CAT (catalase)

Gene Basic Information

Gene Basic Information

symbol
CAT
locus group
protein-coding gene
location
11p13
gene_family
-
alias symbol
-
alias name
None
entrez id
847
ensembl gene id
ENSG00000121691
ucsc gene id
uc001mvm.4
refseq accession
NM_001752
hgnc_id
HGNC:1516
approved reserved
2001-06-22

Chromosome Location

Chromosome Location

11p13

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

OMIM entry for CAT     Wikipedia entry for CAT

Gene Sequence

Gene Sequence

Nucleotide sequence of CAT:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MADSRDPASD QMQHWKEQRA AQKADVLTTG AGNPVGDKLN
41VITVGPRGPL LVQDVVFTDE MAHFDRERIP ERVVHAKGAG
81 AFGYFEVTH DITKYSKAKV FEHIGKKTPI AVRFSTVAGE
121SGSADTVRDP RGFAVKFYTE DGNWDLVGNN TPIFFIRDPI
161L FPSFIHSQ KRNPQTHLKD PDMVWDFWSL RPESLHQVSF
201LFSDRGIPDG HRHMNGYGSH TFKLVNANGE AVYCKFHYKT
241DQ GIKNLSV EDAARLSQED PDYGIRDLFN AIATGKYPSW
281TFYIQVMTFN QAETFPFNPF DLTKVWPHKD YPLIPVGKLV
321LNR NPVNYF AEVEQIAFDP SNMPPGIEAS PDKMLQGRLF
361AYPDTHRHRL GPNYLHIPVN CPYRARVANY QRDGPMCMQD
401NQGG APNYY PNSFGAPEQQ PSALEHSIQY SGEVRRFNTA
441NDDNVTQVRA FYVNVLNEEQ RKRLCENIAG HLKDAQIFIQ
481KKAVK NFTE VHPDYGSHIQ ALLDKYNAEK PKNAIHTFVQ
521SGSHLAAREK ANL
Structure predicted by AlphaFold DB(UniProt: P04040). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of CAT:           Showing partial SNPs
rs14527       rs475043       rs480496       rs480575       rs482322       rs484214       rs486256       rs494024       rs499406       rs508370       rs511895       rs515130       rs524154       rs524167       rs525938       rs533425       rs543701      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ATATACCTGTGAACTGTCCCT
58
TAATTTGGAGCACCACCCT
59
TAACGTTACTCAGGTGCGG
60
AATTTGTGCATCCTTCAGGTG
60
ATATACCTGTGAACTGTCCCT
58
TAATTTGGAGCACCACCCT
59
CGATCTCACCAAGGTTTGG
59
GCTATCTGTTCAACCTCAGC
59
CTGAGAAGCCTAAGAATGCG
59
CCTCACAGATTTGCCTTCTC
59
TCCATTATAAGACTGACCAGGG
59
CATAGTCAGGATCTTCCTGGG
60
CCTGTGAACTGTCCCTACC
59
TAATTTGGAGCACCACCCT
59
TTCCATTATAAGACTGACCAGG
57
ATAGTCAGGATCTTCCTGGG
58
CCTGTGAACTGTCCCTACC
59
TAATTTGGAGCACCACCCT
59
ATAACGTTACTCAGGTGCG
58
TTTGTGCATCCTTCAGGTG
58

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
EGR3
CAT
Activation
1906159
ETV1
CAT
Unknown
19763505
NFE2L2
CAT
Activation
22493435
PPARD
CAT
Activation
18048767
PPARG
CAT
Unknown
20075562
SP1
CAT
Unknown
11479230

Gene Ontology

Subcellular localization of CAT (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for CAT:

GO ID
Protein
Source DB
GO:0000302
P04040 (UniProtKB)
IMP
GO:0000302
P04040 (UniProtKB)
TAS
GO:0001649
P04040 (UniProtKB)
IDA
GO:0001657
P04040 (UniProtKB)
IEA
GO:0001666
P04040 (UniProtKB)
IEA
GO:0004046
P04040 (UniProtKB)
IEA
GO:0004096
P04040 (UniProtKB)
IDA
GO:0004096
P04040 (UniProtKB)
IDA
GO:0004096
P04040 (UniProtKB)
IDA
GO:0004096
P04040 (UniProtKB)
TAS
GO:0005102
P04040 (UniProtKB)
IPI
GO:0005102
P04040 (UniProtKB)
IPI
GO:0005615
P04040 (UniProtKB)
IEA
GO:0005739
P04040 (UniProtKB)
IBA
GO:0005758
P04040 (UniProtKB)
IEA
GO:0005764
P04040 (UniProtKB)
IEA
GO:0005777
P04040 (UniProtKB)
IDA
GO:0005777
P04040 (UniProtKB)
IDA
GO:0005777
P04040 (UniProtKB)
IDA
GO:0005777
P04040 (UniProtKB)
IDA
GO:0005778
P04040 (UniProtKB)
ISS
GO:0005782
P04040 (UniProtKB)
TAS
GO:0005783
P04040 (UniProtKB)
IEA
GO:0005794
P04040 (UniProtKB)
IEA
GO:0005829
P04040 (UniProtKB)
IEA
GO:0005886
P04040 (UniProtKB)
IEA
GO:0005925
P04040 (UniProtKB)
IDA
GO:0006195
P04040 (UniProtKB)
TAS
GO:0006641
P04040 (UniProtKB)
IEA
GO:0007568
P04040 (UniProtKB)
IEA
GO:0008203
P04040 (UniProtKB)
IEA
GO:0009060
P04040 (UniProtKB)
IEA
GO:0009642
P04040 (UniProtKB)
IEA
GO:0009650
P04040 (UniProtKB)
IMP
GO:0009650
P04040 (UniProtKB)
IMP
GO:0010193
P04040 (UniProtKB)
IEA
GO:0010288
P04040 (UniProtKB)
IEA
GO:0014068
P04040 (UniProtKB)
IEA
GO:0014823
P04040 (UniProtKB)
IEA
GO:0014854
P04040 (UniProtKB)
IEA
GO:0016020
P04040 (UniProtKB)
IDA
GO:0016020
P04040 (UniProtKB)
IDA
GO:0016209
P04040 (UniProtKB)
IDA
GO:0016684
P04040 (UniProtKB)
ISS
GO:0019899
P04040 (UniProtKB)
IPI
GO:0020027
P04040 (UniProtKB)
IEA
GO:0020037
P04040 (UniProtKB)
IDA
GO:0020037
P04040 (UniProtKB)
IDA
GO:0032088
P04040 (UniProtKB)
IEA
GO:0032355
P04040 (UniProtKB)
IEA
GO:0032868
P04040 (UniProtKB)
IEA
GO:0033189
P04040 (UniProtKB)
IEA
GO:0033197
P04040 (UniProtKB)
IEA
GO:0033591
P04040 (UniProtKB)
IEA
GO:0042493
P04040 (UniProtKB)
IEA
GO:0042542
P04040 (UniProtKB)
IBA
GO:0042744
P04040 (UniProtKB)
IDA
GO:0042803
P04040 (UniProtKB)
IDA
GO:0043066
P04040 (UniProtKB)
IMP
GO:0043231
P04040 (UniProtKB)
IDA
GO:0045471
P04040 (UniProtKB)
IEA
GO:0046686
P04040 (UniProtKB)
IEA
GO:0046872
P04040 (UniProtKB)
IEA
GO:0050661
P04040 (UniProtKB)
IDA
GO:0051092
P04040 (UniProtKB)
IEA
GO:0051262
P04040 (UniProtKB)
IDA
GO:0051262
P04040 (UniProtKB)
IDA
GO:0051289
P04040 (UniProtKB)
IDA
GO:0051781
P04040 (UniProtKB)
IEA
GO:0055093
P04040 (UniProtKB)
IEA
GO:0070062
P04040 (UniProtKB)
IDA
GO:0070062
P04040 (UniProtKB)
IDA
GO:0070542
P04040 (UniProtKB)
IEA
GO:0071363
P04040 (UniProtKB)
IEA
GO:0080184
P04040 (UniProtKB)
IEA
GO:0098869
P04040 (UniProtKB)
IEA
GO:0098869
P04040 (UniProtKB)
IEA
GO:0098869
P04040 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating CAT:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Acatalasia 0.362442977 12 0 BeFree_CLINVAR_CTD_human_ORPHANET
Hypertensive disease 0.219369519 18 0 BeFree_CTD_human_GAD_LHGDN_RGD
Kidney Failure, Chronic 0.202638474 5 0 BeFree_CTD_human_GAD_RGD
Fatty Liver 0.200271442 3 0 BeFree_CTD_human_RGD
Hyperthyroidism 0.2 2 0 CTD_human_RGD
Reperfusion Injury 0.2 6 0 CTD_human_RGD
Myocardial Infarction 0.2 2 0 CTD_human_RGD
Brain Ischemia 0.2 2 0 CTD_human_RGD
Diabetes Mellitus, Experimental 0.2 4 0 CTD_human_RGD
Myocardial Reperfusion Injury 0.2 2 0 CTD_human_RGD

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