ZFX-AS1 (ZFX antisense RNA 1)

Gene Basic Information

Gene Basic Information

symbol
ZFX-AS1
locus group
non-coding RNA
location
Xp22.11
gene_family
-
alias symbol
-
alias name
None
entrez id
100873922
ensembl gene id
ENSG00000234230
ucsc gene id
uc031thb.1
refseq accession
NR_046657
hgnc_id
HGNC:40617
approved reserved
2011-07-29

Chromosome Location

Chromosome Location

Xp22.11

Gene Summary

Gene Summary

ZFX-AS1是一个长链非编码RNA（lncRNA）基因，位于X染色体上，与ZFX基因的反义链重叠。ZFX-AS1通过调控ZFX基因的表达或其他机制参与多种生物学过程。ZFX基因属于锌指蛋白家族，该家族成员通常含有锌指结构域，能够结合DNA或RNA，参与转录调控、细胞分化等过程。ZFX-AS1作为反义lncRNA，可能通过顺式或反式作用调控ZFX的表达，影响其下游靶基因。研究表明，ZFX-AS1在多种癌症中异常表达，如肝细胞癌、胃癌等，其过表达可能促进肿瘤细胞增殖、迁移和侵袭，而降低表达则可能抑制这些恶性表型。ZFX-AS1的异常表达可能通过调控细胞周期、凋亡或上皮-间质转化（EMT）等途径影响肿瘤进展。此外，ZFX-AS1可能作为竞争性内源RNA（ceRNA）吸附miRNA，间接调控其他基因的表达。突变或表观遗传修饰可能导致ZFX-AS1表达异常，进而影响ZFX或其他相关基因的功能，与疾病发生发展相关。锌指蛋白家族的共性在于其保守的锌指结构域，能够介导蛋白与核酸的相互作用，广泛参与基因表达调控、细胞信号转导等过程。ZFX-AS1作为这一家族的相关基因，其功能研究仍在深入，可能为疾病诊断和治疗提供新的靶点。

OMIM entry for ZFX-AS1     Wikipedia entry for ZFX-AS1

Gene Sequence

Gene Sequence

Nucleotide sequence of ZFX-AS1:[NCBI]
Loading Gene Browser...

Gene Variants

Gene Variants

SNP variants of ZFX-AS1:           Showing partial SNPs
rs3761639       rs3761640       rs3838208       rs5990011       rs6526373       rs11795835       rs34848343       rs73474140       rs78155031       rs112380861       rs113207918       rs139447985       rs140372953       rs142707879       rs150537364       rs181789028       rs182414125      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AATGCGGAAGGGTAGACAG
60
GTCTTACATTTCACAGGCTCC
59
AATGCGGAAGGGTAGACAG
60
TCTTACATTTCACAGGCTCC
58
AATGCGGAAGGGTAGACAG
60
CTTACATTTCACAGGCTCCC
59

Related Publications

Related Publications

OVCH1 Antisense RNA 1 is differentially expressed between non-frail and frail old adults.
Abugessaisa I, Manabe RI, Kawashima T, Tagami M, Takahashi C, Okazaki Y, Bandinelli S, Kasukawa T, Ferrucci L Geroscience IF: 6.0 2024-00-00
ZFX-mediated upregulation of CEBPA-AS1 contributes to acute myeloid leukemia progression through miR-24-3p/CTBP2 axis.
Wang C, Song CM, Liu S, Chen LM, Xue SF, Huang SH, Lin H, Liu GH Cell Biol Toxicol IF: 5.7 2023-00-00
Construction and investigation of lncRNA-associated ceRNA regulatory network in papillary thyroid cancer.
Zhao Y, Wang H, Wu C, Yan M, Wu H, Wang J, Yang X, Shao Q Oncol Rep IF: 4.7 2018-03-00

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