TNF基因详情-基因数据库-基因云馆

TNF (tumor necrosis factor)

symbol:: TNF
locus group:: protein-coding gene
location:: 6p21.33
gene_family:: Tumor necrosis factor (ligand) superfamily
alias symbol:: TNFSF2|DIF|TNF-alpha
alias name:: TNF superfamily, member 2
entrez id:: 7124
ensembl gene id:: ENSG00000232810
ucsc gene id:: uc011fee.4
refseq accession:: NM_000594
hgnc_id:: HGNC:11892
approved reserved:: 1986-01-01

6p21.33

TNF（肿瘤坏死因子，Tumor Necrosis Factor）是一种重要的细胞因子，主要由活化的巨噬细胞、T细胞等免疫细胞产生，具有广泛的生物学功能。TNF分为TNF-α和TNF-β（又称淋巴毒素-α，Lymphotoxin-α），两者属于TNF超家族（TNF superfamily），该家族包含约19个成员，共同特点是能够通过结合特定的受体（如TNF受体家族）调控细胞存活、凋亡和炎症反应。TNF-α是研究最广泛的成员，其前体为跨膜蛋白，经酶切后释放可溶性形式。TNF-α通过结合TNFR1（广泛表达）或TNFR2（主要在免疫细胞表达）激活下游信号通路（如NF-κB和MAPK），从而调控炎症反应、免疫防御、细胞凋亡及代谢平衡。在感染或损伤时，TNF-α促进炎症以清除病原体，但过度表达会导致慢性炎症性疾病（如类风湿关节炎、克罗恩病）或脓毒症。相反，TNF-α表达不足可能削弱免疫应答，增加感染风险。基因突变（如TNF-α启动子区多态性）可能影响其表达水平，与自身免疫病或传染病易感性相关。TNF-α还参与肿瘤发生，既能杀伤肿瘤细胞，也可能通过NF-κB促进肿瘤存活。临床上，TNF抑制剂（如英夫利昔单抗）用于治疗自身免疫病，但可能增加感染或肿瘤风险。TNF家族其他成员（如FasL、TRAIL）也通过类似机制调控免疫和凋亡，但靶细胞和效应不同。TNF-α过表达会激活其他促炎因子（如IL-1、IL-6），形成“细胞因子风暴”，而抑制其表达可能减轻炎症但影响组织修复。该基因的功能复杂性使其成为免疫治疗和药物开发的关键靶点。

中文English

＜p＞人类TNF-α基因于1985年成功克隆，定位于6p21.4，长约3.6 kbp，有4个外显子和3个内含子，与主要组织相容性复合体（MHC）基因紧密连锁位于HLA-B 和 HLA-C2 位点之间的 MHC3 类基因区内，由TNFA和TNFB组成，分别编码TNFα和TNFβ。位于启动子区238位和308位存在单核苷酸多态性，被认为可调节TNF的转录水平，与慢性乙肝、自身免疫性疾病、胰岛素抵抗、肿瘤等多种疾病的易感性相关。TNF基因编码的mRNA约1.7 kbp，在其3`非翻译区有一段许多细胞因子都具有的保守TTATTTAT序列（AU富含元件，ARE）。＜/p＞＜p＞佛波酯是TNF的诱导剂，能通过靠近启动子区TATAA框的一小段序列诱导TNF的转录。＜/p＞＜p＞TNF-α和TNF-β的生物学作用极为相似，这可能与分子结构的相似性和受体的同一性有关。但在某些生物学作用方面也有不同之处。 1.1 杀伤或抑制肿瘤细胞 TNF在体内、体外均能杀死某些肿瘤细胞，或抑制增殖作用。肿瘤细胞株对TNF-α敏感性有很大的差异，TNF-α对极少数肿瘤细胞甚至有刺激作用。用放线菌素D、丝裂霉素C、放线菌酮等处理肿瘤细胞（如小鼠成纤维细胞株L929）可明显增TNF-α杀伤肿瘤细胞活性。体内肿瘤对TNF-α的反应也有很大的差异，与其体外细胞株对TNF-α的敏感性并不平行。同一细胞系可能有敏感株和抵抗株如L929-S和L929-R。此外，靶细胞内源性TNF的表达可能会使细胞抵抗外源性TNF的细胞毒作用，因此通过诱导或抑制内源性TNF的表达可改变细胞对外源性TNF的敏感性。巨噬细胞结合型TNF可能参与对靶细胞的杀伤作用。 TNF杀伤肿瘤的机理还不十分清楚，与补体或穿孔素杀伤细胞相比，TNF杀伤细胞没有穿孔现象，而且杀伤过程相对比较缓慢。TNF杀伤肿瘤组织细胞可能与以下机理有关。 1.1.1 直接杀伤或抑制作用。TNF与相应受体结合后向细胞内移，被靶细胞溶酶体摄取导致溶酶体稳定性降低，各种酶外泄，引起细胞溶解。也有认为TNF激活磷脂酶A2，释放超氧化物而引起DNA断裂，磷脂酶A2抑制剂可降低TNF的抗病效应。TNF可或改变靶细胞糖代谢，使细胞内pH降低，导致细胞死亡。 1.1.2 通过TNF对机体免疫功能的调节作用，促进T细胞及其它杀伤细胞对肿瘤细胞的杀伤。 1.1.3 TNF作用于血管内皮细胞，损伤内皮细胞或导致血管功能紊乱，使血管损伤和血栓形成，造成肿瘤组织的局部血流阻断而发生出血、缺氧坏死。 1.2 提高中性粒细胞的吞噬能力，增加过氧化物阴离子产生，增强ADCC功能，刺激细胞脱颗粒和分泌髓过氧化物酶。TNF预先与内皮细胞培养可使其增加MHCⅠ类抗原、ICAM-1的表达，IL-1、GM-CSF和IL-8的分泌，并促进中性粒细胞粘附到内皮细胞上，从而刺激机体局部炎症反应，TNF-α的这种诱导作用要比TNF-β为强。TNF刺激单核细胞和巨噬细胞分泌IL-1，并调节MHCⅡ类抗原的表达。 1.3 抗感染：如抑制疟原虫生长，抑制病毒复制（如腺病毒Ⅱ型、胞疹病毒Ⅱ型），抑制病毒蛋白合成、病毒颗粒的产生和感染性，并可杀伤病毒感染细胞。TNF抗病毒机理不十分清楚。 1.4 TNF是一种内源性热原质，引起发热，并诱导肝细胞急性期蛋白的合成。TNF引起发热可能是通过直接刺激下丘脑提问调节中枢和刺激巨噬细胞释放IL-1而引起，还可通过IL-1、TNF-α刺激其它细胞产生IL-6。 1.5 促进髓样白血病细胞向巨噬细胞分化，如促进髓样白血病细胞ML-1、单核细胞白血病细胞U937、早幼粒白血病细胞HL60的分化，机理不清楚。TGF-β可抑制TNF-α多种生物学活性，但不一致TNF-α对髓样白血病细胞分化的诱导作用，甚至还有协同效应。 1.6 促进细胞增殖和分化：TNF促进T细胞MHCⅠ类抗原表达，增强IL-2依赖的胸腺细胞、T细胞增殖能力，促进IL-2、CSF和IFN-γ等淋巴因子差生，增强有丝分裂原或外来抗原刺激B细胞的增殖和Ig分泌。TNF-α对某些肿瘤细胞具有生长因子样作用，并协同EGF、PDGF和胰岛素的促增殖作用，促进EGF受体表达。TNF也可促进c-myc和c-fos等与细胞增殖密切相关原癌基因的表达，引起细胞周期有G0期向G1期转变。最近报道TNF-β（LT）是EB病毒转化淋巴母细胞的自分泌生长因子，抗LT抗体、sTNFR以及TNF-α能一直EB病毒转化淋巴细胞的增殖。 IL-1、IFN-γ和GM-CSF对TNF的生物学作用有明显的增强作用，可能与增加细胞TNF受体的表达有关。已报道一种抗TNF-α单克隆抗体，可模拟TNF-α的某些生物学作用，这种现象在其它因子中还尚未见到。＜/p＞

OMIM数据库中对TNF基因的介绍 Wikipedia数据库中对TNF基因的介绍

TNF基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI
41VAGATTLFCL LHFGVIGPQR EEFPRDLSLI SPLAQAVRSS
81
SRTPSDKPV AHVVANPQAE GQLQWLNRRA NALLANGVEL
121RDNQLVVPSE GLYLIYSQVL FKGQGCPSTH VLLTHTISRI
161A
VSYQTKVN LLSAIKSPCQ RETPEGAEAK PWYEPIYLGG
201VFQLEKGDRL SAEINRPDYL DFAESGQVYF GIIAL

结构预测来自 AlphaFold DB（UniProt: P01375），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

TNF基因的碱基突变：仅显示部分snp

rs1799724 rs1799724 rs1799724 rs1799724 rs1799724 rs1799724 rs1799724 rs1799964 rs1799964 rs1799964 rs1799964 rs1799964 rs1799964 rs1799964 rs1800630 rs1800630 rs1800630

TNF基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

CTGCACTTTGGAGTGATCG

GAAGATGATCTGACTGCCTG

CTGCACTTTGGAGTGATCG

AAGATGATCTGACTGCCTGG

CTCTAATCAGCCCTCTGGC

GAGGGTTTGCTACAACATGG

转录因子

影响基因

影响类型

参考文献链接（PubMed）

ATF2

TNF

Activation

10688670; 10748079; 10913190; 20068037

CEBPB

TNF

Unknown

10629048; 9566900

CEBPD

TNF

Unknown

10629048

E2F1

TNF

Unknown

17707233

EGR1

TNF

Activation

10913190; 14767560

ETV4

TNF

Unknown

7896795

HDAC11

TNF

Repression

21239696

HDAC3

TNF

Unknown

15356147

HMGB2

TNF

Activation

18218727

HSF1

TNF

Unknown

18689673

TNF基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

TNF基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005164

A0A140T922 (UniProtKB)

IEA

GO:0006955

A0A140T922 (UniProtKB)

IEA

GO:0016020

A0A140T922 (UniProtKB)

IEA

GO:0000060

P01375 (UniProtKB)

IDA

GO:0000122

P01375 (UniProtKB)

IDA

GO:0000165

P01375 (UniProtKB)

IMP

GO:0000185

P01375 (UniProtKB)

IDA

GO:0000187

P01375 (UniProtKB)

IDA

GO:0001819

P01375 (UniProtKB)

IDA

GO:0001891

P01375 (UniProtKB)

ISS

GO:0001934

P01375 (UniProtKB)

IDA

GO:0001934

P01375 (UniProtKB)

IDA

GO:0001934

P01375 (UniProtKB)

IDA

GO:0002020

P01375 (UniProtKB)

IPI

GO:0002439

P01375 (UniProtKB)

IMP

GO:0002740

P01375 (UniProtKB)

IDA

GO:0002876

P01375 (UniProtKB)

IEA

GO:0002925

P01375 (UniProtKB)

IEA

GO:0005125

P01375 (UniProtKB)

IDA

GO:0005164

P01375 (UniProtKB)

IDA

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005515

P01375 (UniProtKB)

IPI

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005576

P01375 (UniProtKB)

TAS

GO:0005615

P01375 (UniProtKB)

IDA

GO:0005615

P01375 (UniProtKB)

IDA

GO:0005615

P01375 (UniProtKB)

IDA

GO:0005615

P01375 (UniProtKB)

IDA

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005886

P01375 (UniProtKB)

TAS

GO:0005887

P01375 (UniProtKB)

IDA

GO:0006006

P01375 (UniProtKB)

IEA

GO:0006919

P01375 (UniProtKB)

IDA

GO:0006927

P01375 (UniProtKB)

IDA

GO:0006954

P01375 (UniProtKB)

IDA

GO:0006954

P01375 (UniProtKB)

IDA

GO:0006954

P01375 (UniProtKB)

IDA

GO:0006959

P01375 (UniProtKB)

IEA

GO:0007249

P01375 (UniProtKB)

TAS

GO:0007254

P01375 (UniProtKB)

IEA

GO:0008625

P01375 (UniProtKB)

IDA

GO:0008625

P01375 (UniProtKB)

IDA

GO:0008625

P01375 (UniProtKB)

IDA

GO:0008625

P01375 (UniProtKB)

NAS

GO:0008630

P01375 (UniProtKB)

IEA

GO:0009615

P01375 (UniProtKB)

IDA

GO:0009651

P01375 (UniProtKB)

TAS

GO:0009897

P01375 (UniProtKB)

ISS

GO:0009986

P01375 (UniProtKB)

IDA

GO:0010628

P01375 (UniProtKB)

IMP

GO:0010628

P01375 (UniProtKB)

IDA

GO:0010628

P01375 (UniProtKB)

IDA

GO:0010628

P01375 (UniProtKB)

IDA

GO:0010628

P01375 (UniProtKB)

IDA

GO:0010628

P01375 (UniProtKB)

IDA

GO:0010628

P01375 (UniProtKB)

IMP

GO:0010628

P01375 (UniProtKB)

IDA

GO:0010628

P01375 (UniProtKB)

IDA

GO:0010629

P01375 (UniProtKB)

IDA

GO:0010629

P01375 (UniProtKB)

IDA

GO:0010693

P01375 (UniProtKB)

IEA

GO:0010803

P01375 (UniProtKB)

TAS

GO:0010888

P01375 (UniProtKB)

NAS

GO:0030198

P01375 (UniProtKB)

IEA

GO:0030316

P01375 (UniProtKB)

IEA

GO:0030730

P01375 (UniProtKB)

IDA

GO:0030866

P01375 (UniProtKB)

IDA

GO:0031334

P01375 (UniProtKB)

IDA

GO:0031622

P01375 (UniProtKB)

ISS

GO:0031663

P01375 (UniProtKB)

IDA

GO:0032715

P01375 (UniProtKB)

IDA

GO:0032722

P01375 (UniProtKB)

IDA

GO:0032729

P01375 (UniProtKB)

IEA

GO:0032755

P01375 (UniProtKB)

IEA

GO:0032757

P01375 (UniProtKB)

IMP

GO:0032800

P01375 (UniProtKB)

IDA

GO:0033138

P01375 (UniProtKB)

IDA

GO:0033138

P01375 (UniProtKB)

IDA

GO:0033209

P01375 (UniProtKB)

IMP

GO:0033209

P01375 (UniProtKB)

TAS

GO:0033209

P01375 (UniProtKB)

TAS

GO:0034116

P01375 (UniProtKB)

IDA

GO:0034116

P01375 (UniProtKB)

IDA

GO:0035509

P01375 (UniProtKB)

IDA

GO:0042346

P01375 (UniProtKB)

IDA

GO:0042802

P01375 (UniProtKB)

IDA

GO:0043065

P01375 (UniProtKB)

IDA

GO:0043065

P01375 (UniProtKB)

IDA

GO:0043065

P01375 (UniProtKB)

IDA

GO:0043065

P01375 (UniProtKB)

IMP

GO:0043068

P01375 (UniProtKB)

IDA

GO:0043122

P01375 (UniProtKB)

IDA

GO:0043123

P01375 (UniProtKB)

IDA

GO:0043123

P01375 (UniProtKB)

IDA

GO:0043242

P01375 (UniProtKB)

IDA

GO:0043243

P01375 (UniProtKB)

IDA

GO:0043243

P01375 (UniProtKB)

IDA

GO:0043280

P01375 (UniProtKB)

IDA

GO:0043406

P01375 (UniProtKB)

IDA

GO:0043406

P01375 (UniProtKB)

IDA

GO:0043406

P01375 (UniProtKB)

IDA

GO:0043491

P01375 (UniProtKB)

IMP

GO:0043507

P01375 (UniProtKB)

IDA

GO:0044130

P01375 (UniProtKB)

IEA

GO:0044212

P01375 (UniProtKB)

IDA

GO:0045071

P01375 (UniProtKB)

IDA

GO:0045080

P01375 (UniProtKB)

IDA

GO:0045121

P01375 (UniProtKB)

IDA

GO:0045416

P01375 (UniProtKB)

IDA

GO:0045429

P01375 (UniProtKB)

IDA

GO:0045599

P01375 (UniProtKB)

NAS

GO:0045662

P01375 (UniProtKB)

IEA

GO:0045668

P01375 (UniProtKB)

IEA

GO:0045672

P01375 (UniProtKB)

IDA

GO:0045785

P01375 (UniProtKB)

IMP

GO:0045860

P01375 (UniProtKB)

IDA

GO:0045892

P01375 (UniProtKB)

IDA

GO:0045892

P01375 (UniProtKB)

IDA

GO:0045893

P01375 (UniProtKB)

IDA

GO:0045893

P01375 (UniProtKB)

IDA

GO:0045893

P01375 (UniProtKB)

IDA

GO:0045944

P01375 (UniProtKB)

IDA

GO:0045944

P01375 (UniProtKB)

IGI

GO:0045944

P01375 (UniProtKB)

IDA

GO:0045994

P01375 (UniProtKB)

IEA

GO:0046325

P01375 (UniProtKB)

IEA

GO:0048566

P01375 (UniProtKB)

IEP

GO:0048661

P01375 (UniProtKB)

IDA

GO:0050715

P01375 (UniProtKB)

IDA

GO:0050766

P01375 (UniProtKB)

IMP

GO:0050796

P01375 (UniProtKB)

IDA

GO:0050830

P01375 (UniProtKB)

IEA

GO:0050901

P01375 (UniProtKB)

IDA

GO:0050995

P01375 (UniProtKB)

IDA

GO:0051023

P01375 (UniProtKB)

IEA

GO:0051044

P01375 (UniProtKB)

IDA

GO:0051091

P01375 (UniProtKB)

IDA

GO:0051092

P01375 (UniProtKB)

IDA

GO:0051092

P01375 (UniProtKB)

IDA

GO:0051092

P01375 (UniProtKB)

IDA

GO:0051092

P01375 (UniProtKB)

IDA

GO:0051092

P01375 (UniProtKB)

IDA

GO:0051092

P01375 (UniProtKB)

IDA

GO:0051092

P01375 (UniProtKB)

IDA

GO:0051092

P01375 (UniProtKB)

IMP

GO:0051222

P01375 (UniProtKB)

IDA

GO:0051384

P01375 (UniProtKB)

IDA

GO:0051533

P01375 (UniProtKB)

IDA

GO:0051798

P01375 (UniProtKB)

IEA

GO:0051897

P01375 (UniProtKB)

IEA

GO:0055037

P01375 (UniProtKB)

ISS

GO:0060557

P01375 (UniProtKB)

IDA

GO:0060559

P01375 (UniProtKB)

IDA

GO:0060664

P01375 (UniProtKB)

IEA

GO:0060693

P01375 (UniProtKB)

IEA

GO:0061048

P01375 (UniProtKB)

IDA

GO:0070374

P01375 (UniProtKB)

NAS

GO:0071230

P01375 (UniProtKB)

IEA

GO:0071316

P01375 (UniProtKB)

IDA

GO:0071407

P01375 (UniProtKB)

IDA

GO:0071550

P01375 (UniProtKB)

TAS

GO:0071677

P01375 (UniProtKB)

NAS

GO:0071803

P01375 (UniProtKB)

IDA

GO:0090002

P01375 (UniProtKB)

IDA

GO:0097191

P01375 (UniProtKB)

IDA

GO:0097191

P01375 (UniProtKB)

IDA

GO:0097527

P01375 (UniProtKB)

IDA

GO:0097527

P01375 (UniProtKB)

IDA

GO:0097527

P01375 (UniProtKB)

IDA

GO:0097527

P01375 (UniProtKB)

IDA

GO:1901224

P01375 (UniProtKB)

IDA

GO:1901671

P01375 (UniProtKB)

IDA

GO:1903140

P01375 (UniProtKB)

IDA

GO:1903347

P01375 (UniProtKB)

IDA

GO:1904999

P01375 (UniProtKB)

IDA

GO:2000010

P01375 (UniProtKB)

IDA

GO:2000304

P01375 (UniProtKB)

TAS

GO:2000334

P01375 (UniProtKB)

IDA

GO:2000343

P01375 (UniProtKB)

IDA

GO:2001240

P01375 (UniProtKB)

IDA

GO:2001240

P01375 (UniProtKB)

IDA

可能调控 TNF基因的相关microRNA：

hsa-let-7a hsa-let-7b hsa-let-7b* hsa-let-7c hsa-let-7c* hsa-let-7d hsa-let-7d* hsa-let-7e hsa-let-7e* hsa-let-7f

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
4010 MAPK signaling pathway [PATH:hsa04010]
4350 TGF-beta signaling pathway [PATH:hsa04350]
4064 NF-kappa B signaling pathway [PATH:hsa04064]
4668 TNF signaling pathway [PATH:hsa04668]
4071 Sphingolipid signaling pathway [PATH:hsa04071]
4150 mTOR signaling pathway [PATH:hsa04150]
4060 Cytokine-cytokine receptor interaction [PATH:hsa04060]
4210 Apoptosis [PATH:hsa04210]
4640 Hematopoietic cell lineage [PATH:hsa04640]
4620 Toll-like receptor signaling pathway [PATH:hsa04620]
4621 NOD-like receptor signaling pathway [PATH:hsa04621]
4622 RIG-I-like receptor signaling pathway [PATH:hsa04622]
4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650]
4612 Antigen processing and presentation [PATH:hsa04612]
4660 T cell receptor signaling pathway [PATH:hsa04660]
4664 Fc epsilon RI signaling pathway [PATH:hsa04664]
4920 Adipocytokine signaling pathway [PATH:hsa04920]
4380 Osteoclast differentiation [PATH:hsa04380]
5205 Proteoglycans in cancer [PATH:hsa05205]
5310 Asthma [PATH:hsa05310]
5322 Systemic lupus erythematosus [PATH:hsa05322]
5323 Rheumatoid arthritis [PATH:hsa05323]
5321 Inflammatiory bowel disease (IBD) [PATH:hsa05321]
5330 Allograft rejection [PATH:hsa05330]
5332 Graft-versus-host disease [PATH:hsa05332]
5010 Alzheimer's disease [PATH:hsa05010]
5014 Amyotrophic lateral sclerosis (ALS) [PATH:hsa05014]
5410 Hypertrophic cardiomyopathy (HCM) [PATH:hsa05410]
5414 Dilated cardiomyopathy (DCM) [PATH:hsa05414]
4940 Type I diabetes mellitus [PATH:hsa04940]
4930 Type II diabetes mellitus [PATH:hsa04930]
4932 Non-alcoholic fatty liver disease (NAFLD) [PATH:hsa04932]
5133 Pertussis [PATH:hsa05133]
5134 Legionellosis [PATH:hsa05134]
5152 Tuberculosis [PATH:hsa05152]
5166 HTLV-I infection [PATH:hsa05166]
5164 Influenza A [PATH:hsa05164]
5161 Hepatitis B [PATH:hsa05161]
5160 Hepatitis C [PATH:hsa05160]
5168 Herpes simplex infection [PATH:hsa05168]
5146 Amoebiasis [PATH:hsa05146]
5144 Malaria [PATH:hsa05144]
5145 Toxoplasmosis [PATH:hsa05145]
5140 Leishmaniasis [PATH:hsa05140]
5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142]
5143 African trypanosomiasis [PATH:hsa05143]

名称
Death Receptor Signalling
Developmental Biology
TNF signaling
TNFR1-mediated proapoptotic signaling
Transcriptional regulation of white adipocyte differentiation

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Rheumatoid Arthritis	0.425384406	520	8	BeFree_CTD_human_GAD_LHGDN_MGD
Crohn Disease	0.422294957	114	23	BeFree_CTD_human_GAD_GWASCAT_LHGDN_RGD
Diabetes Mellitus, Non-Insulin-Dependent	0.316412937	115	8	BeFree_CTD_human_GAD_LHGDN_RGD
Sepsis	0.286154284	101	2	BeFree_CTD_human_GAD_LHGDN_RGD
Asthma	0.265827974	123	14	BeFree_CTD_human_GAD_LHGDN
Cerebrovascular accident	0.251179214	36	0	BeFree_CTD_human_GAD_LHGDN_RGD
Myocardial Infarction	0.248293042	30	0	BeFree_CTD_human_GAD_LHGDN_RGD
Hypertensive disease	0.239824805	32	0	BeFree_CTD_human_GAD_LHGDN_RGD
Obesity	0.237471127	164	3	BeFree_CTD_human_GAD
Insulin Resistance	0.230771416	16	0	CTD_human_GAD_RGD

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