FYN (FYN proto-oncogene, Src family tyrosine kinase)

基因基本信息

基因基本信息

symbol:
FYN
locus group:
protein-coding gene
location:
6q21
gene_family:
SH2 domain containing
alias symbol:
SYN|SLK|MGC45350
alias name:
None
entrez id:
2534
ensembl gene id:
ENSG00000010810
ucsc gene id:
uc003pvk.3
refseq accession:
NM_001370529
hgnc_id:
HGNC:4037
approved reserved:
1988-08-19

基因染色体位置

基因染色体位置

6q21

基因简述

基因简述

FYN是一种属于SRC家族的非受体型酪氨酸激酶基因，在细胞信号传导中发挥重要作用。该基因编码的Fyn蛋白广泛分布于多种组织中，尤其在神经系统和免疫系统中表达丰富。Fyn蛋白通过其SH2和SH3结构域与其他蛋白质相互作用，参与调控T细胞受体信号通路、神经元发育、突触可塑性以及细胞黏附等关键生物学过程。在免疫系统中，Fyn与Lck协同作用，参与T细胞激活的早期信号事件。在神经系统中，Fyn通过调节NMDA受体和髓鞘形成影响学习记忆功能。FYN基因突变可能导致多种疾病，包括神经系统疾病如阿尔茨海默病（通过影响tau蛋白磷酸化）和免疫系统异常。FYN过表达与某些癌症如乳腺癌和前列腺癌的进展相关，可能促进肿瘤细胞迁移和侵袭；而表达降低则可能损害T细胞功能导致免疫缺陷。FYN属于SRC基因家族，该家族成员均含有SH2、SH3结构域和激酶结构域，通过酪氨酸磷酸化参与细胞信号转导，在细胞生长、分化、存活和运动等过程中起调控作用。SRC家族激酶通常通过与细胞膜受体结合而被激活，其活性异常与多种癌症发生密切相关。

中文English

该基??因是蛋白质 - 酪氨酸激酶致癌基因家族的一个成员。它编码已在细胞生长的控制被牵连的膜相关的酪氨酸激酶。与磷脂酰肌醇3激酶的P85亚基蛋白联营公司及与菲英岛结合蛋白相互作用。存在选择性剪接转录变异体的编码不同的亚型。 [由RefSeq的，2008年7月提供]

OMIM数据库中对FYN基因的介绍     Wikipedia数据库中对FYN基因的介绍

基因序列

基因序列

FYN基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP
41SFGVTSIPNY NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG
81 GTGVTLFVA LYDYEARTED DLSFHKGEKF QILNSSEGDW
121WEARSLTTGE TGYIPSNYVA PVDSIQAEEW YFGKLGRKDA
161E RQLLSFGN PRGTFLIRES ETTKGAYSLS IRDWDDMKGD
201HVKHYKIRKL DNGGYYITTR AQFETLQQLV QHYSERAAGL
241CC RLVVPCH KGMPRLTDLS VKTKDVWEIP RESLQLIKRL
281GNGQFGEVWM GTWNGNTKVA IKTLKPGTMS PESFLEEAQI
321MKK LKHDKL VQLYAVVSEE PIYIVTEYMN KGSLLDFLKD
361GEGRALKLPN LVDMAAQVAA GMAYIERMNY IHRDLRSANI
401LVGN GLICK IADFGLARLI EDNEYTARQG AKFPIKWTAP
441EAALYGRFTI KSDVWSFGIL LTELVTKGRV PYPGMNNREV
481LEQVE RGYR MPCPQDCPIS LHELMIHCWK KDPEERPTFE
521YLQSFLEDYF TATEPQYQPG ENL
结构预测来自 AlphaFold DB（UniProt: P06241），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

FYN基因的碱基突变：           仅显示部分snp
rs12910       rs697640       rs697641       rs697642       rs706861       rs706862       rs706863       rs706864       rs706865       rs706866       rs706867       rs706868       rs706869       rs706870       rs706871       rs706872       rs706873      

基因表达

基因表达

FYN基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTCTTCATCACAGGGAAGGA
59
AGCCACATAATTGCTGGGA
59
AAGGACTCACCGTCTTTGG
60
AAGAGTGTCACTCCTGTTCC
59
TGGATACTACATTACCACCCG
59
AAACCATCAGCTTTCTCTGAG
58
TATTGAACAGCTCGGAAGG
57
CATAATTGCTGGGAATGTAACC
57
TGGATACTACATTACCACCCG
59
AAACCATCAGCTTTCTCTGAG
58
AAGGACTCACCGTCTTTGG
60
AAGAGTGTCACTCCTGTTCC
59
TATTGAACAGCTCGGAAGG
57
CATAATTGCTGGGAATGTAACC
58
CGACAGCTATTGTCCTTTGG
59
AAAGTGAATAGGCACCTTTGG
59
TATCCAGGCAGAAGAGTGG
59
TCTTGGGTTTCCAAAGGAC
58
AAGGACTCACCGTCTTTGG
59
AAGAGTGTCACTCCTGTTCC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

FYN基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

FYN基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000165
P06241 (UniProtKB)
TAS
GO:0001664
P06241 (UniProtKB)
IEA
GO:0001764
P06241 (UniProtKB)
IEA
GO:0001948
P06241 (UniProtKB)
IPI
GO:0002223
P06241 (UniProtKB)
TAS
GO:0002250
P06241 (UniProtKB)
IEA
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
IMP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004715
P06241 (UniProtKB)
IBA
GO:0004715
P06241 (UniProtKB)
NAS
GO:0005088
P06241 (UniProtKB)
TAS
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005524
P06241 (UniProtKB)
IEA
GO:0005634
P06241 (UniProtKB)
IEA
GO:0005739
P06241 (UniProtKB)
IEA
GO:0005768
P06241 (UniProtKB)
IDA
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005884
P06241 (UniProtKB)
IEA
GO:0005886
P06241 (UniProtKB)
IDA
GO:0005886
P06241 (UniProtKB)
IDA
GO:0006468
P06241 (UniProtKB)
NAS
GO:0006816
P06241 (UniProtKB)
NAS
GO:0007169
P06241 (UniProtKB)
IBA
GO:0007411
P06241 (UniProtKB)
TAS
GO:0007417
P06241 (UniProtKB)
IBA
GO:0007596
P06241 (UniProtKB)
TAS
GO:0007612
P06241 (UniProtKB)
TAS
GO:0007631
P06241 (UniProtKB)
TAS
GO:0008360
P06241 (UniProtKB)
IEA
GO:0010629
P06241 (UniProtKB)
IEA
GO:0010976
P06241 (UniProtKB)
IEA
GO:0014066
P06241 (UniProtKB)
TAS
GO:0014068
P06241 (UniProtKB)
IEA
GO:0014069
P06241 (UniProtKB)
IEA
GO:0015631
P06241 (UniProtKB)
IEA
GO:0016032
P06241 (UniProtKB)
IEA
GO:0016477
P06241 (UniProtKB)
IBA
GO:0018108
P06241 (UniProtKB)
IMP
GO:0030154
P06241 (UniProtKB)
IBA
GO:0030168
P06241 (UniProtKB)
TAS
GO:0030900
P06241 (UniProtKB)
IEA
GO:0031234
P06241 (UniProtKB)
IBA
GO:0031295
P06241 (UniProtKB)
TAS
GO:0031295
P06241 (UniProtKB)
TAS
GO:0031397
P06241 (UniProtKB)
IEA
GO:0035556
P06241 (UniProtKB)
TAS
GO:0036120
P06241 (UniProtKB)
IEA
GO:0038083
P06241 (UniProtKB)
IBA
GO:0038096
P06241 (UniProtKB)
TAS
GO:0042110
P06241 (UniProtKB)
IBA
GO:0042127
P06241 (UniProtKB)
IBA
GO:0042177
P06241 (UniProtKB)
IEA
GO:0042493
P06241 (UniProtKB)
IEA
GO:0042523
P06241 (UniProtKB)
IEA
GO:0042608
P06241 (UniProtKB)
IEA
GO:0042609
P06241 (UniProtKB)
IEA
GO:0042610
P06241 (UniProtKB)
IEA
GO:0042981
P06241 (UniProtKB)
IBA
GO:0043123
P06241 (UniProtKB)
IEA
GO:0043524
P06241 (UniProtKB)
IEA
GO:0043547
P06241 (UniProtKB)
IEA
GO:0043548
P06241 (UniProtKB)
IEA
GO:0044325
P06241 (UniProtKB)
IEA
GO:0045087
P06241 (UniProtKB)
IBA
GO:0045471
P06241 (UniProtKB)
IEA
GO:0046854
P06241 (UniProtKB)
IEA
GO:0046872
P06241 (UniProtKB)
IEA
GO:0046875
P06241 (UniProtKB)
IPI
GO:0046934
P06241 (UniProtKB)
TAS
GO:0048010
P06241 (UniProtKB)
TAS
GO:0048013
P06241 (UniProtKB)
TAS
GO:0048015
P06241 (UniProtKB)
TAS
GO:0048813
P06241 (UniProtKB)
IEA
GO:0050690
P06241 (UniProtKB)
TAS
GO:0050798
P06241 (UniProtKB)
IEA
GO:0050852
P06241 (UniProtKB)
IDA
GO:0050900
P06241 (UniProtKB)
TAS
GO:0050966
P06241 (UniProtKB)
IEA
GO:0051428
P06241 (UniProtKB)
IEA
GO:0070851
P06241 (UniProtKB)
IPI
GO:0071375
P06241 (UniProtKB)
IEA
GO:0071560
P06241 (UniProtKB)
IEA
GO:1900182
P06241 (UniProtKB)
IEA
GO:2001240
P06241 (UniProtKB)
IEA
GO:0045121
P06241 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 FYN基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Peripheral T-Cell Lymphoma 0.120271442 1 0 BeFree_CTD_human
Stomach Neoplasms 0.12 1 0 CTD_human
Catalepsy 0.12 1 0 CTD_human
Adult T-Cell Lymphoma/Leukemia 0.12 1 0 CTD_human
Sepsis 0.08 1 0 RGD
Epilepsy, Temporal Lobe 0.08 1 0 RGD
Alzheimer's Disease 0.010454206 5 0 BeFree_GAD_LHGDN
Asthma 0.005634266 2 5 BeFree_GAD_LHGDN
Schizophrenia 0.00554839 5 0 BeFree_GAD
Bipolar Disorder 0.005276948 2 0 BeFree_GAD

基因相关文献

基因相关文献

Role of Src family kinases Fyn and Lyn in arenavirus infection.
Mao W, Zhou M, Peng C, Wan Y, Li L, Hu J, Liu Y, Peng Y, Shan C, Deng F, Yuan Z, Wang W J Virol IF: 4.1 2026-04-21
Multi-tissue multi-omics integration reveals tissue-specific pathways, gene networks and drug candidates for type 1 diabetes.
Blencowe M, Saleem Z, Liu R, Wang M, Tseng IH, Wier J, Mutter S, Vaida F, Guo Y, Sandholm N, Ackeifi C, Kaufman DL, Yang X Diabetologia IF: 10.4 2026-07-00
Integrated bioinformatics analysis of molecular signatures and therapeutic targets in early sepsis.
Gai X, Li Y, Wang Y, Gao D, Wu S, Geng Y, Zhang J, Yao M, Yao G, Wang Q Front Cell Infect Microbiol IF: 5.5 None
Selective disruption of tau-SH3 interactions rescues seizure and sleep phenotypes.
Shandilya MCV, Koutures A, Addo-Osafo K, Hwang K, Vicente M, Ewens AN, Katz BM, Peters ST, Choquette JM, Vaknalli RN, Venkateswaran N, Onanyan N, Narasani A, Ravishankar S, Stepter J, Western A, Benneyworth MA, Cohn W, John V, Whitelegge JP, Vossel K Brain IF: 12.6 2026-03-09
FYN/LCK kinase balance as a metabolic switch orchestrates progenitor-exhausted T-cell differentiation in hepatocellular carcinoma.
Wu J, Jiang Z, Li Q, Cheng CS, Chan YT, Yeerken R, Chen J, Lu P, Feng Z, Yuan H, Xu L, Meng Z, Feng Y, Tan HY, Wang N Hepatology IF: 18.0 2026-03-11
KR-62980, a novel PPARγ agonist, inhibits collagen-induced platelet activation and thrombus formation by regulating the GPVI signaling pathway.
Wang SB, Park JW, Kim P, Oh EB, Kim S, Sohn J, Kim T, Ahn JH, Chang TS Biochem Pharmacol IF: 6.5 2026-07-00

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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