LCK (LCK proto-oncogene, Src family tyrosine kinase)

Gene Basic Information

Gene Basic Information

symbol:
LCK
locus group:
protein-coding gene
location:
1p35.2
gene_family:
SH2 domain containing
alias symbol:
None
alias name:
None
entrez id:
3932
ensembl gene id:
ENSG00000182866
ucsc gene id:
uc001bux.3
refseq accession:
NM_005356
hgnc_id:
HGNC:6524
approved reserved:
1986-01-01

Chromosome Location

Chromosome Location

1p35.2

Gene Summary

Gene Summary

ChineseEnglish

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]

OMIM entry for LCK     Wikipedia entry for LCK

Gene Sequence

Gene Sequence

Nucleotide sequence of LCK:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN
41GSEVRDPLVT YEGSNPPASP LQDNLVIALH SYEPSHDGDL
81 GFEKGEQLR ILEQSGEWWK AQSLTTGQEG FIPFNFVAKA
121NSLEPEPWFF KNLSRKDAER QLLAPGNTHG SFLIRESEST
161A GSFSLSVR DFDQNQGEVV KHYKIRNLDN GGFYISPRIT
201FPGLHELVRH YTNASDGLCT RLSRPCQTQK PQKPWWEDEW
241EV PRETLKL VERLGAGQFG EVWMGYYNGH TKVAVKSLKQ
281GSMSPDAFLA EANLMKQLQH QRLVRLYAVV TQEPIYIITE
321YME NGSLVD FLKTPSGIKL TINKLLDMAA QIAEGMAFIE
361ERNYIHRDLR AANILVSDTL SCKIADFGLA RLIEDNEYTA
401REGA KFPIK WTAPEAINYG TFTIKSDVWS FGILLTEIVT
441HGRIPYPGMT NPEVIQNLER GYRMVRPDNC PEELYQLMRL
481CWKER PEDR PTFDYLRSVL EDFFTATEGQ YQPQP
Structure predicted by AlphaFold DB(UniProt: P06239). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of LCK:           Showing partial SNPs
rs138714968       rs187168048       rs531467555       rs640492       rs670025       rs690375       rs695161       rs1004420       rs1042519       rs1042546       rs1079720       rs1126767       rs1801124       rs2077077       rs2086257       rs3935269       rs6425795      

Gene Expression

Gene Expression

Tissue expression of LCK:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CATCCGAAATGGCTCTGAG
58
ATAACCAGGTTGTCTTGCAG
58
GATCTGGGCTTTGAGAAGG
58
GTTCTTGAAGAACCAGGGT
57
AACGGTGGCTTCTACATCTC
60
CCCGTTGTAGTACCTGGTG
60
ACGGTGGCTTCTACATCTC
59
CCCATCTGAAGCATTGGTG
59
AACGGTGGCTTCTACATCTC
60
CCCGTTGTAGTACCTGGTG
60
GATCTGGGCTTTGAGAAGG
57
GTTCTTGAAGAACCAGGGT
57
TGAATACATGGAGAATGGGAG
57
TCCAGGAGTTTGTTGATGG
57
CTGAATACATGGAGAATGACAC
57
ATCCACTAGACTCCCTGTG
58
TGAATACATGGAGAATGGGAG
57
TCCAGGAGTTTGTTGATGG
57
CATCCGAAATGGCTCTGAG
58
ATAACCAGGTTGTCTTGCAG
58

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
ETS1
LCK
Activation
7970721
ETS2
LCK
Activation
7970721
MYB
LCK
Activation
7970721

Gene Ontology

Subcellular localization of LCK (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for LCK:

GO ID
Protein
Source DB
GO:0004715
E9PJ92 (UniProtKB)
IEA
GO:0005524
E9PJ92 (UniProtKB)
IEA
GO:0018108
E9PJ92 (UniProtKB)
IEA
GO:0018108
E9PJ92 (UniProtKB)
IEA
GO:0000242
P06239 (UniProtKB)
ISS
GO:0000242
P06239 (UniProtKB)
IDA
GO:0001772
P06239 (UniProtKB)
IDA
GO:0001948
P06239 (UniProtKB)
IPI
GO:0001948
P06239 (UniProtKB)
IPI
GO:0001948
P06239 (UniProtKB)
IPI
GO:0001948
P06239 (UniProtKB)
IPI
GO:0004713
P06239 (UniProtKB)
ISS
GO:0004713
P06239 (UniProtKB)
EXP
GO:0004713
P06239 (UniProtKB)
EXP
GO:0004713
P06239 (UniProtKB)
EXP
GO:0004713
P06239 (UniProtKB)
IDA
GO:0004713
P06239 (UniProtKB)
EXP
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004715
P06239 (UniProtKB)
IBA
GO:0004722
P06239 (UniProtKB)
ISS
GO:0004722
P06239 (UniProtKB)
IDA
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005524
P06239 (UniProtKB)
IEA
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005886
P06239 (UniProtKB)
IDA
GO:0005886
P06239 (UniProtKB)
TAS
GO:0005886
P06239 (UniProtKB)
TAS
GO:0006468
P06239 (UniProtKB)
IDA
GO:0006470
P06239 (UniProtKB)
IEA
GO:0006882
P06239 (UniProtKB)
ISS
GO:0006882
P06239 (UniProtKB)
IEP
GO:0006919
P06239 (UniProtKB)
ISS
GO:0006919
P06239 (UniProtKB)
IDA
GO:0007169
P06239 (UniProtKB)
IBA
GO:0008022
P06239 (UniProtKB)
IPI
GO:0014066
P06239 (UniProtKB)
TAS
GO:0016032
P06239 (UniProtKB)
IEA
GO:0016301
P06239 (UniProtKB)
TAS
GO:0019901
P06239 (UniProtKB)
IPI
GO:0019903
P06239 (UniProtKB)
IPI
GO:0030097
P06239 (UniProtKB)
NAS
GO:0030168
P06239 (UniProtKB)
TAS
GO:0030217
P06239 (UniProtKB)
ISS
GO:0030217
P06239 (UniProtKB)
IMP
GO:0031234
P06239 (UniProtKB)
IBA
GO:0031295
P06239 (UniProtKB)
TAS
GO:0031295
P06239 (UniProtKB)
TAS
GO:0038083
P06239 (UniProtKB)
IBA
GO:0042127
P06239 (UniProtKB)
IBA
GO:0042169
P06239 (UniProtKB)
ISS
GO:0042169
P06239 (UniProtKB)
IPI
GO:0042169
P06239 (UniProtKB)
IPI
GO:0042493
P06239 (UniProtKB)
ISS
GO:0042493
P06239 (UniProtKB)
IDA
GO:0042609
P06239 (UniProtKB)
IPI
GO:0042610
P06239 (UniProtKB)
IPI
GO:0042802
P06239 (UniProtKB)
IPI
GO:0043548
P06239 (UniProtKB)
IPI
GO:0045087
P06239 (UniProtKB)
IBA
GO:0045121
P06239 (UniProtKB)
ISS
GO:0045121
P06239 (UniProtKB)
IDA
GO:0045121
P06239 (UniProtKB)
IDA
GO:0046854
P06239 (UniProtKB)
IEA
GO:0046934
P06239 (UniProtKB)
TAS
GO:0048015
P06239 (UniProtKB)
TAS
GO:0050690
P06239 (UniProtKB)
TAS
GO:0050690
P06239 (UniProtKB)
TAS
GO:0050852
P06239 (UniProtKB)
TAS
GO:0050853
P06239 (UniProtKB)
IBA
GO:0050862
P06239 (UniProtKB)
NAS
GO:0050870
P06239 (UniProtKB)
ISS
GO:0050870
P06239 (UniProtKB)
IDA
GO:0050900
P06239 (UniProtKB)
TAS
GO:0051117
P06239 (UniProtKB)
IPI
GO:0051209
P06239 (UniProtKB)
ISS
GO:0051249
P06239 (UniProtKB)
NAS
GO:0070062
P06239 (UniProtKB)
IDA
GO:0070062
P06239 (UniProtKB)
IDA
GO:0070062
P06239 (UniProtKB)
IDA
GO:2001244
P06239 (UniProtKB)
ISS
GO:2001244
P06239 (UniProtKB)
IMP
GO:0004715
Q573B4 (UniProtKB)
IEA
GO:0005524
Q573B4 (UniProtKB)
IEA
GO:0018108
Q573B4 (UniProtKB)
IEA
GO:0018108
Q573B4 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating LCK:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
IMMUNODEFICIENCY 22 0.24 1 0 ORPHANET_UNIPROT
HIV Infections 0.083724241 7 0 BeFree_GAD_RGD
Allergic Conjunctivitis 0.08 1 0 RGD
Anoxia 0.0054487 2 0 LHGDN
Hepatitis C 0.00272435 1 0 LHGDN
Mammary Neoplasms 0.00272435 1 0 LHGDN
Disease Progression 0.00272435 1 0 LHGDN
Lung diseases 0.00272435 1 0 LHGDN
Tobacco Use Disorder 0.002367032 1 0 GAD
Leukemia, T-Cell 0.001085767 4 0 BeFree

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