GSC (goosecoid homeobox)

Gene Basic Information

Gene Basic Information

symbol
GSC
locus group
protein-coding gene
location
14q32.13
gene_family
PRD class homeoboxes and pseudogenes
alias symbol
-
alias name
None
entrez id
145258
ensembl gene id
ENSG00000133937
ucsc gene id
uc001ydu.4
refseq accession
NM_173849
hgnc_id
HGNC:4612
approved reserved
1993-12-13

Chromosome Location

Chromosome Location

14q32.13

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]

OMIM entry for GSC     Wikipedia entry for GSC

Gene Sequence

Gene Sequence

Nucleotide sequence of GSC:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MPASMFSIDN ILAARPRCKD SVLPVAHSAA APVVFPALHG
41DSLYGASGGA SSDYGAFYPR PVAPGGAGLP AAVSGSRLGY
81 NNYFYGQLH VQAAPVGPAC CGAVPPLGAQ QCSCVPTPPG
121YEGPGSVLVS PVPHQMLPYM NVGTLSRTEL QLLNQLHCRR
161K RRHRTIFT DEQLEALENL FQETKYPDVG TREQLARKVH
201LREEKVEVWF KNRRAKWRRQ KRSSSEESEN AEKWNKTSSS
241KA SPEKREE EGKSDLDSDS
Structure predicted by AlphaFold DB(UniProt: P56915). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of GSC:           Showing partial SNPs
rs1243531       rs3850401       rs3850402       rs3905049       rs4511463       rs4900248       rs7161266       rs60702541       rs61977111       rs72698873       rs112647490       rs114851113       rs115447257       rs116232022       rs116631475       rs117555620       rs137930313      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TTCCAGGAGACCAAGTACC
58
GTTCTTAAACCAGACCTCCAC
59
CTTCCAGGAGACCAAGTACC
60
TAAACCAGACCTCCACTTTCTC
60
GAGGAGAAAGTGGAGGTCTG
60
CTCCGACTCCTCTGATGAG
59

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
EVX1
GSC
Repression
22178155
GSC
GSC2
Unknown
9441739

Gene Ontology

Subcellular localization of GSC (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for GSC:

GO ID
Protein
Source DB
GO:0000122
P56915 (UniProtKB)
IEA
GO:0001085
P56915 (UniProtKB)
ISS
GO:0001103
P56915 (UniProtKB)
ISS
GO:0005634
P56915 (UniProtKB)
IEA
GO:0005667
P56915 (UniProtKB)
IEA
GO:0007369
P56915 (UniProtKB)
NAS
GO:0014036
P56915 (UniProtKB)
IMP
GO:0021904
P56915 (UniProtKB)
IEA
GO:0023019
P56915 (UniProtKB)
IEA
GO:0030178
P56915 (UniProtKB)
IEA
GO:0030900
P56915 (UniProtKB)
IEA
GO:0042474
P56915 (UniProtKB)
ISS
GO:0043565
P56915 (UniProtKB)
IEA
GO:0048644
P56915 (UniProtKB)
IEA
GO:0048704
P56915 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating GSC:     

Gene Interactions

Gene Interactions

String
BioGrid
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
SHORT STATURE, AUDITORY CANAL ATRESIA, MANDIBULAR HYPOPLASIA, SKELETAL ABNORMALITIES 0.240542884 2 3 BeFree_CLINVAR_ORPHANET
Craniofacial Abnormalities 0.12 1 0 CTD_human
Glioma 0.003528744 13 0 BeFree
Congenital Abnormality 0.002909916 3 0 BeFree_GAD
Glioblastoma 0.002442977 9 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.002367032 1 0 GAD
Glioblastoma Multiforme 0.000542884 2 0 BeFree
Neoplasms, Intracranial 0.000542884 2 0 BeFree
Cornelia De Lange Syndrome 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree

Related Publications

Related Publications

Understanding Glioblastoma Dynamics Using 3D Organoids and Engineered Extracellular Matrix.
McManis A, Jimenez CA, Shirolkar A, Raza Ur Rehman S, Mallick S, Murphy M, Gaharwar AK, Singh I Adv Sci (Weinh) IF: 9.034 2026-04-00
SCD1 and SCD5 modulate PARP-dependent DNA repair via fatty acid desaturation in glioblastoma.
Mnatsakanyan H, Sammarco A, Hewett A, Awwad R, Roumieh E, Pechdimaljian C, Cakici C, Spangler CM, Azar Y, Pradhan R, Su B, Williams KJ, Bensinger SJ, Badr CE Cell Rep IF: 6.9 2026-04-13
Non-cell-autonomous regulation of testicular stem cell niche homeostasis by the 20S proteasome core particle through cell adhesion and cyclin proteins.
Li J, Wang C, Qian W, He L, Huang Q, Zhao J, Cao Z, Huang Y, Wang Y, Wang X, Du Y, Li X, Zhu G, Li Y, Yu J, Tan X, Li Z Open Biol IF: 3.481 2026-04-15
Signal triangulation coordinates cell fate decisions in the developing jaw.
Paulissen E, Junaid M, Brugger L, Chen HJ, Crump JG bioRxiv 2026-04-08
Dual suppression of stemness and redox adaptation in glioblastoma through filaggrin upregulation by an abiraterone-based HDAC inhibitor.
Tran HY, Sharma R, Lin HY, Yeh TY, Shen CJ, Hsu TI, Liou JP J Biomed Sci IF: 14.5 2026-04-06

Related Services

Related Services

Comments

Comments

Loading comments...

Log in to post comments Log In Sign Up

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2