RAB17基因详情-基因数据库-基因云馆

RAB17 (RAB17, member RAS oncogene family)

symbol:: RAB17
locus group:: protein-coding gene
location:: 2q37.3
gene_family:: RAB, member RAS oncogene GTPases
alias symbol:: None
alias name:: None
entrez id:: 64284
ensembl gene id:: ENSG00000124839
ucsc gene id:: uc002vwz.3
refseq accession:: NM_022449
hgnc_id:: HGNC:16523
approved reserved:: 2001-09-14

2q37.3

RAB17是RAB基因家族（Ras-related in brain，Ras相关脑蛋白家族）的成员之一，属于小GTP酶超家族。RAB家族主要调控细胞内囊泡运输、膜 trafficking（膜转运）和信号转导等过程。RAB17在多种组织中表达，但尤其在极化上皮细胞（如肾脏和肠道）中发挥重要作用，参与顶端 recycling endosome（循环内体）的运输和蛋白质分选，影响细胞极性建立和维持。其表达产物RAB17蛋白通过GTP/GDP结合状态切换（类似分子开关）调控囊泡与特定膜区室的对接与融合。突变可能导致RAB17功能丧失或异常激活，破坏囊泡运输，进而影响细胞极性相关疾病（如某些癌症或肾脏疾病）。研究发现RAB17过表达可能促进某些肿瘤（如乳腺癌）的转移，因其能增强侵袭相关蛋白的运输；而敲低表达则可能损害上皮屏障功能，导致极性紊乱。该基因与溶酶体储存障碍、纤毛病等也存在潜在关联。RAB家族共性包括：均含有保守的GTP酶结构域，通过结合GTP（激活态）或GDP（失活态）循环发挥作用，并需要GEF（鸟苷酸交换因子）和GAP（GTP酶激活蛋白）调控；多数C端带有异戊二烯化修饰（脂修饰）以保证膜定位。目前中文常将"recycling endosome"直译为循环内体，但更准确的译法应为再循环内体（英文原词）。

中文English

小GTP酶的饶亚科起着膜运输的调节具有重要作用。 RAB17是上皮细胞特异性GTP酶（Lutcke等人，1993 [搜索PubMed 8486736]）。[由OMIM，2009年10月供给]

OMIM数据库中对RAB17基因的介绍 Wikipedia数据库中对RAB17基因的介绍

RAB17基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MAQAHRTPQP RAAPSQPRVF KLVLLGSGSV GKSSLALRYV
41KNDFKSILPT VGCAFFTKVV DVGATSLKLE IWDTAGQEKY
81
HSVCHLYFR GANAALLVYD ITRKDSFLKA QQWLKDLEEE
121LHPGEVLVML VGNKTDLSQE REVTFQEGKE FADSQKLLFM
161E
TSAKLNHQ VSEVFNTVAQ ELLQRSDEEG QALRGDAAVA
201LNKGPARQAK CCAH

结构预测来自 AlphaFold DB（UniProt: Q9H0T7），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

RAB17基因的碱基突变：仅显示部分snp

rs2292870 rs2292871 rs6431548 rs6431549 rs6742869 rs6742960 rs6745883 rs6755617 rs10084167 rs11350972 rs13382953 rs73999157 rs76111307 rs76944243 rs77453530 rs78056409 rs79104302

RAB17基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

TCGGTACGTGAAGAACGAC

59

CAGGAAGGAAGATGAGCCC

59

GTTCAAGCTGGTTCTCCTG

58

TTGAGGAAGGAATCAGCCC

59

GCCTCTGAAATGCTCACTC

58

TCTTTGTTGCACTTTGCAG

57

GAGAAGTCCTGGTGATGCT

59

AACTCCTTCCCTTCCTGGA

59

CACAAAGGTGGTGGATGTG

59

GAGGAAGGAATCCTTCCTGG

59

TGATGACAGGCTCTTCAGC

59

CATTTCTTCCTGGCACCAC

59

CAATACAGTGGCCCAAGAG

58

TCAGAATCCACCTAGAGCTG

58

AGAAGTCCTGGTGATGCTG

59

AAACTCCTTCCCTTCCTGG

59

GCCTCTGAAATGCTCACTC

58

CTTTGTTGCACTTTGCAGTC

58

CACAAAGGTGGTGGATGTG

59

AGGAAGGAATCCTTCCTGG

58

尚未收录相关数据

RAB17基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

RAB17基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005525

C9J0T6 (UniProtKB)

IEA

GO:0005622

C9J0T6 (UniProtKB)

IEA

GO:0007264

C9J0T6 (UniProtKB)

IEA

GO:0005525

F8WAG1 (UniProtKB)

IEA

GO:0005622

F8WAG1 (UniProtKB)

IEA

GO:0007264

F8WAG1 (UniProtKB)

IEA

GO:0005525

H7C1P7 (UniProtKB)

IEA

GO:0005622

H7C1P7 (UniProtKB)

IEA

GO:0007264

H7C1P7 (UniProtKB)

IEA

GO:0002415

Q9H0T7 (UniProtKB)

ISS

GO:0003924

Q9H0T7 (UniProtKB)

IDA

GO:0005515

Q9H0T7 (UniProtKB)

IPI

GO:0005515

Q9H0T7 (UniProtKB)

IPI

GO:0005515

Q9H0T7 (UniProtKB)

IPI

GO:0005515

Q9H0T7 (UniProtKB)

IPI

GO:0005525

Q9H0T7 (UniProtKB)

IEA

GO:0005622

Q9H0T7 (UniProtKB)

IDA

GO:0005769

Q9H0T7 (UniProtKB)

IBA

GO:0005886

Q9H0T7 (UniProtKB)

IBA

GO:0007264

Q9H0T7 (UniProtKB)

IEA

GO:0015031

Q9H0T7 (UniProtKB)

IEA

GO:0016323

Q9H0T7 (UniProtKB)

ISS

GO:0016324

Q9H0T7 (UniProtKB)

ISS

GO:0019003

Q9H0T7 (UniProtKB)

IDA

GO:0030100

Q9H0T7 (UniProtKB)

IBA

GO:0030139

Q9H0T7 (UniProtKB)

IDA

GO:0030425

Q9H0T7 (UniProtKB)

ISS

GO:0032401

Q9H0T7 (UniProtKB)

ISS

GO:0032402

Q9H0T7 (UniProtKB)

ISS

GO:0032456

Q9H0T7 (UniProtKB)

ISS

GO:0032456

Q9H0T7 (UniProtKB)

IBA

GO:0042384

Q9H0T7 (UniProtKB)

IMP

GO:0042470

Q9H0T7 (UniProtKB)

ISS

GO:0043025

Q9H0T7 (UniProtKB)

ISS

GO:0045056

Q9H0T7 (UniProtKB)

ISS

GO:0046847

Q9H0T7 (UniProtKB)

ISS

GO:0050773

Q9H0T7 (UniProtKB)

ISS

GO:0051489

Q9H0T7 (UniProtKB)

ISS

GO:0051963

Q9H0T7 (UniProtKB)

ISS

GO:0055037

Q9H0T7 (UniProtKB)

ISS

GO:0055038

Q9H0T7 (UniProtKB)

ISS

GO:0055038

Q9H0T7 (UniProtKB)

IBA

GO:0070062

Q9H0T7 (UniProtKB)

IDA

可能调控 RAB17基因的相关microRNA：

String

BioGrid

IntAct

mentha

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关联基因	作用方式	资源库来源/分值

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Tobacco Use Disorder	0.002367032	1	0	GAD
Neoplasm Metastasis	0.000271442	1	0	BeFree
Liver carcinoma	0.000271442	1	0	BeFree

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Zhu W, Wang J, Zhou Y, Song S, Li C, Xue Q, Zhang H Transl Androl Urol IF: 1.9 2026-07-31

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Olaoye OJ, Farrow SL, Cooper AA, Nyaga DM, O'Sullivan JM BMC Med Genomics IF: 2.848 2026-04-30

Pangenomes reveal extensive structural variation in a suboscine passerine bird, the Pearly-vented Tody-Tyrant (Hemitriccus margaritaceiventer).

Lopez KA, de Carvalho CF, de Lima HS, Naka LN, Amaral FRD, Bravo GA, Edwards SV Genetics IF: 0.000 2026-07-06

RAB17 downregulation elicits antitumor impacts in prostate cancer by triggering ferroptotic cell death through the regulation of TfR1-mediated iron overload.

Ruan D, Su W, Zhang Y, Ma X Toxicol Appl Pharmacol IF: 3.6 2026-08-27

Transcriptomic and differential gene analysis investigating the differences in biological behaviour between subtypes of feline alimentary lymphoma.

McGilp D, Roccabianca P, Hulse L, Allavena R, Palmieri C Front Vet Sci None

Assay of Rab17 and its guanine nucleotide exchange factor Rabex-5 in the dendrites of hippocampal neurons.

Mori Yasunori, Fukuda Mitsunori Methods Mol Biol 2016-03-08

Down-regulation of Rab17 promotes tumourigenic properties of hepatocellular carcinoma cells via Erk pathway.

Qi Jingsong, Zhao Peng, Li Fenbao, Guo Yingchang, Cui Hongkai, Liu Aiguang, Mao Huajie, Zhao Yongli, Zhang Xizhong Int J Clin Exp Pathol IF: 1.3 2016-04-18

Biological Control Activities of Rice-Associated Bacillus sp. Strains against Sheath Blight and Bacterial Panicle Blight of Rice.

Shrestha Bishnu K, Karki Hari Sharan, Groth Donald E, Jungkhun Nootjarin, Ham Jong Hyun PLoS One IF: 2.6 2016-07-26

The GTP-bound and Sumoylated Form of the rab17 Small Molecular Weight GTPase Selectively Binds Syntaxin 2 in Polarized Hepatic WIF-B Cells.

Striz Anneliese C, Tuma Pamela L J Biol Chem IF: 4.1 2016-11-10

Rab17 inhibits the tumourigenic properties of hepatocellular carcinomas via the Erk pathway.

Wang Kejia, Mao Zhujun, Liu Li, Zhang Ronghua, Liang Qing, Xiong Yaokang, Yuan Wenjun, Wei Li Tumour Biol IF: 3.650 2015-11-16

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RAB17 (RAB17, member RAS oncogene family)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

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