ZFY (zinc finger protein Y-linked)

Gene Basic Information

Gene Basic Information

symbol:
ZFY
locus group:
protein-coding gene
location:
Yp11.2
gene_family:
Zinc fingers, C2H2-type
alias symbol:
ZNF911
alias name:
None
entrez id:
7544
ensembl gene id:
ENSG00000067646
ucsc gene id:
uc065cpg.1
refseq accession:
NM_003411
hgnc_id:
HGNC:12870
approved reserved:
1988-07-06

Chromosome Location

Chromosome Location

Yp11.2

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]

OMIM entry for ZFY     Wikipedia entry for ZFY

Gene Sequence

Gene Sequence

Nucleotide sequence of ZFY:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MDEDEFELQP QEPNSFFDGI GADATHMDGD QIVVEIQEAV
41FVSNIVDSDI TVHNFVPDDP DSVVIQDVVE DVVIEEDVQC
81 SDILEEADV SENVIIPEQV LDSDVTEEVS LPHCTVPDDV
121LASDITSTSM SMPEHVLTSE SMHVCDIGHV EHMVHDSVVE
161A EIITDPLT SDIVSEEVLV ADCAPEAVID ASGISVDQQD
201NDKASCEDYL MISLDDAGKI EHDGSTGVTI DAESEMDPCK
241VD STCPEVI KVYIFKADPG EDDLGGTVDI VESEPENDHG
281VELLDQNSSI RVPREKMVYM TVNDSQQEDE DLNVAEIADE
321VYM EVIVGE EDAAVAAAAA AVHEQQIDED EMKTFVPIAW
361AAAYGNNSDG IENRNGTASA LLHIDESAGL GRLAKQKPKK
401KRRP DSRQY QTAIIIGPDG HPLTVYPCMI CGKKFKSRGF
441LKRHMKNHPE HLAKKKYHCT DCDYTTNKKI SLHNHLESHK
481LTSKA EKAI ECDECGKHFS HAGALFTHKM VHKEKGANKM
521HKCKFCEYET AEQGLLNRHL LAVHSKNFPH ICVECGKGFR
561HPSELR KHM RIHTGEKPYQ CQYCEYRSAD SSNLKTHIKT
601KHSKEMPFKC DICLLTFSDT KEVQQHTLVH QESKTHQCLH
641CDHKSSN SS DLKRHVISVH TKDYPHKCEM CEKGFHRPSE
681LKKHVAVHKG KKMHQCRHCD FKIADPFVLS RHILSVHTKD
721LPFRCKRC R KGFRQQNELK KHMKTHSGRK VYQCEYCEYS
761TTDASGFKRH VISIHTKDYP HRCEYCKKGF RRPSEKNQHI
801MRHHKEVGL P
Structure predicted by AlphaFold DB(UniProt: P08048). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of ZFY:           Showing partial SNPs
rs781435110       rs781603575       rs781686736       rs781323393       rs781342980       rs781385769       rs781262843       rs780782580       rs780944575       rs781158102       rs780708462       rs780770704       rs780530885       rs780116674       rs780319162       rs780086135       rs779902727      

Gene Expression

Gene Expression

Tissue expression of ZFY:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GGAGAAGATGACTTAGGTGG
57
CTGATCAAGTAGTTCAACTCCA
58
GATTTCGTTGGATGATGCTG
58
AGGATCCATTTCTGATTCTGC
58
TGATGGAATAGTGGATGATGCT
60
TCCATTTCTGATTCTGCATCG
59
TGGAATAGGAGCTGATGCT
58
TGCACAGTTATGTCAGAATCC
59
GGAGAAGATGACTTAGGTGG
57
CTGATCAAGTAGTTCAACTCCA
58
GATTTCGTTGGATGATGCTG
58
AGGATCCATTTCTGATTCTGC
58
GATTTCGTTGGATGATGCTG
58
AGGATCCATTTCTGATTCTGC
58
ATAGATGAGTCTGCTGGCC
59
TCAGGGCCAATAATTATTGCTG
59
GATTTCGTTGGATGATGCTG
58
GGATCCATTTCTGATTCTGCA
59
ATGGAATAGGAGCTGATGCT
59
GCACAGTTATGTCAGAATCCA
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of ZFY (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for ZFY:

GO ID
Protein
Source DB
GO:0000977
P08048 (UniProtKB)
IBA
GO:0003700
P08048 (UniProtKB)
IBA
GO:0005634
P08048 (UniProtKB)
IEA
GO:0006351
P08048 (UniProtKB)
IEA
GO:0006355
P08048 (UniProtKB)
IBA
GO:0007275
P08048 (UniProtKB)
IBA
GO:0046872
P08048 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating ZFY:     

Gene Interactions

Gene Interactions

String
BioGrid
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Turner Syndrome 0.000814326 3 0 BeFree
Penile hypospadias 0.000271442 1 0 BeFree
Swyer Syndrome 0.000271442 1 0 BeFree
Hypospadias 0.000271442 1 0 BeFree
Adenocarcinoma of prostate 0.000271442 1 0 BeFree
Complete trisomy 18 syndrome 0.000271442 1 0 BeFree
Gonadal Dysgenesis 0.000271442 1 0 BeFree
Down Syndrome 0.000271442 1 0 BeFree
Gonadal Dysgenesis, 46,XY 0.000271442 1 0 BeFree
Gonadal Dysgenesis, Mixed 0.000271442 1 0 BeFree

Related Publications

Related Publications

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Pauciullo A, Nicodemo D, Letaief N, Černohorská H, Kubičková S, Vozdová M, Parma P, Iannuzzi L, Cosenza G Genes (Basel) IF: 3.600 2026-08-13
The Y Chromosome is a Reliable Marker for Deep-Time Phylogenetic Inference.
Alexander EP, Foley NM, Murphy WJ Syst Biol IF: 6.2 2026-07-22
Species delimitation based on phylogenetic analyses of males: A case study revealing the complex evolutionary history of giraffes.
Hassanin A, Jullemier E, Chardonnet B, Robinson TJ Mol Phylogenet Evol IF: 4.0 2026-05-00
Paramesonephric (Müllerian) tumor in a rabbit initially misidentified as male: clinical, histologic, and molecular findings.
Maeda K, Kusumoto K, Takanosu M, Kagawa Y, Kawasaki N, Kakizaki T, Iwai S, Okano S J Vet Diagn Invest IF: 1.4 2026-04-27
Tightening the Sphincter on Faecal Sample Anonymity: The Case of the Weddell Seal (Leptonychotes weddellii).
van den Hoff J, Fanson KV, Polanowski A, Wotherspoon S Zoo Biol IF: 1.5 2026-06-06
Large-scale transcriptomic analyses reveal downstream target genes of ZFY1 and ZFY2 transcription factors in male germ cells.
Holmlund H, Coulée M, Yamauchi Y, Yarbabaeva B, Tekayev M, Garcia IR, Feudjio OU, de la Iglesia A, Larcombe L, Ellis PJI, Cocquet J, Ward MA Cell Death Differ IF: 13.6 2026-02-00

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