VIM-AS1Gene Detail-Gene Database-Genelibs

VIM-AS1 (VIM antisense RNA 1)

symbol

VIM-AS1

locus group

non-coding RNA

location

10p13

gene_family

alias symbol

alias name

None

entrez id

100507347

ensembl gene id

ENSG00000229124

ucsc gene id

uc001iot.3

refseq accession

NR_108061

hgnc_id

HGNC:44879

approved reserved

2012-12-11

10p13

VIM-AS1是一个长链非编码RNA（lncRNA）基因，位于人类17号染色体上，与波形蛋白（Vimentin，VIM）基因相邻。它属于长链非编码RNA家族，这类RNA通常不编码蛋白质，但参与调控基因表达、染色质修饰和细胞信号传导等过程。VIM-AS1的主要功能是通过顺式或反式作用调控邻近的VIM基因或其他相关基因的表达。VIM基因编码的波形蛋白是一种中间纤维蛋白，主要在间充质细胞中表达，参与细胞骨架的形成、细胞迁移和伤口愈合等生物学过程。VIM-AS1可能通过影响VIM的表达来调节这些功能。目前关于VIM-AS1突变的研究较少，但lncRNA的突变通常会影响其与蛋白质或DNA/RNA的相互作用，从而干扰其调控功能。VIM-AS1与多种疾病相关，特别是在癌症中，它的异常表达可能通过调控上皮-间质转化（EMT）过程促进肿瘤的侵袭和转移。例如，在某些癌症中，VIM-AS1的过表达可能上调VIM，增强肿瘤细胞的迁移能力，而降低其表达可能抑制肿瘤进展。VIM-AS1属于lncRNA家族，该家族的成员通常具有组织特异性表达模式，并参与复杂的基因调控网络。由于lncRNA的功能多样性，VIM-AS1可能还与其他基因或信号通路相互作用，但其具体机制仍需进一步研究。

OMIM entry for VIM-AS1 Wikipedia entry for VIM-AS1

Nucleotide sequence of VIM-AS1:[NCBI]

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SNP variants of VIM-AS1: Showing partial SNPs

rs151766 rs1042003 rs1470379 rs1899900 rs3758410 rs3758411 rs3758412 rs3758413 rs5783537 rs6602186 rs7068746 rs7081155 rs7083383 rs7096062 rs7097288 rs7902710 rs7903137

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

GTCCTCTTCATCATCTCAGGG

CTTTGCTGTCATGGGACTG

AGAAGCCTTCGATGTGAGG

AATTGTTCAGATGCCAAGGC

AAGAAGCCTTCGATGTGAG

ATTGTTCAGATGCCAAGGC

TCCTCTTCATCATCTCAGGG

CTTTGCTGTCATGGGACTG

AGAAGCCTTCGATGTGAGG

ATTGTTCAGATGCCAAGGC

CCTCTTCATCATCTCAGGGA

CTTTGCTGTCATGGGACTG

The long noncoding RNA VIM-AS1 and nucleoporin Nup358/RanBP2 regulate SMAD nuclear accumulation during TGF-β signaling.

Rodrigues-Junior DM, Ali MM, Itoh Y, Ferreira MS, Heldin J, Fu H, Hoelz A, Heldin CH, Moustakas A Nucleic Acids Res IF: 15.0 2026-01-14

LncRNA-mRNA regulatory network reveals key lncRNAs tightly associated with preterm labor and premature rupture of membranes.

Yang G, Qi W Noncoding RNA Res IF: 5.6 2025-04-00

Long Noncoding VIM-AS1: Biomarker of Breast Fibrosis Susceptibility After Radiation Therapy and Promoter of Transforming Growth Factor Beta1-Driven Fibrosis.

Vinasco-Sandoval T, Moratille S, Crechet F, Mesloub Y, Montanari J, Auvré F, Deleuze JF, Foray N, Fortunel NO, Martin MT Int J Radiat Oncol Biol Phys IF: 7.4 2025-03-01

Characterizing hub biomarkers for metabolic-induced endothelial dysfunction and unveiling their regulatory roles in EndMT through RNA sequencing and machine learning approaches.

Sun Q, Xie L, An H, Chen W, Yang Q, Wang P, Tang Y, Peng C Front Cardiovasc Med IF: 3.0 2025-00-00

Extracellular vesicle-derived lncRNA VIM-AS1 promotes diabetic wound healing by promoting glycolysis and alleviating cellular senescence.

Liang F, Huang N, Tian Y, Fang Y, Huang C, Qiu B, Lu T, Zheng L, Cheng J, Zhu B, Zhao J Stem Cell Res Ther IF: 4.211 2025-07-01

Yiqi Yangyin Tongluo prescription targets lncRNA VIM-AS1 to regulate FOXK2/mTOR to promote autophagy and inhibit renal tubular epithelial cell apoptosis.

Yu R, Wu R, Chen T, Xu J J Food Drug Anal 2025-06-13

Development of a senescence-related lncRNA signature in endometrial cancer based on multiple machine learning models.

Lin J, Lei X, Li Y, Jiang X, Jiang F, Guo A, Cai X, Ye X, Sun Y Front Genet IF: 2.8 2025-00-00

LncRNA VIM-AS1 is a potential prognostic biomarker and effects on tumor cellular behaviors in breast cancer via impairing miR-29a-3p.

Yuan Y, Wei M, Kong L, Li P, Zhang H, Bian W, Yuan Q Discov Oncol 2025-10-03

Single-cell profiling and functional screening reveal crucial roles for lncRNAs in the epidermal re-epithelialization of human acute wounds.

Xiao Y, Zhang C, Liu X, Yang Y, Landén NX, Zhang Z, Li D Front Surg IF: 1.9 2024-00-00