAGCT
60
AAATGTAAAGTGGTCGAGGAG
58
TTGGTCTCAATGTCGATCC
57
TTCTTCGACAACAGGAACC
58
CATGATGGTCAGGAAGTCC
58
CTGAGTTCGCTGAGTCTCC
60
ATCTGATCCGATGAGACTGG
59
GAAATGTAAAGTGGTCGAGGAG
59
TGGTCTCAATGTCGATCCC
59
ACCATCATGTCCTACTTCCG
59
GGAACAGAAATCTCAGCTTCTC
59
CTTCTTCGACAACAGGAACC
59
ATGATGGTCAGGAAGTCCTC
59
CCTGAGTTCGCTGAGTCTC
60
TCTGATCCGATGAGACTGG
58
CTGAGTTCGCTGAGTCTCC
60
TCTGATCCGATGAGACTGG
58
ATCATGTCCTACTTCCGGC
59
GGAACAGAAATCTCAGCTTCTC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

TESC基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

TESC基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000287
Q96BS2 (UniProtKB)
ISS
GO:0000287
Q96BS2 (UniProtKB)
ISS
GO:0001726
Q96BS2 (UniProtKB)
ISS
GO:0001726
Q96BS2 (UniProtKB)
ISS
GO:0004860
Q96BS2 (UniProtKB)
IEA
GO:0005509
Q96BS2 (UniProtKB)
IDA
GO:0005509
Q96BS2 (UniProtKB)
IDA
GO:0005515
Q96BS2 (UniProtKB)
IPI
GO:0005515
Q96BS2 (UniProtKB)
IPI
GO:0005515
Q96BS2 (UniProtKB)
IPI
GO:0005515
Q96BS2 (UniProtKB)
IPI
GO:0005515
Q96BS2 (UniProtKB)
IPI
GO:0005634
Q96BS2 (UniProtKB)
ISS
GO:0005634
Q96BS2 (UniProtKB)
IDA
GO:0005634
Q96BS2 (UniProtKB)
IDA
GO:0005634
Q96BS2 (UniProtKB)
IDA
GO:0005634
Q96BS2 (UniProtKB)
IDA
GO:0005737
Q96BS2 (UniProtKB)
IDA
GO:0005737
Q96BS2 (UniProtKB)
IDA
GO:0005737
Q96BS2 (UniProtKB)
IDA
GO:0005737
Q96BS2 (UniProtKB)
IDA
GO:0005886
Q96BS2 (UniProtKB)
IDA
GO:0005886
Q96BS2 (UniProtKB)
IDA
GO:0006469
Q96BS2 (UniProtKB)
IEA
GO:0008285
Q96BS2 (UniProtKB)
IMP
GO:0010628
Q96BS2 (UniProtKB)
IMP
GO:0019212
Q96BS2 (UniProtKB)
ISS
GO:0019212
Q96BS2 (UniProtKB)
ISS
GO:0030027
Q96BS2 (UniProtKB)
IDA
GO:0030154
Q96BS2 (UniProtKB)
IEA
GO:0030854
Q96BS2 (UniProtKB)
IDA
GO:0032417
Q96BS2 (UniProtKB)
IDA
GO:0032587
Q96BS2 (UniProtKB)
IEA
GO:0033628
Q96BS2 (UniProtKB)
IMP
GO:0042803
Q96BS2 (UniProtKB)
ISS
GO:0045654
Q96BS2 (UniProtKB)
IMP
GO:0045893
Q96BS2 (UniProtKB)
IMP
GO:0050821
Q96BS2 (UniProtKB)
IDA
GO:0051604
Q96BS2 (UniProtKB)
IDA
GO:0071300
Q96BS2 (UniProtKB)
IDA
GO:0072661
Q96BS2 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 TESC基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

BioGrid
IntAct
mentha
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关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Tuberous Sclerosis 0.007057489 26 0 BeFree
Hamartoma 0.001900093 7 0 BeFree
Angiomyolipoma 0.001085767 4 0 BeFree
Lymphangioleiomyomatosis 0.001085767 4 0 BeFree
Hypertensive disease 0.000814326 3 0 BeFree
Gitelman Syndrome 0.000542884 2 0 BeFree
Squamous cell carcinoma 0.000542884 2 0 BeFree
Leukemia, Myelocytic, Acute 0.000542884 2 0 BeFree
Kidney Diseases 0.000542884 2 0 BeFree
Acute leukemia 0.000542884 2 0 BeFree

基因相关文献

基因相关文献

Regulation of PDGF-BB signaling in placental pericytes by soluble PDGFRβ isoforms: implications for fetoplacental vascular development.
Barnes-Lanier AR, Duggan EC, Dunkenberger RA, Lessard CV, Cosma CC, Steele CR, Taylor SV, Darden JA, Whitham MD, Durica AR, Chappell JC Angiogenesis IF: 11.2 2026-09-03
Tescalcin is a phagocytic checkpoint driving immune escape and limiting immunotherapeutic efficacy in hepatocellular carcinoma.
Wang JL, Wang JC, Pan Y, He M, Zheng Z, Zou H, Wu T, Zhang Y, Hu Z, Fu Y, Peng W, Yang Z, Xu L, Zhang YJ, Chen MS, Hu D, Chen J, Zhao M, Chen DP, Zhou ZG J Clin Invest IF: 14.3 2026-06-01
Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state.
Gao Y, Li M, Guan W, Guo W, Wei S, Yan F, Han W, Zhang X, Yin T, Dang Y, Li H, Silva JCR, Zhang J Nat Cell Biol IF: 22.7 2025-09-00
Multimodal imaging of a tescalcin (TESC)-regulating polymorphism (rs7294919)-specific effects on hippocampal gray matter structure.
Dannlowski U, Grabe H J, Wittfeld K, Klaus J, Konrad C, Grotegerd D, Redlich R, Suslow T, Opel N, Ohrmann P, Bauer J, Zwanzger P, Laeger I, Hohoff C, Arolt V, Heindel W, Deppe M, Domschke K, Hegenscheid K, Völzke H, Stacey D, Meyer Zu Schwabedissen H, Kugel H, Baune B T Mol Psychiatry IF: 10.4 2016-03-03
Tetraploid Embryonic Stem Cells Maintain Pluripotency and Differentiation Potency into Three Germ Layers.
Imai Hiroyuki, Kano Kiyoshi, Fujii Wataru, Takasawa Ken, Wakitani Shoichi, Hiyama Masato, Nishino Koichiro, Kusakabe Ken Takeshi, Kiso Yasuo PLoS One IF: 2.6 2016-05-04
Genomic structural variants are linked with intellectual disability.
Bulayeva Kazima, Lesch Klaus-Peter, Bulayev Oleg, Walsh Christopher, Glatt Stephen, Gurgenova Farida, Omarova Jamilja, Berdichevets Irina, Thompson Paul M J Neural Transm (Vienna) IF: 4.4 2016-06-21
Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis.
Fan Jiayan, Xing Yue, Wen Xuyang, Jia Renbin, Ni Hongyan, He Jie, Ding Xia, Pan Hui, Qian Guanxiang, Ge Shengfang, Hoffman Andrew R, Zhang He, Fan Xianqun Genome Biol IF: 0.000 2016-06-01
TAPPING PILOT HOLE: MECHANICAL ANALYSIS OF SHEEP VERTEBRA AND THE ARTIFICIAL BONE MODEL.
Silva Patrícia, Rosa Rodrigo César, Shimano Antonio Carlos, de Paula Francisco José Albuquerque, Volpon José Batista, Defino Helton Luiz Aparecido Rev Bras Ortop 2016-03-29
The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer.
Kang Yun Hee, Han Seung Ro, Kim Jong-Tae, Lee Seon-Jin, Yeom Young Il, Min Jeong-Ki, Lee Chul-Ho, Kim Jae Wha, Yoon Suk Ran, Yoon Do-Young, Hong Kwan Soo, Hwang Geum-Sook, Kim Hee Cheol, Lee Young-Ha, Lee Hee Gu Oncotarget IF: 5.168 2015-01-05

基因相关服务

基因相关服务

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