UBE2L3基因详情-基因数据库-基因云馆

UBE2L3 (ubiquitin conjugating enzyme E2 L3)

symbol:: UBE2L3
locus group:: protein-coding gene
location:: 22q11.21
gene_family:: Ubiquitin-conjugating enzymes E2
alias symbol:: UBCH7
alias name:: None
entrez id:: 7332
ensembl gene id:: ENSG00000185651
ucsc gene id:: uc002zva.2
refseq accession:: NM_198157
hgnc_id:: HGNC:12488
approved reserved:: 1997-03-21

22q11.21

UBE2L3（Ubiquitin-Conjugating Enzyme E2 L3）是一种泛素结合酶，属于E2泛素偶联酶家族。该基因编码的蛋白质参与泛素-蛋白酶体系统（UPS），负责将泛素分子转移到靶蛋白上，从而调控蛋白质的降解、信号传导和细胞周期等过程。UBE2L3主要在细胞质和细胞核中表达，其功能依赖于与E3泛素连接酶的相互作用，共同完成特定底物的泛素化修饰。UBE2L3的突变或表达异常可能导致泛素化过程紊乱，进而影响细胞稳态。例如，UBE2L3的某些变异与自身免疫性疾病（如系统性红斑狼疮、类风湿性关节炎）和癌症（如淋巴瘤）的发生有关。研究发现，UBE2L3的过表达可能增强NF-κB等炎症相关信号通路的活性，促进炎症反应或肿瘤发展；而表达降低则可能削弱蛋白质降解效率，导致异常蛋白积累，引发细胞功能障碍。UBE2L3所属的E2泛素偶联酶家族成员均含有保守的泛素结合域（UBC域），负责泛素分子的转移，但不同成员具有底物特异性和功能多样性。该基因的调控异常可能通过影响其他泛素化相关基因（如E3连接酶）或下游信号分子（如IKK复合物）的功能，进一步放大生物学效应。目前针对UBE2L3的研究有助于理解泛素化在疾病中的作用，并为相关治疗提供潜在靶点。

中文English

与泛素蛋白的修饰是降解目标异常或短命的蛋白质一种重要的细胞机制。泛素化涉及至少三类酶：泛素活化酶（个E1），泛素结合酶（E2S）和泛素 - 蛋白连接酶（E3酶）。这个基因编码的E2泛素结合酶家族的一个成员。这种酶被证明参与p53的泛素化和c-Fos蛋白，并在体外NF-κB的前体P105。几个可变剪接转录变异体也发现了这种基因。 [由RefSeq的，2009年09月提供]

OMIM数据库中对UBE2L3基因的介绍 Wikipedia数据库中对UBE2L3基因的介绍

UBE2L3基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV
41PDNPPYDKGA FRIEINFPAE YPFKPPKITF KTKIYHPNID
81
EKGQVCLPV ISAENWKPAT KTDQVIQSLI ALVNDPQPEH
121PLRADLAEEY SKDRKKFCKN AEEFTKKYGE KRPVD

结构预测来自 AlphaFold DB（UniProt: P68036），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

UBE2L3基因的碱基突变：仅显示部分snp

rs531885672 rs532484714 rs534250205 rs539159280 rs540602541 rs546974300 rs548514869 rs552679411 rs556434496 rs560497127 rs562936043 rs568387514 rs570155435 rs571546862 rs572385159 rs7444 rs7445

UBE2L3基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GCTGATGAAGGACAACCCT

60

GGTTTGAATGGGTACTCTGC

59

ACCGACCAAGTAATCCAGTC

59

ATTCTTCAGCTAGGTCAGCC

59

GTCAGTTTGTTGGTGGGTC

59

GGATTTCTTCAAGCTCCCG

59

AGGAGCTTGAAGAAATCCG

58

CATATGGAGGGTTGTCAGG

57

TCGATCTGCTTGTCCTTGG

60

TTTCTTCAAGCTCCTCCGG

60

GTCAGTTTGTTGGTGGGTC

59

GATTTCTTCAAGCTCCCGC

59

GGAGCTTGAAGAAATCCGC

59

CATATGGAGGGTTGTCAGGA

59

CGACCAAGTAATCCAGTCC

57

GTATTCTTCAGCTAGGTCAGC

58

CAAAGACTTGGCACAGCTC

60

CGGATTTCTTCAAGCTCCTC

59

TGATGAAGGACAACCCTCC

59

GTGGTTTGAATGGGTACTCTG

59

尚未收录相关数据

UBE2L3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

UBE2L3基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000151

P68036 (UniProtKB)

TAS

GO:0000209

P68036 (UniProtKB)

IDA

GO:0000209

P68036 (UniProtKB)

IDA

GO:0003713

P68036 (UniProtKB)

IDA

GO:0004842

P68036 (UniProtKB)

IMP

GO:0004842

P68036 (UniProtKB)

IDA

GO:0004842

P68036 (UniProtKB)

IDA

GO:0004842

P68036 (UniProtKB)

IDA

GO:0004842

P68036 (UniProtKB)

TAS

GO:0004842

P68036 (UniProtKB)

TAS

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005515

P68036 (UniProtKB)

IPI

GO:0005524

P68036 (UniProtKB)

IEA

GO:0005634

P68036 (UniProtKB)

IDA

GO:0005634

P68036 (UniProtKB)

IDA

GO:0005634

P68036 (UniProtKB)

IDA

GO:0005737

P68036 (UniProtKB)

IDA

GO:0005737

P68036 (UniProtKB)

IDA

GO:0005737

P68036 (UniProtKB)

IDA

GO:0005737

P68036 (UniProtKB)

IDA

GO:0006351

P68036 (UniProtKB)

IEA

GO:0006355

P68036 (UniProtKB)

IMP

GO:0006355

P68036 (UniProtKB)

IDA

GO:0006464

P68036 (UniProtKB)

TAS

GO:0006511

P68036 (UniProtKB)

TAS

GO:0006511

P68036 (UniProtKB)

TAS

GO:0008283

P68036 (UniProtKB)

IMP

GO:0016567

P68036 (UniProtKB)

IDA

GO:0016567

P68036 (UniProtKB)

IDA

GO:0019899

P68036 (UniProtKB)

TAS

GO:0031398

P68036 (UniProtKB)

IGI

GO:0031625

P68036 (UniProtKB)

IPI

GO:0031625

P68036 (UniProtKB)

IPI

GO:0031625

P68036 (UniProtKB)

IPI

GO:0031625

P68036 (UniProtKB)

IPI

GO:0042787

P68036 (UniProtKB)

IEA

GO:0044770

P68036 (UniProtKB)

IMP

GO:0044822

P68036 (UniProtKB)

IDA

GO:0051443

P68036 (UniProtKB)

IGI

GO:0061631

P68036 (UniProtKB)

IDA

GO:0070062

P68036 (UniProtKB)

IDA

GO:0070979

P68036 (UniProtKB)

IDA

GO:0071383

P68036 (UniProtKB)

IMP

GO:0071385

P68036 (UniProtKB)

IDA

GO:0097027

P68036 (UniProtKB)

IGI

GO:1903955

P68036 (UniProtKB)

IMP

可能调控 UBE2L3基因的相关microRNA：

hsa-miR-122 hsa-miR-423-5p hsa-miR-93

String

BioGrid

IntAct

mentha

MINT

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
4120 Ubiquitin mediated proteolysis [PATH:hsa04120]
5012 Parkinson's disease [PATH:hsa05012]

名称
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Lupus Erythematosus, Systemic	0.126362715	8	1	BeFree_GAD_GWASCAT
Crohn Disease	0.125005506	2	1	BeFree_GAD_GWASCAT
Hepatitis B	0.120271442	1	1	BeFree_GWASCAT
Inflammatory Bowel Diseases	0.12	1	1	GWASCAT
Hepatitis B, Chronic	0.12	1	0	CTD_human
Autoimmune Diseases	0.002909916	3	0	BeFree_GAD
Celiac Disease	0.002367032	1	1	GAD
Malignant neoplasm of prostate	0.000542884	2	0	BeFree
Rheumatoid Arthritis	0.000542884	2	0	BeFree
Ulcerative Colitis	0.000542884	2	3	BeFree

In vivo CRISPR/Cas9 Screening Reveals that UBE2L3 Modulates Autophagic Flux through TSC2 Ubiquitination and Potentiates PD-1 Blockade in Triple-Negative Breast Cancer.

Xu J, Cheng L, Ma S, Gan C, Chai J, Zheng X, Hu L, Ling M, Zhang M, Zhao B, Cheng H Int J Biol Sci IF: 11.7 None

Transcriptome sequencing (RNA-Seq) reveals non-coding pseudogene CDC27P9 role in cervical cancer.

Antony Edwin Rodrigues F, Krishnan D, Abbas HH, Raj MJM, Subramani S, Lakshman N, Justin A, Govindaraj S, Ramasamy S Apoptosis IF: 9.0 2026-03-24

Isobaric quantitative proteomics reveals altered extracellular matrix, cytoskeletal, and degradation pathways in glaucomatous trabecular meshwork cells.

Holden P, Sun YY, Zientek K, Wilmarth PA, Reddy AP, Keller KE Sci Rep IF: 4.9 2026-03-18

E2 variants for probing E3 ubiquitin ligase activities.

Du J, Andree GA, Horn-Ghetko D, Stier L, Singh J, Kostrhon S, Kiss L, Mann M, Sidhu SS, Schulman BA Proc Natl Acad Sci U S A IF: 9.5 2026-01-06

Ivangustin, a sesquiterpene lactone from Inula japonica Thunb., attenuates neuroinflammation through covalent inhibition of ubiquitin-conjugating enzyme UBE2L3.

Qiao M, Gan H, Shi Y, Yang S, Liu T, Shen X, Wu W Chin Med IF: 7.4 2026-09-02

Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes.

Hu B, Zhang M, Yu Y, Liu Y, Wang J, Zhang A, Li Q, Gao Y, Li Z, Bian L, Gu Y, Zhu X, She Q, Gao X, Deng B, Fang H, Hu C, Chen Y, Chen Y, Wang X, Yin X, Zhu M, Wang L, Jiang Y, Chen J, Dai J, Ma H, Ding Y, Yan C, Jin G Am J Hum Genet IF: 7.7 2026-07-02

Degradation of voltage-gated calcium channels: mechanisms and applications in neurological and cardiovascular diseases.

Liu L, Zhou Y, Liao P, Soong TW, Hu Z Cell Commun Signal IF: 3.943 2025-07-14

Immunoregulatory Microenvironment in the Elderly Skin.

Shimizu Y, Koguchi-Yoshioka H, Kubo T, Matsumura Y, Matsuda S, Tanemura A, Nomori M, Otani N, Taminato M, Tomita K, Kubo T, Fujimoto M, Watanabe R JID Innov 2025-11-00

Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus.

Zhang Yan, Wang Yong-Fei, Yang Jing, Zhang Jing, Sun Liangdan, Hirankarn Nattiya, Pan Hai-Feng, Lau Chak Sing, Chan Tak Mao, Lee Tsz Leung, Leung Alexander Moon Ho, Mok Chi Chiu, Zhang Lu, Shen Jiangshan Jane, Wong Sik Nin, Lee Ka Wing, Ho Marco Hok Kung, Lee Pamela Pui Wah, Chung Brian Hon-Yin, Chong Chun Yin, Wong Raymond Woon Sing, Mok Mo Yin, Wong Wilfred Hing Sang, Tong Kwok Lung, Tse Niko Kei Chiu, Li Xiang-Pei, Avihingsanon Yingyos, Rianthavorn Pornpimol, Deekajorndej Thavatchai, Suphapeetiporn Kanya, Shotelersuk Vorasuk, Ying Shirley King Yee, Fung Samuel Ka Shun, Lai Wai Ming, Wong Chun-Ming, Ng Irene Oi Lin, Garcia-Barcelo Maria-Merce, Cherny Stacey S, Tam Paul Kwong-Hang, Sham Pak Chung, Yang Sen, Ye Dong Qing, Cui Yong, Zhang Xue-Jun, Yang Wanling, Lau Yu Lung Arthritis Res Ther IF: 5.4 2016-04-08

Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans.

Ye Byong Duk, Choi Hyunchul, Hong Myunghee, Yun Woo Jin, Low Hui-Qi, Haritunians Talin, Kim Kyung-Jo, Park Sang Hyoung, Lee Inchul, Bang So-Young, Kim Tae-Hwan, Shin Hyoung Doo, Kang Daehee, Youn Hee-Shang, Li Yi, Liu Jianjun, McGovern Dermot P B, Yang Suk-Kyun, Song Kyuyoung Inflamm Bowel Dis IF: 5.5 2016-10-18

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UBE2L3 (ubiquitin conjugating enzyme E2 L3)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

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