ADK (adenosine kinase)

Gene Basic Information

Gene Basic Information

symbol
ADK
locus group
protein-coding gene
location
10q22.2
gene_family
-
alias symbol
AK
alias name
adenosine 5'-phosphotransferase
entrez id
132
ensembl gene id
ENSG00000156110
ucsc gene id
uc001jwi.4
refseq accession
NM_006721
hgnc_id
HGNC:257
approved reserved
1986-01-01

Chromosome Location

Chromosome Location

10q22.2

Gene Summary

Gene Summary

ChineseEnglish

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

OMIM entry for ADK     Wikipedia entry for ADK

Gene Sequence

Gene Sequence

Nucleotide sequence of ADK:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAAAEEEPKP KKLKVEAPQA LRENILFGMG NPLLDISAVV
41DKDFLDKYSL KPNDQILAED KHKELFDELV KKFKVEYHAG
81 GSTQNSIKV AQWMIQQPHK AATFFGCIGI DKFGEILKRK
121AAEAHVDAHY YEQNEQPTGT CAACITGDNR SLIANLAAAN
161C YKKEKHLD LEKNWMLVEK ARVCYIAGFF LTVSPESVLK
201VAHHASENNR IFTLNLSAPF ISQFYKESLM KVMPYVDILF
241GN ETEAATF AREQGFETKD IKEIAKKTQA LPKMNSKRQR
281IVIFTQGRDD TIMATESEVT AFAVLDQDQK EIIDTNGAGD
321AFV GGFLSQ LVSDKPLTEC IRAGHYAASI IIRRTGCTFP
361EKPDFH
Structure predicted by AlphaFold DB(UniProt: P55263). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of ADK:           Showing partial SNPs
rs1529       rs1531       rs714446       rs719624       rs719944       rs726120       rs730660       rs768959       rs871267       rs946184       rs946185       rs946186       rs949720       rs956118       rs958620       rs961321       rs1051938      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AATGAGACAGAAGCTGCCA
59
GAGTTCATCTTTGGCAGGG
59
GCTGTAGTGGACAAAGATTTCC
60
GCCAAGATTTGGTCATTTGGT
60
AATGAGACAGAAGCTGCCA
59
GAGTTCATCTTTGGCAGGG
59
AAATGAGACAGAAGCTGCC
58
TGAGTTCATCTTTGGCAGG
58
ATATAGCAGAAGCTGCCAC
57
CTCTTTGAGTTCATCTTTGGC
58
ATGAGACAACTTACCACATCTG
58
GACACTTGGAAGCAAGAGG
59
TACTACGAGCAGAATGAGCAG
60
AAGATTAGCTATGAGGGACCTG
59
AAATGAGACAGAAGCTGCC
58
GAGTTCATCTTTGGCAGGG
59
TGGAAATGAGACAACTTACCAC
59
AAGAGGGCCACTCTATTAAGG
59
CTGTAGTGGACAAAGATTTCCT
58
CACAAGTTCATCAAACAGTTCC
59

Gene Ontology

Subcellular localization of ADK (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for ADK:

GO ID
Protein
Source DB
GO:0004001
P55263 (UniProtKB)
EXP
GO:0004001
P55263 (UniProtKB)
EXP
GO:0005524
P55263 (UniProtKB)
IEA
GO:0005654
P55263 (UniProtKB)
IDA
GO:0005737
P55263 (UniProtKB)
IDA
GO:0005829
P55263 (UniProtKB)
TAS
GO:0006175
P55263 (UniProtKB)
IEA
GO:0009156
P55263 (UniProtKB)
TAS
GO:0010613
P55263 (UniProtKB)
IEA
GO:0016310
P55263 (UniProtKB)
IEA
GO:0032922
P55263 (UniProtKB)
IEA
GO:0042102
P55263 (UniProtKB)
IEA
GO:0043101
P55263 (UniProtKB)
TAS
GO:0044209
P55263 (UniProtKB)
IEA
GO:0044342
P55263 (UniProtKB)
IEA
GO:0044822
P55263 (UniProtKB)
IDA
GO:0046085
P55263 (UniProtKB)
IEA
GO:0046872
P55263 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating ADK:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
HYPERMETHIONINEMIA DUE TO ADENOSINE KINASE DEFICIENCY 0.36 1 2 CLINVAR_ORPHANET_UNIPROT
Anoxia 0.12272435 2 0 CTD_human_LHGDN
Hypospadias 0.12 1 1 GWASCAT
Intellectual Disability 0.12 1 0 CTD_human
Epilepsy, Temporal Lobe 0.080271442 2 0 BeFree_RGD
Diabetes Mellitus, Experimental 0.08 1 0 RGD
Hypotension 0.08 1 0 RGD
Arthritis, Experimental 0.08 1 0 RGD
Fatty metamorphosis of viscera 0.08 0 0 MGD
Brain Infarction 0.08 1 0 RGD

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