RAP1A基因详情-基因数据库-基因云馆

RAP1A (RAP1A, member of RAS oncogene family)

symbol:: RAP1A
locus group:: protein-coding gene
location:: 1p13.2
gene_family:: RAS type family GTPases
alias symbol:: KREV-1|SMGP21
alias name:: None
entrez id:: 5906
ensembl gene id:: ENSG00000116473
ucsc gene id:: uc001ebi.4
refseq accession:: NM_002884
hgnc_id:: HGNC:9855
approved reserved:: 1989-06-30

1p13.2

RAP1A（Ras-related protein Rap-1A）属于Ras超家族中的RAP亚家族，该家族还包括RAP1B、RAP2A、RAP2B等成员。Ras超家族基因的共同特点是编码小GTP酶，这些蛋白通过结合GTP（激活态）或GDP（失活态）来调节细胞信号传导，参与细胞增殖、分化、黏附及迁移等过程。RAP1A在多种组织中表达，尤其在血小板、免疫细胞和神经元中丰度较高。其功能主要依赖于GTP/GDP循环，通过激活下游效应蛋白（如MAPK、PI3K通路）调控细胞黏附、细胞连接和细胞极性。RAP1A在整合素介导的细胞-基质黏附中起关键作用，影响免疫细胞的迁移和炎症反应。此外，它还与血管生成和突触可塑性相关。突变或表达异常可能导致功能紊乱，例如RAP1A功能丧失性突变与某些免疫缺陷和血小板功能障碍有关，而过表达则可能促进肿瘤细胞的侵袭和转移，因其增强整合素信号和细胞运动性。在癌症中，RAP1A的异常激活与乳腺癌、结肠癌等进展相关。RAP1A还通过调控VE-钙黏蛋白影响血管内皮屏障功能，其表达降低可能导致血管通透性增加。在神经系统，RAP1A参与神经元突触的形成和维持，表达异常可能与神经退行性疾病有关。RAP家族成员的共性包括高度保守的GTP结合域、相似的效应蛋白识别机制，以及参与细胞骨架重组和膜运输调控。RAP1A与RAP1B功能部分冗余，但组织分布和调控途径存在差异。例如，RAP1B在血小板活化中更关键，而RAP1A对神经元功能影响更显著。研究还发现，RAP1A可通过交叉对话抑制Ras蛋白的活性，从而平衡生长信号。其表达受转录因子（如SP1）和表观遗传修饰调控，miR-30家族等非编码RNA也可靶向抑制RAP1A翻译。总之，RAP1A作为细胞信号网络的关键节点，其功能精细调控对维持组织稳态至关重要，而失调可能导致多种病理状态。

中文English

该基因编码的Ras家族小GTP酶中的一员。该编码的蛋白经受??构象状态和活性的改变，这取决于它是否绑定GTP或国内生产总值。这种蛋白是由几种类型的鸟嘌呤核苷酸交换因子（环基金）激活，并通过两组GTP酶激活蛋白（GAP）的失活。因此所编码的蛋白质的活化状态是受环基金和GAP的细胞内水平的平衡。所编码的蛋白质调节的信号影响细胞增殖和粘附，并可能在肿瘤恶性作用途径。这个基因的假基因已在染色体14，并在多个转录变异体17选择性剪接的结果来定义。 [由RefSeq的，2014年5月提供]

OMIM数据库中对RAP1A基因的介绍 Wikipedia数据库中对RAP1A基因的介绍

RAP1A基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY
41RKQVEVDCQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL
81
VYSITAQST FNDLQDLREQ ILRVKDTEDV PMILVGNKCD
121LEDERVVGKE QGQNLARQWC NCAFLESSAK SKINVNEIFY
161D
LVRQINRK TPVEKKKPKK KSCLLL

结构预测来自 AlphaFold DB（UniProt: P62834），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

RAP1A基因的碱基突变：仅显示部分snp

rs6573 rs13059 rs472159 rs473068 rs473401 rs474077 rs474722 rs474860 rs475502 rs475645 rs476515 rs480578 rs484495 rs485540 rs486895 rs486982 rs490011

RAP1A基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GCTCAGTCCACGTTTAACG

59

AATCATTGGAACATCTTCCGTG

59

GGGAAGTCTGCTCTGACAG

59

TCTGTAGGAATCTTCTATCGTTGG

59

TGGGATAACTGGATCAGAGG

58

ATACTGACGATTCAATGCCA

57

GCTCAGTCCACGTTTAACG

59

AATCATTGGAACATCTTCCGTG

59

GCTCAGTCCACGTTTAACG

59

AATCATTGGAACATCTTCCGTG

59

GGGAAGTCTGCTCTGACAG

60

TCTGTAGGAATCTTCTATCGTTGG

60

AGATCACATCATGCGTGAG

57

ACAAACTGAACTGTCAGAGC

58

GGGAAGTCTGCTCTGACAG

60

TCTGTAGGAATCTTCTATCGTTGG

60

GGGAAGTCTGCTCTGACAG

60

TCTGTAGGAATCTTCTATCGTTGG

60

GGATAACTGGATCAGAGGGT

58

ATACTGACGATTCAATGCCA

57

转录因子

影响基因

影响类型

参考文献链接（PubMed）

TWIST1

RAP1A

Repression

19051271

TWIST2

RAP1A

Repression

19051271

RAP1A基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

RAP1A基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005525

A0A075B6Q0 (UniProtKB)

IEA

GO:0005622

A0A075B6Q0 (UniProtKB)

IEA

GO:0007264

A0A075B6Q0 (UniProtKB)

IEA

GO:0016020

A0A075B6Q0 (UniProtKB)

IEA

GO:0000186

P62834 (UniProtKB)

TAS

GO:0003924

P62834 (UniProtKB)

IEA

GO:0005515

P62834 (UniProtKB)

IPI

GO:0005515

P62834 (UniProtKB)

IPI

GO:0005515

P62834 (UniProtKB)

IPI

GO:0005515

P62834 (UniProtKB)

IPI

GO:0005515

P62834 (UniProtKB)

IPI

GO:0005515

P62834 (UniProtKB)

IPI

GO:0005515

P62834 (UniProtKB)

IPI

GO:0005515

P62834 (UniProtKB)

IPI

GO:0005515

P62834 (UniProtKB)

IPI

GO:0005525

P62834 (UniProtKB)

IEA

GO:0005737

P62834 (UniProtKB)

IDA

GO:0005737

P62834 (UniProtKB)

IDA

GO:0005769

P62834 (UniProtKB)

ISS

GO:0005770

P62834 (UniProtKB)

ISS

GO:0005829

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0005886

P62834 (UniProtKB)

TAS

GO:0007165

P62834 (UniProtKB)

TAS

GO:0008565

P62834 (UniProtKB)

IDA

GO:0010976

P62834 (UniProtKB)

ISS

GO:0015031

P62834 (UniProtKB)

IDA

GO:0017016

P62834 (UniProtKB)

IEA

GO:0017034

P62834 (UniProtKB)

ISS

GO:0030054

P62834 (UniProtKB)

ISS

GO:0032045

P62834 (UniProtKB)

IEA

GO:0032403

P62834 (UniProtKB)

IDA

GO:0032403

P62834 (UniProtKB)

IDA

GO:0032486

P62834 (UniProtKB)

IMP

GO:0032966

P62834 (UniProtKB)

IEA

GO:0035690

P62834 (UniProtKB)

IEA

GO:0038180

P62834 (UniProtKB)

ISS

GO:0043005

P62834 (UniProtKB)

IEA

GO:0043209

P62834 (UniProtKB)

IEA

GO:0043547

P62834 (UniProtKB)

ISS

GO:0045860

P62834 (UniProtKB)

ISS

GO:0046326

P62834 (UniProtKB)

IEA

GO:0048471

P62834 (UniProtKB)

IDA

GO:0050766

P62834 (UniProtKB)

IEA

GO:0050796

P62834 (UniProtKB)

TAS

GO:0061028

P62834 (UniProtKB)

IMP

GO:0070062

P62834 (UniProtKB)

IDA

GO:0070062

P62834 (UniProtKB)

IDA

GO:0070374

P62834 (UniProtKB)

ISS

GO:0071320

P62834 (UniProtKB)

IDA

GO:0071333

P62834 (UniProtKB)

IEA

GO:0097327

P62834 (UniProtKB)

IEA

GO:0097421

P62834 (UniProtKB)

IEA

GO:1901888

P62834 (UniProtKB)

IMP

GO:1990090

P62834 (UniProtKB)

ISS

GO:2000301

P62834 (UniProtKB)

IEA

GO:2001214

P62834 (UniProtKB)

ISS

GO:0030033

P62834 (UniProtKB)

IMP

可能调控 RAP1A基因的相关microRNA：

hsa-miR-196a hsa-let-7e hsa-miR-337-3p

String

BioGrid

IntAct

mentha

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4015 Rap1 signaling pathway [PATH:hsa04015]
4010 MAPK signaling pathway [PATH:hsa04010]
4024 cAMP signaling pathway [PATH:hsa04024]
4510 Focal adhesion [PATH:hsa04510]
4611 Platelet activation [PATH:hsa04611]
4670 Leukocyte transendothelial migration [PATH:hsa04670]
4062 Chemokine signaling pathway [PATH:hsa04062]
4972 Pancreatic secretion [PATH:hsa04972]
4720 Long-term potentiation [PATH:hsa04720]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
5211 Renal cell carcinoma [PATH:hsa05211]

名称
Adaptive Immune System
ARMS-mediated activation
Frs2-mediated activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
GRB2:SOS provides linkage to MAPK signaling for Integrins
Hemostasis
Immune System
Integration of energy metabolism
Integrin alphaIIb beta3 signaling
NGF signalling via TRKA from the plasma membrane
p130Cas linkage to MAPK signaling for integrins
Platelet activation, signaling and aggregation
Platelet Aggregation (Plug Formation)
Prolonged ERK activation events
Rap1 signalling
Regulation of insulin secretion
Signalling by NGF
Signalling to ERKs

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Osteoporosis	0.122638474	1	1	BeFree_GAD_GWASCAT
Myocardial Reperfusion Injury	0.08	1	0	RGD
Hyperoxaluria	0.08	1	0	RGD
Squamous cell carcinoma	0.003538676	3	0	BeFree_LHGDN
Leukocyte-Adhesion Deficiency Syndrome	0.002995792	1	0	BeFree_LHGDN
MYELODYSPLASTIC SYNDROME	0.00272435	1	0	LHGDN
Thyroid Neoplasm	0.002638474	2	0	BeFree_GAD
Systemic arterial pressure	0.002367032	1	1	GAD
Carcinoma, Papillary	0.002367032	1	0	GAD
Blood pressure finding	0.002367032	1	1	GAD

A novel epigenetic regulation of JAM-A by EZH2-DNMT3A cascade contributes to T cell adhesion via the activation of Rap1a in lupus patients.

Ding L, Gu H, Zhong Y, Chen H, Lin W, Lei Q, Yang L, Yu H, Song H, Zhang X, Yu M, Chang X, Lin J, Cui Q J Transl Autoimmun IF: 3.8 2026-06-00

Nintedanib Eye Drops Inhibit Alkali Burn-Induced Corneal Neovascularization Via RAP1/MEK/ERK Signaling Pathway.

Li J, Zhang G, Li J, Liu R, Zhu L, Li J, Li Z Invest Ophthalmol Vis Sci IF: 5.5 2026-03-02

RNA decay rate as a control point for long non-coding RNA function: a BRIC-based causal analysis of NEAT1.

Tani H Gene IF: 2.7 2026-08-21

ARHGAP20 organizes spatial Rap1-RhoA signaling coordination controlling adhesion dynamics during migration.

Pagano S, Sanchez C, Cox-Cammer N, Bhalla RM, Ravishankar R, Segura-Villalobos D, Muesch A, Aguirre-Ghiso JA, Danuser G, Hodgson L bioRxiv 2026-07-20

Research advances in rumen development and regulatory mechanisms in young ruminants.

Yu G, Wu D PeerJ IF: 2.9 None

Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass.

Simanshu DK, McCormick F Biochem J IF: 3.9 2026-05-06

High PGE2 Levels Inhibit the Migration of Dendritic Cells by Modulating the PKA-CREB Axis Instead of Epac1-Rap1.

Diao G, Huang J, Tian M, Li R, Guo J, Han J Scientifica (Cairo) IF: 3.6 None

Protein-based pan-RAS inhibitor induces tumor regression in female mice via IFNγ and CD8+ T cell-dependent tumor necrosis.

Nomura TK, Heishima K, Mukai H, Arai K, Elhelaly AE, Fuchigami H, Warashina S, Tahara T, Hyodo F, Matsuo M, Yasunaga M, Aoki K, Honda R Nat Commun IF: 12.124 2026-05-16

Albiflorin alleviates osteoporosis through suppression of osteoclast mitophagy via the Rap1a/ERK signaling pathway.

Tang C, Yu J, Sheng D, Gu Y, Xia D, Lan K, Li Y, Yang Y, Feng C, Gong Y, Xiao L, Wang Z Phytomedicine IF: 11.3 2026-04-00

ESRP1 drives epithelial-mesenchymal transition by activating EPAC-RAP1A signaling axis.

Qi R, Wang J, Cheng G, Zhao T, Hu Z, Yu J, Jia Y, Chen J Front Med (Lausanne) None

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RAP1A (RAP1A, member of RAS oncogene family)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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